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NO . p21 (Waf1/Cip1) Cell Cycle APC/C CDC20 p38 MAPK CDC25B CCNE CDK2 CCND CDK4,6 CCNA CDK2 Rb CCNA CDK1 +p CCNB CDK1 +p +p -p +p +p PLK CDC6 ORC Ubiquitin mediated proteolysis Rb E2F1 DP1 DNA APC/C Cdh1 DNA biosynthesis DNA Activation S-phase proteins Inhibition G1 S G2 x M