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NO
.
p21 (Waf1/Cip1)
Cell Cycle
APC/C
CDC20
p38
MAPK
CDC25B
CCNE
CDK2
CCND
CDK4,6
CCNA
CDK2
Rb
CCNA
CDK1
+p
CCNB
CDK1
+p
+p
-p
+p
+p
PLK
CDC6
ORC
Ubiquitin
mediated
proteolysis
Rb
E2F1
DP1
DNA
APC/C
Cdh1
DNA
biosynthesis
DNA
Activation
S-phase
proteins
Inhibition
G1
S
G2
x
M
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