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Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification by Alicia D. Volkheimer, J. Brice Weinberg, Bethany E. Beasley, John F. Whitesides, Jon P. Gockerman, Joseph O. Moore, Garnett Kelsoe, Barbara K. Goodman, and Marc C. Levesque Blood Volume 109(4):1559-1567 February 15, 2007 ©2007 by American Society of Hematology Rearranged immunoglobulin variable region heavy chain and light chain sequence analysis of 43 single sorted cells from CLL subject 012. Alicia D. Volkheimer et al. Blood 2007;109:1559-1567 ©2007 by American Society of Hematology Rearranged immunoglobulin variable region heavy chain and light chain sequence analysis of 20 single sorted cells from CLL subject 151. Alicia D. Volkheimer et al. Blood 2007;109:1559-1567 ©2007 by American Society of Hematology Genealogic analysis of CLL-cell subgroups from CLL subject 012. Alicia D. Volkheimer et al. Blood 2007;109:1559-1567 ©2007 by American Society of Hematology Genealogic analysis of CLL-cell subgroups from CLL subject 151. Alicia D. Volkheimer et al. Blood 2007;109:1559-1567 ©2007 by American Society of Hematology P values for ratios of replacement and silent mutations (R/S) in the FR and CDR regions of each CLL-cell subgroup from subjects. Alicia D. Volkheimer et al. Blood 2007;109:1559-1567 ©2007 by American Society of Hematology
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