Download 19.09 Replication of HIV Slide number: 4 Nucleus Host cell

19.09 Replication of HIV
Glycoprotein
Capsid
Reverse transcriptase (RT)
RNA
Viral envelope
Slide number: 1
Host cell
1
50 nm
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Viral RNA
2
RNA-DNA hybrid
3
Nucleus
DNA
4 Double stranded DNA is
incorporated into host cell’s
genome.
4
Chromosomal DNA
5
Viral DNA
RNA
3 New DNA strand serves as a
template for complementary
DNA strand.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
Viral proteins
6
6 mRNA translated into HIV
proteins in cytoplasm.
7
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 2
50 nm
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 3
Glycoprotein
Capsid
Reverse
transcriptase (RT)
RNA
Viral envelope
50 nm
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 4
Host cell
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 5
Host cell
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 6
Host cell
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 7
Host cell
1
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 8
Host cell
1
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 9
Host cell
1
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 10
Host cell
1
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 11
Host cell
1
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
Viral RNA
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 12
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Viral RNA
2
RNA-DNA hybrid
Nucleus
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 13
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
RNA-DNA hybrid
3
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
DNA
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 14
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
DNA
4
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 15
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
4
Chromosomal DNA
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
Viral DNA
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 16
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5
RNA
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 17
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
Viral proteins
6
6 mRNA translated into HIV
proteins in cytoplasm.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 18
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
Viral proteins
6 mRNA translated into HIV
proteins in cytoplasm.
7
7 Capsids surround new viral
RNA genomes.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 19
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
Viral proteins
6 mRNA translated into HIV
proteins in cytoplasm.
7
7 Capsids surround new viral
RNA genomes.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 20
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 21
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 22
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 23
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 24
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 25
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 26
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 27
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 28
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 29
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
19.09 Replication of HIV
Slide number: 30
Host cell
1 Virus binds receptors on cell
membrane, and enters cell.
Enzymes remove proteins of
viral capsid.
2 RT catalyzes formation of DNA
complementary to viral RNA.
Nucleus
3 New DNA strand serves as a
template for complementary
DNA strand.
4 Double stranded DNA is
incorporated into host cell’s
genome.
5 Viral genes transcribed into
mRNA. Some viral DNA copied
as the RNA genome for virions.
6 mRNA translated into HIV
proteins in cytoplasm.
7 Capsids surround new viral
RNA genomes.
8
8 New viruses bud from host cell.
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.