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Legend to soundtracks for catalytic domains of cell signalling proteins. These melodies were produced by Dr. William Campbell ([email protected]) and are based on the hydrophobicity of the amino acids in each protein. High notes correspond to amino acids with high hydrophilicity while the low notes correspond to the most hydrophobic amino acids. The order of the musical notes follow the order of the amino acid residues in the sequence of each protein. Name of Music File Family of Cell Signalling Protein Represented PDB Name of Species Number Animation File Represented EGF receptor (671Epidermal growth factor 998).mid receptor catalytic domain PI3K phosphatididyl Phosphatidylinositol 3-kinase inositol 3-kinase.mid p110 Human protein-tyrosine- Protein-tyrosine phosphatase phosphatase 1b.mid 1B Protein kinase 1M17 PI3-kinase-related protein kinase Protein-tyrosine phosphatase 1E7V Human VH-1 related VH1-related dual specificity dual specificity protein phosphatase VHR phosphatase VHR.mid Dual specificity phosphatase 1J4X Human protein-serine phosphatase 2B calcineurin.mid Human phospholipase A2-11A.mid Name of Cell Signalling Protein Homo sapien Sus scrofa (Pig) Homo sapien Duration Note Tempo Scale Twice 1/4 100 Kyte Doolittle Full 1/8 120 Full 1/4 120 Tubular bells Full mark tremolo strings 1/8 70 Pentatonic Homo sapien 2-185 Bowed glass ProtHomo sapien SerPhosp.1AUI .mp4 PLA2.1BBC.m Homo sapien p4 2-185 Glockenspe Music box il Twice 1/4 100 Kyte Doolittle 2-144 Tremolo strings Full 1/8 60 Kyte Doolittle Protein-serine phosphatase 2B Protein-serine (calcinerin) phosphatase 1AUI Phospholipase A2 – IIA Phospholipase A2 1BBC Phospholipase C 1DJX PLC.1DJX.mp4 Rattus norvegicus (Rat) 133-756 Harpsicord Harp Full 1/8 50 Pentatonic 1CJK Nucl.Cycl.1CJ Canis K.mp4 familiaris (Dog) PDE.1UHO.mp Homo sapien 4 445-661 Glockenspe Vibraphone il Full 1/8 60 Kyte Doolittle 537-860 Koto Pan flute Full 1/8 50 Kyte Doolittle GProtein.1AS0 Rattus .mp4 norvegicus (Rat) Ras.121P.mov Homo sapien 1-353 Tremolo strings Harp Full 100 Kyte Doolittle 1-166 Harpsicord Glockenspeil Full 100 Caspase.1QTN Homo sapien .mp4 211-374 Fret noise 100 C major pentatonic C major Rat Phosphoinositide- Phosphatidylinositol-specific Specific Phospholipase phospholipase C-delta1 C-delta1.mid Adenylate cyclase V C1A domain.mid 1G1G ProteinKinase1 M17.mp4 PI3KRKinase.1 E7V.mp4 ProtTyrPhosp.1G1 G.mp4 DualProtPhosp .1J4X.mov Amino Acid DNA Protein Span Represented in Notes 671-998 Bowed Bowed glass glass 141-1102 Slow strings Tremolo strings 1-299 Slow strings Tremolo strings Adenylate cyclase type 5 C1A Nucleotide cyclase domain Human cGMP-specific cGMP-specific 3’,5’-cyclic 3'5' cyclic phosphodiesterase phosphodiesterase.mid Cyclic nucleotide phosphodiesterase 1UHO Rat G protein Gi alpha 1.mid G protein Gia1 subunit G protein alpha 1ASO Human H-ras.mid H-Ras Small GTPase 121P Human caspase 8 (version 2).mid Caspase 8 p18 Death protease 1QTN Tremolo strings Fret noise Full