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Geert Leroux-Roels BIOGRAPHICAL SKETCH NAME POSITION AND AFFILIATION LEROUX-ROELS Geert Director, Centre for Vaccinology Ghent University and Hospital De Pintelaan 185, B-9000 GENT Belgium EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY Ghent University MD 1976 medicine Ghent University Ph.D. (1) 1981 Immunology, clinical chemistry Ghent University Ph.D. (2) 1986 immunology Research Interest ( not more than 100 words): In the past 25 years, Geert Leroux-Roels has been studying the human immune response towards the hepatotropic viruses HBV and HCV. His team contributed to the understanding of the mechanisms of non-responsiveness to hepatitis B vaccine. Since the discovery of HCV in 1989, Dr. Leroux-Roels and colleagues are examining the human immune response towards HCV in order to understand the mechanisms underlying resolution and persistence. Recently a small animal model (human liver in uPA-SCID mouse) has been developed that allows for the “in vivo” study of HBV and HCV infections and the evaluation of novel antiviral therapies. Key words: HBV, HCV, immune response, vaccine. Selected Publications (5 publications): 1. Depraetere S, Verhoye L, Leclercq G, Leroux-Roels G. Human B cell growth and differentiation in the spleen of immunodeficient mice. J. Immunol 2001;166:2929-2936. 2. Meuleman P, Libbrecht L, De Vos R, de Hemptinne B, Gevaert K, Vandekerckhove J, Roskams T, Leroux-Roels G. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 2005;41:847-856. 3. Meuleman P, Libbrecht L, Wieland S, De Vos R, Habib N, Kramvis A, Roskams T, Leroux-Roels G. Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus. J Virol 2006;80:2797-2807. 4. Lindenbach B, Meuleman P, Ploss A, Vanwolleghem T, Syder A, McKeating J, Lanford R, Feinstone S, Major M, Leroux-Roels G, Rice C. Cell-culture grown hepatitis C is infectious in vivo and can be recultured in vitro. Proc Natl Acad Sci USA 2006;103:3805-3809. 5. Leroux-Roels I, Borkowski A, Vanwolleghem T, Dramé M, Clement F, Hons E, Devaster J-M, Leroux-Roels G. Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine. The Lancet (in press)