Download 2615-2623 March 15, 2012

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

Document related concepts
no text concepts found
Transcript
Mature erythrocyte membrane homeostasis is
compromised by loss of the GATA1-FOG1 interaction
by Atsushi Hasegawa, Ritsuko Shimizu, Narla Mohandas, and Masayuki Yamamoto
Blood
Volume 119(11):2615-2623
March 15, 2012
©2012 by American Society of Hematology
V205GR are prone to die from massive anemia during the perinatal period.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Erythroid phenotypes of V205GR neonates.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Abnormal appearance of V205GR characterized as spherocytic hemolytic anemia.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Expression of majority of membrane proteins was reduced in V205GR erythrocytes.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Expression of several genes coding for membrane proteins was selectively reduced in V205GR
erythrocytes.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
In vivo binding of GATA1 to the membrane protein genes.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Erythroid phenotypes of V205GR adult mice.
Atsushi Hasegawa et al. Blood 2012;119:2615-2623
©2012 by American Society of Hematology
Related documents