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The YongLin Healthcare Symposium series – The 1st Meeting on “DNA Processes, Drugs and Cancer” Agenda The YongLin Healthcare Symposium series – The 1st Meeting on “DNA Processes, Drugs and Cancer” Time Day 1: Sunday, 27th November 8:30am – Registration 9:00am 9:00am – 9:20am Welcome and Keynote Address Keynote Address: 9:00am – 9:20am President Pan-Chyr Yang, National Taiwan University Title: Introduction to the YongLin Healthcare Symposium series, Taiwan Biomedical Ecosystem and Excellence 9:20am – Group Photos 9:30am 9:30am – 10:30pm Keynote Session Moderator: Tsai-Kun Li (30 min Talk) Keynotes Speakers: 9:30am – 10:00am Prof. Ann-Lii Cheng, , National Taiwan University Title: The History of Anticancer Therapy Keynotes Speakers: 10:00am – 10:30am Prof. Ming-Daw Tsai, Academic Sinica, Taiwan Title: The evolution view of DNA polymerase 10:30am – 10:45am Coffee Break 10:45am – 12:00pm Plenary Session 1: Tumor Heterogeneity and Therapy Resistance Moderator: James Chih-Hsin Yang (20 min Talk + 5-min Discussion) Prof. Christian Reinhardt, Germany 10:45am – 11:10pm Title: Exploring the synergistic drug interactome for the treatment of cancer - a view from the DDR perspective Prof. Seishi Ogawa, Kyoto University, Japan 11:10am – 11:35pm Title: Immunotherapy and emerging resistance: Abberant OD-L1 expression through 3'-UTR disruption in multiple cancers Prof. Jean Sebastien Hoffmann, Germany 11:25am – 12:00pm Title: Deregulated DNA replication program as a source of therapeutic resistance in Leukemia 12:00pm – Lunch and Poster Viewing 13:30am Plenary Session 2: DNA processes, Tumor Microenvironment and 13:30pm – Carcinogenesis 15:10pm Moderator: Huei-Wen Chen (20 min Talk + 5-min Discussion) Prof. Shosuke Kawanishi, Japan 13:30pm – 13:55pm Title: DNA damages and Inflammation-related Carcinogenesis: biochemical and clinical aspects Prof. Zee-Fen Chang, National Taiwan University, Taiwan 13:55pm – 14:20pm Title: DNA “mis-repair” resulting from deficiencies in quality and quantity of nucleotides Prof. Rosselli Filippo, UMR 8200, Institut Gustave -Roussy, Villejui, France 14:20pm – 14:45pm Title: The Fanconi anemia pathway acts downstream Microphtalmia transcription factor to maintain proliferation and survival of melanoma cells and to ensure cell resistance to DNA damage and inflammation 14:45pm – 15:10pm Prof. Shigetsugu Hatakeyama, Hokkaido University, Japan Title: TRIM ubiqutin ligases in inflammation and carcinogenesis 15:10pm – Coffee Break 15:30pm Plenary Session 3: Chromatin Dynamics and Biology in anticancer 15:30pm – intervention 17:10pm Moderator: Nei-Li Chan (20 min Talk + 5-min Discussion) Prof. Gaëlle Legube, BCMCP-CNRS UMR5088 University of Toulouse, 15:30pm – 15:55pm France Title: Chromatin and chromosome dynamics during DNA Double Strand Break repair Prof. Nei-Li Chan, College of Medicine, National Taiwan University 15:55pm – 16:20pm Title: Structure-based design of new topoisomerase-targeting intervention 16:20pm – 16:45pm 16:45pm – 17:10pm Prof. Françoise Dantze, IREBS-UMR7242-BSC, France Title: Therapeutic significance of PARP3 in cancer therapy Prof. Jing-Jer Lin, College of Medicine, National Taiwan University Title: Telomere Biology and Chromsome Stability in Cancer 18:00pm 20:00pm Banquet Time Day 2: Monday, 28th November 9:00am – Plenary Session 4: Transcription Programming and Repair Factors 10:15am 9:00am – 9:25am Moderator: Tsai-Kun Li (20 min Talk + 5-min Discussion) Prof. Jean-Marc Egly, IGBMC, France Title: Transcription coupled DNA repair and DNA binders Prof. Hung-Yuan Peter Chu, National Taiwan University 9:25am – 9:50am Title: Deciphering the functional and mechanistic role of homologous recombination in biology Prof. Benjamin Chen, University of Texas Southwestern (UTSW) 9:50am – 10:15am Medical Center, USA Title: DNA-PK and TRIM28 in transcription programming and Gene Expression 9:00am – 10:15am Prof. Sheau-Yann Shieh, Academia Sinica, Taiwan Title: Checkpoint signaling in Cancer Biology 10:15am – Coffee Break 10:30am 10:30am – 12:10pm Plenary Session 5: DNA metabolism in caner and aging Moderator: Shu-Chun Teng (20 min Talk + 5-min Discussion) Prof. Bjorn Schumacher, Research Center / CECAD 10:30am – 10:55pm Forschungszentrum, Cologne, Germany Title: Cell-non-autonomous DNA damage responses in cancer and aging 10:55am – 11:20pm Prof. Shu-Chun Teng, , National Taiwan University Title: The evolution view of DNA polymerase 11:20am – 11:45pm Prof. Steven Lin, Academia Sinica, Taiwan Title: Understanding DNA repair mechanism to enable efficient Cas9-mediated homologous recombination 11:45am – 12:10pm Prof. Sheau-Yann Shieh, Academia Sinica, Taiwan Title: Checkpoint signaling in Cancer Biology 12:10pm – Close Ceremony and Adjourn 12::20pm Optional Tours: 12:30pm – 18:00pm I. Collaborative & Institutional Visiting II. City Tours