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Table, Supplemental Digital Content 2. Patient characteristics on admission, and at recovery SEPTIC ARTHRITIS (N 134) OSTEOMYELITIS (N106) OM+SA 1 (N 25) S. aureus Other bacteria S. aureus Other bacteria S. aureus Other bacteria --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N 81 53 99 7 19 6 Gender, Males/Females 49/32 30/23 65/34 6/1 5/14 6/- Age in years, median (±IQR2) 10 (6-12) 2 (1-5) 10 (7-12) 10 (3-14) 6 (3-10) 4 (4-13) First symptoms, days, median (±IQR) 3 (1-4) 2 (1-4) 4 (2-6) 2 (2-3) 3 (2-5) 2 (2-3) 81 - 23 16 11 33 99 - 1 5 1 - 19 - 2 4 - 20 34 27 21 30 2 22 30 47 1 2 4 11 5 3 5 1 - Initial value, mean (±SEM5) C-reactive protein, CRP, mg/L 81 (5) Erythrocyte sedimentation rate, ESR, mm/H 50 (3) 94 (8) 64 (6) 80 (6) 45 (2) 120 (35) 25 (4) 87 (15) 60 (6) 157 (24) 78 (26) Duration of antimicrobial therapy Intravenous, median, days (±IQR) Total, median, days (±IQR) 4 (3-5) 26 (10-30) 3 (3-3) 26 (12-30) 3 (3-4) 21 (20-30) 4 (3-4) 20 (18-23) 6 (5-9) 25 (20-31) 7 (5-9) 21 (10-65) CRP normalization, days (±SEM) ESR normalization, days (±SEM) Hospital stay, days (±SEM) 10 (1) 24 (3) 11 (1) 11 (1) 27 (4) 13 (1) 8 (1) 18 (1) 10 (0.5) 11 (3) 27 (4) 11 (2) 15 (3) 34 (9) 13 (2) 20 (5) 49 (2) 11 (3) Causative agent Staphylococcus aureus Haemophilus influenzae type b Streptococcus pyogenes Streptococcus pneumoniae Other Agent cultured from Bone/joint and blood Bone/joint only Blood only4 - Long-term sequelae 1 0 1 0 0 1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------1 Osteomyelitis with adjacent septic arthritis 2 Interquartile range 3 Meningococcus B, Meningococcus W 135, Streptococcus G 4 With indisputable signs and symptoms of acute septic osteoarticular infection 5 Standard error of mean