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Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction by Atsushi Hasegawa, Ritsuko Shimizu, Narla Mohandas, and Masayuki Yamamoto Blood Volume 119(11):2615-2623 March 15, 2012 ©2012 by American Society of Hematology V205GR are prone to die from massive anemia during the perinatal period. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology Erythroid phenotypes of V205GR neonates. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology Abnormal appearance of V205GR characterized as spherocytic hemolytic anemia. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology Expression of majority of membrane proteins was reduced in V205GR erythrocytes. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology Expression of several genes coding for membrane proteins was selectively reduced in V205GR erythrocytes. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology In vivo binding of GATA1 to the membrane protein genes. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology Erythroid phenotypes of V205GR adult mice. Atsushi Hasegawa et al. Blood 2012;119:2615-2623 ©2012 by American Society of Hematology