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From: Mechanistic Insights into Glaucoma Provided by Experimental Genetics The Cogan Lecture
Invest. Ophthalmol. Vis. Sci.. 2005;46(8):2650-2661. doi:10.1167/iovs.05-0205
Figure Legend:
Tyrosinase and DOPA modify angle development. Eyes of Cyp1b1 −/− mice have obvious angle abnormalities (compare
with Fig. 1B ). (A) In a pigmented eye (Tyr +/+), the trabecular meshwork (TM) is hypoplastic, and material resembling
Descemet’s membrane covers a portion of the TM (arrowheads). (B) In an albino eye (Tyr −/−), a very small Schlemm’s
canal may be present (arrowhead). There is no TM and the iris is attached to the cornea ( ). (C) l-DOPA administration
throughout development profoundly alleviates the developmental abnormalities in Cyp1b1 −/− mice. The higher the
severity grade, the more severe and the more extensive the abnormalities were. (D) Several genes that cause anterior
segment
dysgenesis
and/or glaucoma
possibly
modulate
DOPA in
levels
during
ocular development.
(A–C)
Reproduced
Date
of download:
8/3/2017
The
Association
for Research
Vision
and Ophthalmology
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© 2017.
All rights reserved.
from Libby RT, Smith RS, Savinova OV, et al. Modification of ocular defects in mouse developmental glaucoma models