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Transcript 
Chymotrypsin
Proteases
Class
Nucleophile(s)
Base
Covalent
Intermediate
Serine protease
Ser/water
His
Yes
Cysteine protease
Cys/water
His
Yes
Aspartyl protease
water
Asp
No
Metalloprotease (Zn)
water
Glu
No
Proton Shuttle in Carbonic Anhydrase
RNA Secondary and Tertiary Structure
Hepatitis Delta Virus Ribozyme
Hydrolysis of a phosphodiester bond by a Ribozyme
in vitro Evolution of a Ribozyme
Genetic diversity
(affinity chromatography)
More genetic diversity!
(RT-PCR)
Clone and test for
Ribozyme that
Hydrolyzes ATP
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