Download Curriculum Vitae

專題演講
主
題 ： Osteoimmunology - An Update
主 講 人 ： Prof. Hiroshi Takayanagi
主持人：
許秉寧教授
國立台灣大學醫學院免疫學研究所所長
時
間 ： 98 年 12 月 7 日 (星期一) 10:00~11:00
地
國立台灣大學醫學院 508 講堂
點 ： 台北市中正區仁愛路一段 1 號
中華民國風濕病醫學會
主辦單位： 國立台灣大學醫學院免疫學研究所
國立台灣大學醫學院附設醫院醫學研究所
教育積分
台灣內科醫學會
中華民國免疫學會
Topic : Osteoimmunology - An Update
Speaker: Hiroshi Takayanagi
Abstract
Osteoclasts are unique, multinucleated giant cells that decalcify and degrade the bone
matrix. They originate from hematopoietic cells and their differentiation is dependent on a
tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor-kappaB
(NF-kappaB) ligand (RANKL), as well as macrophage-colony stimulating factor (M-CSF).
Recent
studies
have
unveiled
the
precise
molecular
mechanism
underlying
osteoclastogenesis. In particular, the discovery of nuclear factor of activated T cells c1
(NFATc1), the master regulator of osteoclastogenesis, has proven to be a breakthrough in
this field. NFATc1 is activated by Ca2+ signaling induced by the activation of the
immunoglobulin-like receptor signaling associated with immunoreceptor tyrosine-based
activation motif (ITAM)-harboring adapters. The long-lasting Ca2+ oscillation, which is
evident during osteoclastogenesis, may ensure the robust induction of NFATc1 through an
autoamplification mechanism. Thus, intracellular Ca2+ is a critical attribute of
osteoclastogenic signaling. In addition, osteoclasts are exposed to a very high extracellular
Ca2+ concentration ([Ca2+]o) in the bone microenvironment and respond to the change in
[Ca2+]o by increasing the intracellular Ca2+, which regulates diverse cellular functions.
Investigation of the molecular mechanisms underlying the regulation of intracellular Ca2+
dynamics may open up new directions for therapeutic strategies in bone disease.
Hiroshi Takayanagi, MD, Ph.D
Dep of Cell Signaling, Tokyo Medical & Dental University
By combining experiences as an orthopaedic surgeon and an immunologist, I studied
in the laboratory of Professor Tada Taniguchi the mechanism of bone destruction in
rheumatoid arthritis, which focused on the regulation of osteoclasts by T cells. I have
been Professor of Tokyo Medical and Dental University since 2003, and pursue this
interdisciplinary field, osteoimmunology, which covers various researches on shared
mechanisms and interactions between immune and bone systems.
【Major Publications】
Takayanagi H et al. Nature 408, 600-605 (2000)
Takayanagi H et al. Nature 416,
744-749 (2002)
Takayanagi H et al. Dev Cell 3, 889-901 (2002)
Koga T et al. Nature 428, 758-763
(2004)
Takayanagi H. Nat Rev Immunol 7, 292-304 (2007)
Asagiri M et al. Science 319, 624-627 (2008)
Shinohara M et al. Cell 132, 794-806
(2008)
【Academic and professional awards】
Amersham Biosciences and Science Prize for Young Scientists (2002)
Novartis Japan Rheumatology Prize (2002), Japan College of Rheumatology Award
(2004)
Fuller Albright Award, ASBMR (2004)
Japan Society for the Promotion of Science Prize (2005)
Japan Academy Medal (2005)
International Research Prize, Austrian Society for Bone and Mineral Research and
Ludwig Boltzmann Institute of Osteology (2006)
Academic Award of the Mochida Memorial Foundation (2008)
Inoue Prize for Science (2009)
JSBMR Distinguished Scientist Award (2009)
【Social activity】
Vice President of Asia Pacific League of Associations for Rheumatology
(2004.11-2008.9),
Organizing Committee of International Conference on Osteoimmunology (2005.3current), Member of American Society for Clinical Investigation (2008.4- current)
【Editorial board / Associate Editor】
Bone, Endocrinology, Int J Mol Med, JBMM, JBMR, J Orthop Sci, Mod Rheumatol
【Ad Hoc Reviewing】
Nat Med, Nat Immunol, Nat Cell Biol, Genes Dev, Dev Cell, J Exp Med, EMBO J, Proc Natl
Acad Sci U S A, Arthritis Rheum, Eur J Immunol, Biochem Biophys Res Commun, J Cell
Biol, Osteoarthritis Cartilage, Mod Rheumatol
Curriculum Vitae
Hiroshi Takayanagi, MD, Ph.D
Professor, Department of Cell Signaling, Graduate School,
Tokyo Medical and Dental University
1-5-45, Yushima Bunkyo-ku, Tokyo 113-8549 JAPAN
Tel:+81-3-5803-5471 Fax:+81-3-5803-0192
Email:
[email protected]
Birthday: Oct 7, 1965.
1965
Born in Tokyo
1990
Graduated from the Faculty of Medicine, the University of Tokyo,
MD
1990-91
Dep of Orthopaedic surgery, the University of Tokyo Hospital
1991-92
Dep of Orthopaedic surgery, Toshiba hospital
1992-1996
Dep of Orthopaedic surgery, Tokyo Metropolitan Hospital
1996-97
Dep of Orthopaedic surgery, the University of Tokyo Hospital
1997-2001
Doctoral course, Dep of Orthopaedic surgery (Prof. Kozo
Nakamura, Dr. Sakae Tanaka) and Immunology, Graduate School
of Medicine, the University of Tokyo (Prof. Taniguchi Tadatsugu)
2001.3.28
Ph.D, the University of Tokyo
2001.6.1
Associate, Department of Immunology, Graduate School of
Medicine, the University of Tokyo (Prof. Taniguchi Tadatsugu)
2001.11.1
Principal investigator in the PRESTO program, Japan Science and
Technology Corporation (JST)
2003.10.1
Professor, Department of Cellular Physiological Chemistry,
Graduate School, Tokyo Medical and Dental University
2005.4.1
Professor, Department of Cell Signaling,
Graduate School, Tokyo Medical and Dental University
Academic and professional awards
1997
Young Investigator's Award, 19th Annual meeting of American society of
bone and mineral research, 1997.9.14
1997
Best abstract award, 12th Japanese Society of Orthopaedic surgery, 1998
Travel award, Second joint meeting of the American Society for Bone
and Mineral Research and the International Bone and Mineral Society,
2001
Award of Physician’s association, Univ of Tokyo 2001.4.18
2002
18th Inoue research award 2002.2.4
Young Investigator Award, International Cytokine Society 2002.10.6
Amersham Biosciences and Science Prize for Young Scientists 2002.11.20
2004
Novartis Japan Rheumatology Prize 2004.4.14
Japan College of Rheumatology Award, 2004.4.15
Fuller Albright Award, 26th Annual Meeting of The American Society for
Bone and Mineral Research 2004.10.2
2005
Japan Society for the Promotion of Science Prize 2005.3.22
Japan Academy Medal, 2005.3.22
The Young Scientists’ Prize, The Commendation for Science and Technology
by the Minister of Education, Culture, Sports, Science and Technology
2005.4.20
NISTEP AWARD 2005
National Institute of Science and Technology
Policy, Ministry of Education, Culture, Sports, Science and Technology
2005.12.27
2006
2006 International Research Prize, Austrian Society for Bone and
Mineral Research and Ludwig Boltzmann Institute of
Osteology 2006.11.17
2008
Academic Award of the Mochida Memorial Foundation 2008.10.17
2009
Inoue Prize for Science 2009.2.4
JSBMR Distinguished Scientist Award 2009.7.24
Social activity
2004.11-2008.9
Vice President, Asia Pacific League of Associations for
Rheumatology
2005.3- current.
Osteoimmunology:
Organizing
Committee,
International
Conference
on
Interactions of the Immune and Skeletal Systems
2006.8- current.
Associate Member, Science Council of Japan
2006.9- 2007.12
Ancillary Program Committee, American Society for Bone and
Mineral Research (ASBMR)
2008.1-current
Associate Editor, Journal of Bone and Mineral Research
2008.4- current
American Society for Clinical Investigation Member
Associate Editor JBMR
Transmitting Editor
Mod Rheumatol
Editorial board
J Orthop Sci, Bone, Int J Mol Med, Endocrinology,
JBMM
Ad Hoc Reviewing
Nat Med, Nat Immunol, Nat Cell Biol, Genes Dev, Dev
Cell, J Exp Med, EMBO J, Proc Natl Acad Sci U S A,
Arthritis Rheum, Eur J Immunol, Biochem Biophys Res
Commun, J Cell Biol, Osteoarthritis Cartilage, Mod
Rheumatol
Publications
1. Original articles
Negishi-Koga, T. and Takayanagi, H. Mysteries in Ca2+ Signaling During Osteoclast
Differentiation. IBMS BoneKEy. 301- 306 (2009) Epub.
Kayama, H., Koga, R., Atarashi, K., Okuyama, M., Kimura, T., Mak, T. W., Uematsu,
S., Akira, S., Takayanagi, H., Honda, K., Yamamoro, M., and Takeda, K. NFATc1
Mediates Toll-Like Receptor-Independent Innate Immune Responses during
Trypanosoma cruzi Indection. PLoS Pathogens. Vol. 5, Issue 7, e1000514 (2009)
Kadono, Y., Tanaka, S., Nishino, J., Nishimura, K., Nakamura, I., Miyazaki, T.,
Takayanagi, H. and Nakamura, K. Rheumatoid arthritis associated with osteopetrosis:
A case report. Mod Rheumatol. (2009) In press.
Nakashima, T. and Takayanagi, H. Osteoimmunology: crosstalk between the immune
and bone systems. J Clin Immunol. (2009) In press.
Takayanagi, H. Cytokine and Growth Factor Regulation of Osteoclastogenesis. The
Skeletal System. 263-270 (2009)
Nakashima, T. and Takayanagi, H. Osteoclasts and the immune systems. J Bone
Miner Metab. (2009) In press.
Mori, Y., Tsuji, S., Inui, M., Sakamoto, Y., Endo, S., Ito, Y., Fujimura, S., Koga, T.,
Nakamura, A., Takayanagi, H., Itoi, E. and Takai, T. Inhibitory immunoglobulin-like
receptors LILRB and PIR-B negatively regulate osteoclast development. J Immunol.
181, 4742-4751 (2008)
Akiyama, T., Shimo, Yu., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y.,
Kitazawa, J., Takayanagi, H., Penninger, J.M., Matsumoto, M., Nitta, T., Takahama, Y.
and Inoue, J. The tumor necrosis factor family receptors RANK and CD40
cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity. 29, 423-437 (2008)
Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto,
M., Matsuo, K., Penninger, J. M., Takayanagi, H., Yokota, Y., Yamada, H., Yoshikai,
Y., Inoue, J., Akiyama, T. and Takahama, Y. RANKL produced by positively selected
thymocytes fosters medullary thymic epithelial cells that express autoimmune
regulator Immunity. 29, 438-450 (2008)
Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T.,
Kodama, T., Morio, T., Geha, R. S., Kitamura, D., Kurosaki, T., Ellmeier, W. and
Takayanagi, H. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by
linking RANK and ITAM signals. Cell. 132, 794-806 (2008)
Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa,
K., Latz, E., Golenbock, D.T., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono,
K., Kato, S., Saftig, P. and Takayanagi, H. Cathepsin K-dependent toll-like receptor 9
signaling revealed in experimental arthritis.. Science. 319, 624-627 (2008)
Nakashima, T. and Takayanagi, H. The dynamic interplay between osteoclasts and the
immune system. Archiv Biochem Biophys. (Highlight Issue: Bone Remodeling)
473(2), 166-171 (2008)---Review
Nakamura, T., Imai, Y., Matsumoto T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y.,
Azuma, Y., Krust, A., Yamamoto, Y., Nishina, H., Takeda, S., Takayanagi, H., Metzger,
D., Kanno, J., Takaoka, K., Martin, T. J., Chambon, P. and Kato, S. Estrogen prevents
bone loss via estrogen receptor a and induction of Fas ligand in osteoclasts. Cell. 130,
811-823 (2007)
Ochi, S., Shinohara, M., Sato, K., Gober H.J., Koga, T., Kodama, T., Takai T.,
Miyasaka N. and Takayanagi H. Pathological role of osteoclast costimulation in
arthritis-induced bone loss. Proc Natl Acad Sci USA. 104, 11394-11399 (2007)
Suematsu, A., Tajiri, Y., Nakashima, T., Taka, J., Ochi, S., Oda, H., Nakamura, K.,
Tanaka S. and Takayanagi H. Scientific basis for the efficacy of combined use of
antirheumatic drugs against bone destruction in rheumatoid arthritis. Mod Rheumatol.
17, 17-23 (2007)
Takayanagi, H. The role of NFAT in osteoclast formation. Ann NY Acad Sci.
1116:227-237 (2007)---Review
Takayanagi, H. Novel signaling pathways and therapeutic targets in osteoclasts.
Adv
Exp Med Biol. 602, 93-96 (2007) ---Review
Takayanagi, H. Interaction between the immune system and bone metabolism: an
emerging field of osteoimmunology. Proc Jpn Acad. SerB 83, 136-143
(2007)---Review
Shinohara, M. and Takayanagi, H. Novel osteoclast signaling mechanisms. Curr
Osteoporos Rep. 5, 67-72 (2007)---Review
Takayanagi, H. Osteoimmunology : shared mechanisms and crosstalk between the
immune and bone systems. Nat Rev Immunol. 7, 292-304 (2007)---Review
Asagiri, M. and Takayanagi, H. The molecular understanding of osteoclast differentiation.
Bone. 40, 251-264 (2007)---Review
Negishi, H., Fujita, Y., Yanai, H., Sakaguchi, S., Ouyang, X., Shinohara, M.,
Takayanagi, H., Ohba, Y., Taniguchi, T. and Honda, K. Evidence for licensing of
IFN-g-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like
receptor-dependent gene induction program. Proc Natl Acad Sci USA. 103,
15136-15141 (2006)
Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y.,
Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., Kodama, T., Chatila, T. A., Bito, H.
and Takayanagi, H. Regulation of osteoclast differentiation and function by the
CaMK-CREB pathway. Nat Med. 12,1410-1416 (2006)
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y.,
Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., Cua, D. J. and Takayanagi, H.
Th17
functions as an osteoclastogenic helper T cell subset that links T cell activation and
bone destruction. J Exp Med. 203, 2673-2682 (2006)
Takayanagi, H. Amazing multifunctionality of calcineurin and NFAT signaling in bone
homestasis. BoneKEy-osteovision. 3, 28-31 (2006)---Review
http://www.bonekey-ibms.org/cgi/content/full/ibmske;3/9/28
Commentary on: Winslow MM, et al.
Calcineurin/NFAT signaling in osteoblasts
regulates bone mass. Dev Cell. 10, 771-82 (2006)
Sato, K. and Takayanagi, H. Osteoclasts, rheumatoid arthritis and osteoimmunology.
Curr Opin Rheumatol. 18, 419-426 (2006)---Review
Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner,
E. F., Mak, T. W., Serfling, E. and Takayanagi, H. Autoamplification of NFATc1
expression determines its essential role in bone homeostasis. J Exp Med.
202,1261-1269 (2005)
Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima K. and
Takayanagi, H. NFAT and Osterix cooperatively regulate bone formation. Nat Med.
11, 880-885 (2005)
Kim, Y., Sato, K., Asagiri, M., Morita, I., Soma, K. and Takayanagi, H. Contribution
of nuclear factor of activated T cells c1 to the transcriptional control of
immunoreceptor osteoclast-associated receptor but not triggering receptor expressed
by myeloid cells-2 during osteoclastogenesis.
J Biol Chem. 280, 32905-32913
(2005)
Lee, F.Y., Kim, D.W., Karmin, J.A., Hong, D., Chang, S.S., Fujisawa, M., Takayanagi,
H., Bigliani, L.U., Blaine, T.A. and Lee, H.J. μ-calpain regulates receptor activator
of NF-kB (RANKL)-supported osteoclastogenesis via NF-kB activation in RAW 264.7
cells. J Biol Chem. 280, 29929-29936 (2005)
Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S. and Inoue, J.
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during
osteoclastogenesis. EMBO. 24,790-799 (2005)
Takatsuna, H., Asagiri, M., Kubota, T., Oka, K., Osada, T., Sugiyama, C., Saito, H.,
Aoki, K., Ohya, K., Takayanagi, H. and Umezawa K.
Inhibition of RANKL-induced
osteoclastogenesis by (-)-DHMEQ, a novel NF-kB inhibitor, through downregulation
of NFATc1. J Bone Miner Res. 20, 653-662 (2005)
Takayanagi, H., Sato, K., Takaoka, A. and Taniguchi, T.
Interplay between interferon
and other cytokine systems in bone metabolism. Immunol Rev. 208, 181-193
(2005)---Review
Takayanagi, H. All Interferons are Not Equal: Specific Mechanisms of Interfering with
Osteoclastogenesis.
BoneKEy-osteovision. 2, 24-28 (2005)
http://www.bonekey-ibms.org/cgi/content/full/ibmske;2/11/24
Commentary on: Coelho LF, et al. Interferon–α and –β differentially regulate
osteoclastogenesis: Role of differential induction of chemokine CXCL11 expression.
Proc Natl Acad Sci USA. 102, 11917-11922 (2005)---Review
Takayanagi, H. Osteoimmunological insight into bone damage in rheumatoid arthritis.
Mod Rheumatol. 15, 225-231 (2005)---Review
Takayanagi, H. Inflammatory bone destruction and osteoimmunology. J Periodont
Res 40, 287-293 (2005)---Review
Takayanagi, H. Mechanistic insight into osteoclast differentiation in osteoimmunology.
J Mol Med. 83, 170-179 (2005)---Review
Takayanagi, H., Kim, S., Koga, T. and Taniguchi, T. Stat1-mediated cytoplasmic
attenuation in osteoimmunology. J Cell Biochem. 94, 232-240 (2005)---Review
Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H., Tsujimoto, M., Katayama, S.,
Hisatake, K. and Nogi, Y. Essential role of p38 mitogen-activated protein kinase in
cathepsin K gene expression during osteoclastogenesis through association of NFATc1
and PU.1. J Biol Chem. 279,45969-79 (2004)
Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi,
H., Matozaki, T., Kodama, T., Taniguchi, T., Takayanagi, H.* and Takai, T.*
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone
homeostasis. Nature. 428,758-763 (2004)
*Corresponding authors
Urushibara, M.*, Takayanagi H.*, Koga, T., Kim, S., Isobe, M., Morishita, Y.,
Nakagawa, T., Löeffler, M., Kodama, T., Kurosawa, H. and Taniguchi, T. The
antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor
activator of NF-kB ligand-stimulated induction of nuclear factor of activated T cells c1.
Arthritis Rheum. 50, 794-804 (2004)
*Equal contributors
Kim, S., Koga, T., Isobe, M., Kern, B. E., Yokochi, T., Chin, Y.E., Karsenty, G.,
Taniguchi, T. and Takayanagi, H. Stat1 functions as a cytoplasmic attenuator of Runx2
in the transcriptional program of osteoblast differentiation.
Genes Dev. 17, 1979-91
(2003)
Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A.,
Isobe, M., Yokochi, T., Inoue, J, Wagner, E. F., Mak, T. W., Kodama, T. and Taniguchi,
T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate
RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 3, 889–901
(2002)
Takayanagi, H., Kim, S., Matsuo, K., Suzuki, H., Suzuki, T., Sato, K., Yokochi, T.,
Oda, H., Nakamura, K., Ida, N., Wagner, E. F. and Taniguchi, T. RANKL maintains
bone homeostasis through c-Fos-dependent induction of IFN-b. Nature. 416, 744-49
(2002)
Nakamura, I., Kadono, Y., Takayanagi, H., Jimi, E., Miyazaki, T., Oda, H., Nakamura,
K., Tanaka, S., Rodan, G. A. and Duong le, T. IL-1 regulates cytoskeletal organization
in osteoclasts via TNF receptor-associated factor 6/c-Src complex. J Immunol. 168,
5103-9 (2002)
Yamamoto, A., Miyazaki, T., Kadono, Y., Takayanagi, H., Miura, T., Nishina, H.,
Katada, T., Wakabayashi, K., Oda, H., Nakamura, K. and Tanaka, S. Possible
involvement of IkB kinase 2 and MKK7 in osteoclastogenesis induced by receptor
activator of nuclear factor kB ligand. J Bone Miner Res. 17, 612-21 (2002)
Ogasawara, K., Hida, S., Weng, Y., Saiura, A., Sato, K., Takayanagi, H., Sakaguchi, S.,
Yokochi, T., Kodama, T., Naitoh, M., De Martino, J. A. and Taniguchi, T. Requirement
of the IFN-a b-induced CXCR3 chemokine signalling for CD8+ T cell activation.
Genes Cells. 7, 309-320 (2002)
Takayanagi, H., Kim, S. and Taniguchi, T. Signaling crosstalk between RANKL and
interferons in osteoclast differentiation. Arthritis Res. 4, S227-232 (2002)---Review
Takayanagi, H. How does the immune system break and protect bone?
Science.
(on line version, 2002)---Review
(http://www.sciencemag.org/feature/data/pharmacia/2002/takayanagi.shl)
Sato, K., Hida, S., Takayanagi, H., Yokochi, T., Kayagaki, N., Takeda, K., Yagita, H.,
Okumura, K., Tanaka, N., Taniguchi, T. and Ogasawara, K. Antiviral response by
natural killer cells through TRAIL gene induction by IFN-a b. Eur J Immunol. 31,
3138-3146 (2001)
Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A.,
Yokochi, T., Oda, H., Tanaka, K., Nakamura, K. and Taniguchi, T. T-cell-mediated
regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-g.
Nature. 408, 600-605 (2000)
Takayanagi, H., Iizuka, H., Juji, T., Nakagawa, T., Yamamoto, A., Miyazaki, T.,
Koshihara, Y., Oda, H., Nakamura, K. and Tanaka, S. Involvement of receptor
activator
of
nuclear
factor
kB
ligand/osteoclast
differentiation
factor
in
osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum. 43,
259-69 (2000)
Hida, S., Ogasawara, K., Sato, K., Abe, M., Takayanagi, H., Yokochi, T., Sato, T.,
Hirose, S., Shirai, T., Taki, S. and Taniguchi, T. CD8+ T cell-mediated skin disease in
mice lacking IRF-2, the transcriptional attenuator of interferon-a b signaling.
Immunity. 13, 643-655(2000)
Miyazaki, T., Katagiri, H., Kanegae, Y., Takayanagi, H., Sawada, Y., Yamamoto, A.,
Pando, M. P., Asano, T., Verma, I. M., Oda, H., Nakamura, K. and Tanaka, S.
Reciprocal role of ERK and NF-kB pathways in survival and activation of osteoclasts.
J Cell Biol. 148, 333-42 (2000)
Miyazaki, T., Takayanagi, H., Isshiki, M., Takahashi, T., Okada, M., Fukui, Y., Oda, H.,
Nakamura, K., Hirai, H., Kurokawa, T. and Tanaka, S. In vitro and in vivo suppression
of osteoclast function by adenovirus vector-induced csk gene. J Bone Miner Res. 15,
41-51 (2000)
Nakagawa, T., Tanaka, S., Suzuki, H., Takayanagi, H., Miyazaki, T., Nakamura, K. and
Tsuruo, T. Overexpression of csk gene suppresses tumor metastasis in vivo. Int J
Cancer. 88, 384-91 (2000)
Takayanagi, H., Juji, T., Miyazaki, T., Iizuka, H., Takahashi, T., Isshiki, M., Okada, M.,
Tanaka, Y., Koshihara, Y., Oda, H., Kurokawa, T., Nakamura, K. and Tanaka, S.
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to
synoviocytes and osteoclasts. J Clin Invest. 104, 137-46 (1999)
Tanaka, S., Takahashi, T., Takayanagi, H., Miyazaki, T., Oda, H., Nakamura, K., Hirai,
H. and Kurokawa, T. Modulation of osteoclast function by adenovirus vector-induced
epidermal growth factor receptor. J Bone Miner Res. 13, 1714-20 (1998)
Yoshida, T., Horiuchi, T., Sakamoto, H., Inoue, H., Takayanagi, H., Nishikawa, T.,
Yamamoto, S. and Koshihara, Y. Production of parathyroid hormone-related peptide
by synovial fibroblasts in human osteoarthritis. FEBS Lett. 433, 331-4 (1998)
Takayanagi, H., Oda, H., Yamamoto, S., Kawaguchi, H., Tanaka, S., Nishikawa, T.,
and Koshihara, Y. A new mechanism of bone destruction in rheumatoid arthritis:
synovial fibroblasts induce osteoclastogenesis. Biochem Biophys Res Commun. 240,
279-86 (1997)
100 other review articles in Japanese
Commentary article
Boyce, B.F. and Xing, L. Bruton and Tec: New Links in Osteoimmunology.
Cell Metab. 7, 283-285 (2008)
Lipsky, P.E. Osteoimmunology: a new area of rheumatology research.
Nat Clin Pract Rheumatol. 4, 111 (2008)
Bell, E. Innate immunity: New role for cathepsin K.
Nat Rev Immunol. 8, 166-167 (2008)
Krieg, AM and Lipford, GB. The Toll of Cathepsin K Deficienty.
Science. 319 (2008)
TH17 cells are a potential therapeutic target in autoimmune arthritis.
Nat Clin Pract Rheumatol. 3, 69 (2007)
Ahmad, S.
T Helper Cells: TH17 cells linked to bone destruction.
Nat Rev Immunol. 7, 6-7 (2007)
Williams, R.
Bone destruction by Th17
J Exp Med. 203, 2567 (2006)
Van Epps, H. L.
NFATc1 self-promotes to build bone.
J Exp Med. 202, 1156 (2005)
Baron, R.
Arming the osteoclast.
Nat Med. 10, 458-60 (2004)
Alliston, T, and Derynck, R. Interfering with bone remodelling.
Nature. 416, 686-7 (2002)
Arron, J.R and Choi, Y.
Bone versus immune system.
Nature. 408, 535-6 (2000)
Presentations
1. Invited speakers
Hiroshi Takayanagi: Anti-Osteoclast Therapy for Bone Destruction in Inflammation
The 9th World Congress on Inflammation, 2009.7.10, Tokyo
Hiroshi Takayanagi: TNF-α and Bone Destruction in Arthritis - from the Viewpoint
of Basic Research The 9th World Congress on Inflammation, 2009.7.8, Tokyo
Hiroshi Takayanagi: Molecular mechanism in osteoclastogenesis
JSPS Core-to-Core Program International Workshop on Advanced Bone and Joint
Science (ABJS) 2008.12.4, Tokyo
Hiroshi Takayanagi: Bone and Immune System
Annual Meeting of Korean Endocrine Society 2008.11.8 Jeju, Korea
Hiroshi Takayanagi: Th17 Cytokines and their Effects
2008 ACR Basic Research conference 2008.10.24 San Francisco
Hiroshi Takayanagi: Osteoclasts in Arthritis and Osteoimmunology
13th Congress of the Asia Pacific League of Associations for Rheumatology 2008.9.23,
Yokohama
Hiroshi Takayanagi: Use of mouse genetics in bone biology and osteoimmunology.
EMBO Practice Course on "Anatomy and Embryology of the Mouse" 2008.9.10,
Zagreb, Croatia
Hiroshi Takayanagi: Unexpected link between osteoclast and the immune system.
2nd International Conference on Osteoimmunology: Interactions of the Immune and
Skeletal Systems 2008.6.11, Rhodes, Greece
Hiroshi Takayanagi: Regulation of Osteoclastogenesis and Osteoimmunology
International Bone & Mineral Society Davos Workshops, 2008.3.10, Davos,
Switzerland
Hiroshi Takayanagi: Molecular mechanism of osteoclast differentiation.
JSPS Core-to-Core Program, The First International Workshop on Advanced Bone and
Joint Science (ABJS) 2007, 2007.10.29, Tokyo
Hiroshi Takayanagi: Bone Destruction in Arthritis and Osteoimmunology.
4th International Symposium of Chosun University Hospital, 2007.9.29, Kyang Ju,
Korea
Hiroshi Takayanagi: Mechanism of osteoclast differentiation
Meet-the-Professor Session
The 29th Annual Meeting of the American Society for Bone and Mineral Research
2007.9.19, Honolulu, U.S.A.
Hiroshi Takayanagi: Role of NFAT in Osteoclast Formation
2nd Conference on Skeletal Biology and Medicine 2007.4.26, New York, U.S.A.
Hiroshi Takayanagi: Molecular mechanism of osteoclast differentiation and
osteoimmunology.
INSERM The 2nd Annual Meeting of PRO-A, Institut Curie. 2007.1.25, Paris, France
Hiroshi Takayanagi: Interaction between bone and the immune system.
Prize Lecture, International Conference on Progress in Bone and Mineral Research on
the occasion of the Awarding of the 2006 International Research Prize, 2006.11.17,
Vienna, Austria
Hiroshi Takayanagi: The regulation of bone metabolism by the immune system.
International Conference on Progress in Bone and Mineral Research 2006, The
Austrian Society for Bone and Mineral Research, 2006.11.16, Vienna, Austria
Hiroshi Takayanagi: Immune Mechanisms in Osteoclastogenesis
3rd IOF Asia-Pacific Regional Conference on Osteoporosis and 16th Annual Meeting
of the Australian & New Zealand Bone & Mineral Society, 2006.10.23, Port Douglas,
Australia
Hiroshi Takayanagi: Transcription Factors in Osteoclast Differentiation.
The 28th Annual Meeting of the American Society for Bone and Mineral Research.
2006.9.15, Philadelphia, U.S.A.
Hiroshi Takayanagi: Novel signaling pathways and therapeutic targets in osteoclasts.
1st International Conference on Osteoimmunology, 2006.5.31, Crete, Greece
Hiroshi Takayanagi: Mechanisms of osteoclast activation by RANKL and
co-stimulatory ligands.
European Symposium on Calcified Tissues, 2006.5.12, Prague, Czech Republic
Hiroshi Takayanagi: Regulation of osteoclasts by the immune system.
5th Global Arthritis Research Network (GARN), 2005.9.16, Vienna, Austria
Hiroshi Takayanagi: Regulation of osteoclast differentiation by NFATc1
The 2005 Gordon Conference on Bones and Teeth, 2005.7.11, University of New
England, U.S.A.
Hiroshi Takayanagi: The Role of NFAT in osteoclast differentiation
European Calcified Tissue Society and International Bone and Mineral Society (ECTS,
IBMS), 2005.6.26, Geneva, Switzerland
Hiroshi Takayanagi: Osteoimmunology—a new regulatory mechanism
Annual European Congress of Rheumatology "EULAR 2005", 2005.6.8, Vienna
Hiroshi
Takayanagi:
Integration
of
RANKL
Signaling
by
NFATc1
in
Osteoclastogenesis.
26th Annual Meeting of American Society for Bone and Mineral Research, 2004.10.3,
Seattle
Hiroshi Takayanagi: Novel regulators of RANKL-induced osteoclastogenesis
The 11th Asia Pacific League of Associations for Rheumatology Congress, 2004.9.15,
Jeju Island, Korea
Hiroshi Takayanagi: Regulation of RANKL signaling in osteoimmunology
2nd Wittgenstein Conference “Bone and Cartilagein Health and Disease”
2003.10.18 Vienna
Hiroshi Takayanagi: Regulation of RANKL signaling in arthritic bone destruction
3rd Global Arthritis Research Network (GARN), 2003.9.15 Miyazaki
Hiroshi Takayanagi: Regulation of RANKL signaling in osteoclast differentiation
1st joint meeting of International Bone and Mineral Society/Japan Bone and Mineral
Society, Plenary lecture, 2003.6.3 Osaka, Japan
Hiroshi Takayanagi: The positive and negative regulation of RANKL signaling in
osteoclastogenesis
11th International Rheumatology Symposium, 2003.4.25 Tokyo, Japan
Hiroshi Takayanagi: Regulatory mechanism of RANKL signaling
Bone Frontier Seminar, 2003.2.22 Shizuoka, Japan
2. Major Presentations (international meeting)
T. Koga, M. Shinohara, K. Okamoto, K. Arai, H. Takayanagi
Tec kinases form an osteoclastogenic signaling complex with SLP adaptor proteins.
The 13th Asia Pacific League of Associations for Rheumatology Congress、2008.9.26,
Yokohama
K. Okamoto, M. Asagiri, T. Hirai, T. Kunigami, H.J. Gober, K. Nishikawa, K. Aoki, K.
Ohya, S. Kato, P. Saftig, H. Takayanagi
A Novel Role of Cathepsin K In Autoimmunity: Regulation of Toll-Like Receptor 9
signaling in Dendritic Cells
The 13th Asia Pacific League of Associations for Rheumatology Congress、2008.9.24,
Yokohama
K. Okamoto, M. Asagiri, T. Hirai, T. Kunigami, H. J. Gober, K. Nishikawa, K. Aoki, K.
Ohya, S. Kato, P. Saftig, H. Takayanagi.
Osteoclast-Independent Function of Cathepsin K: Regulation of Toll-like Receptor 9
Signaling in Autoimmunity.
The 30th Annual Meeting of the American Society for Bone and Mineral Research.
2008.9.12,13, Montreal, Canada
M. Shinohara, T. Koga, K. Okamoto, H. Takayanagi: Tec Tyrosine Kinases Are
Essential For Osteoclast Differentiation.
The 29th Annual Meeting of the American Society for Bone and Mineral Research.
2007.9.19, Honolulu, U.S.A.
A. Suematsu, K. Sato, T. Nakashima, S. Takemoto-Kimura, K. Aoki, K. Ohya, A.
Yamaguchi, T. A. Chatila, H. Bito, H. Takayanagi. The CaMK-CREB Pathway
Regulates Osteoclast Differentiation and Function. (Poster)
The 29th Annual Meeting of the American Society for Bone and Mineral Research.
2007.9.19, Honolulu, U.S.A.
S. Ochi, M. Shinohara, K. Sato, H. Takayanagi. Immunoreceptor signaling and TNF-α
-induced acceleration of osteoclastgenesis in rheumatoid arthritis.
The 12th Asia Pacific League of Associations for Rheumatology Congress, 2006.8.3,
Kuala Lumpur, Malaysia
T. Koga, K. Nakashima, H. Takayanagi. Cooperative regulation of bone formation by
NFAT and Osterix.
1st International Conference on Osteoimmunology, 2006.5.29, Crete, Greece
M. Asagiri, T. Koga, K. Sato, H. Takatsuna, K. Umezawa, H. Takayanagi. Regulation
of bone metabolism by NF-κB and NFAT
KEYSTONE SYPOSIA Mar. 24, 2006, Banff, Canada
T. Koga, M. Inui, A. Suematsu, T. Taniguchi, T. Takai, H. Takayanagi.
ITAM-mediated costimulatory signals cooperate with RANKL for osteoclastogenesis
26th Annual Meeting of American Society for Bone and Mineral Research, 2004.10.3,
Seattle (Young Investigator's Award)
H. Takayanagi
Leflunomide inhibits bone destruction by interfering with RANKL signaling and
osteoclastogenesis
Annual European Congress of Rheumatology "EULAR 2004", Berlin, 2004.6.11
H. Takayanagi, K. Sunhwa and T. Taniguchi
RANKL signaling network in positive and negative regulation of osteoclastogenesis
Meeting on genetic and molecular biology of skeletal development, Lucca, Italy
2002.10.14
H. Takayanagi; S. Kim, K. Sato, S. Muraki, H. Suzuki, A. Takaoka and T. Taniguchi
Regulation of osteoclastogenesis by signaling cross-talk between RANKL and IFN
system
Keystone meeting, NF-kB:Bench to bedside Keystone 2002.3.1
H. Takayanagi, H. Oda, T Taniguchi and K Nakamura. Mechanism of bone destruction
in arthritis: Defective control of bone resorption by the immune system.
American College of Rheumatology 65th Annual Scientific Meeting, San Francisco,
2001.11.13
H. Takayanagi, H. Oda, K. Nakamura and T. Taniguchi
T-cell regulation of osteoclastogenesis by RANKL and IFN-gamma
23th Annual meeting of the American Society for Bone and Mineral Research,
Phoenix, 2001.10.4
H. Takayanagi, S. Tana, K. Ogasawara, S. Hida, K. Nakamura and T. Taniguchi
Osteoclasts generated from synoviocytes: New therapeutical targets of arthritic bone
destruction
Kennedy Institute of Rheumatology Oxford seminar: "From the laboratory to the
clinic" Oxford, UK, 2000.9.23
H. Takayanagi, T. Juji, T. Miyazaki, H. Iizuka, H. Oda, K. Nakamura and S. Tanaka
Amelioration of adjuvant arthritis by adenovirus-mediated transfer of csk gene.
62nd Annual Scientific Meeting of the American College of Rheumatology. San Diego.
1998.11.10
H. Takayanagi, T. Juji, T. Miyazaki, H. Iizuka, H. Oda Y., Tanaka, K. Nakamura and S.
Tanaka
Suppression of bone destruction in adjuvant arthritis by adenovirus-mediated transfer
of csk gene to osteoclasts and synoviocytes.
Second joint meeting of the American Society for Bone and Mineral Research and the
International Bone and Mineral Society. San Francisco. 1998.12.5
H. Takayanagi, T. Takahashi, H. Hirai, T. Kurokawa and S. Tanaka
Modulation of osteoclast function by adnovirus vector-induced epidermal growth
factor receptor, 19th Annual meeting of the American Society for Bone and Mineral
Research, Cincinatti, 1997.9.14
Other presentations (in Japan)
Invited speakers
The 27th Annual Meeting of the Japanese Society for Bone and Mineral Research,
Osaka International Convention Center, 2009.7.24, Osaka
The 3rd Global COE International Symposium, Tokyo Medical and Dental University,
2009.6.10, Tokyo
The Annual Symposium of IFReC (Immunology Frontier Research Center), Osaka
University, 2009.2.12, Osaka
Annual meeting of Japanese Society for Bone and Mineral Research
2008.10.30,31
Annual meeting of Japanese Society of Hematology, 2008.10.10
Annual meeting of Japanese Society for Bone Morphometry 2008.7.26
Annual meeting of Japanese Orthopaedic Association 2008.5.22
Annual meeting of Japan College of Rheumatology 2008.4.22, 23
Annual meeting of Japan Society for Clinical Immunology 2007.10.19
Annual meeting of Japanese Society of Inflammation and Regeneration 2007.8.3
Annual meeting of Japanese Society for Bone and Mineral Research
2007.7.20
Annual meeting of Japanese Society of Interferon & Cytokine Research 2007.7.5
Annual meeting of Japanese Society for Bone Morphometry 2007.6.1
Annual Orthopaedic Research Meeting of the Japanese Orthopaedic Association
2006.10.19
Annual meeting of Japanese Society for Bone and Mineral Research
2006.7.19-21
Annual meeting of Japanese Society of Inflammation and Regeneration 2006.7.11-12
Annual meeting of Japanese Society for Bone and Mineral Research 2006.7.6-7
Annual meeting of Japanese Orthopaedic Association 2006.5.21
Annual meeting of Japan College of Rheumatology 2006.4.24-25
Annual meeting of Japanese Society for Bone and Mineral Research 2005.7.21-22
Annual meeting of Japan College of Rheumatology 2005.4.19
Annual meeting of Molecular Biology Society of Japan, 2004.12.8
Annual meeting of Japanese Society for Immunology, 2004.12.2
Annual meeting of Japanese Association for Dental Research, 2004.11.27
Annual meeting of Japan Society for Clinical Immunology, 2004.10.8
Annual meeting of Japanese Society of Inflammation and Regeneration 2004.7.13
Annual meeting of Japan College of Rheumatology 2004.4.15
Annual meeting of Japanese Pharmacological Society 2004.3.9
Annual meeting of Japanese Society of Molecular Medicine 2003.7.10
Annual meeting of Japanese Society of Bone Morphometry 2003. 7.5
Annual meeting of Japan College of Rheumatology 2003.4.24
Annual meeting of Japanese society of Immunology 2002.12.5
Annual meeting of Japanese society of Biochemistry 2002.10.16
Annual meeting of Japanese society of Clinical Rheumatology 2001.11.26
Annual meeting of Japanese society of Molecular Biology 2001.12.11
Annual meeting of Japanese society of Clinical Immunology 2000.9.28
Meeting presentations
Annual meeting of Japanese society of Bone and Mineral Research 2001.8.10
Annual meeting of Japanese society of Orthopaedic surgery 2000.9.29
Annual meeting of Japanese society of Bone and Mineral Research 2000.7.22
Annual meeting of Japanese society of Rheumatology 2000.5.13
Annual meeting of Japanese society of Rheumatology 1999.6.3
Annual meeting of Japanese society of Inflammation 1998.9.3
Annual meeting of Japanese society of Orthopaedic surgery 1998.9.25
Annual meeting of Japanese society of Bone and Mineral Research 1998.8.5
Annual meeting of Japanese society of Rheumatology 1998.5.7
Annual meeting of Japanese society of Orthopaedic surgery 1997.10.16
Annual meeting of Japanese society of Bone and Mineral Research 1997.7.26