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GEArray Q Series Mouse Neurotrophin and Receptors Gene Array Cat. No. (Rad / Non-Rad)* MM-018-2 / MM-018N-2 MM-018-4 / MM-018N-4 MM-018-12 / MM-018N-12 Kit 2 Arrays 4 Arrays 12 Arrays Description Each GEArray Q Series Mouse Neurotrophin and Receptors Gene Array kit is designed to profile the expression of 96 neurotrophic signaling molecules involved in growth, differentiation, survival, diseases, regeneration, and normal functions of the neuronal system. Six groups of genes are included in this array: neurotrophins and receptors, neuropeptides and receptors, growth factors involved in neuronal growth and differentiation, cytokines and receptors involved in neuronal signaling, signaling molecules indicative of activation of down stream pathways, and genes involved in neuronal apoptosis in response to neurotrophic factors. Through a simple side-by-side hybridization, you can determine simultaneously the expression profile of these genes in your samples, using the arrays and reagents provided Functional Gene Grouping Growth Factors & Receptors: Fgf2, Fgf9, Fgfr1, Ptn, Tgfa, Tgfb1, Tgfb1i1 Apoptosis Related Genes: Apaf1, Bax, Bcl2, Hsp25, Tnfrsf6, Trp53 Chemokine Receptors: Cmkar4 (CXCR4), Cx3cr1 Cytokines & Receptors: Il1b, Il1r1, Il6, Il6ra, Il6st, Il10, Il10ra, Il10rb, Lif, Lifr Neuropeptides & Receptors: Hcrt, Nmbr, Npff, Npy, Npy1r, Npy2r, Npy5r, Npy6r, Rfrp Neurotrophins & Receptors: Adcyap1r1, Artn, Bdnf, Cbln1, Cntf, Cntfr, Crh, Crhbp, Crhr, Crhr2, F2, Fus, Gdnf, Gfra1, Gfra2, Gfra3, Gfra4, Gmfb, Gmfg, Hcrtr1, Hcrtr2, Maged1, Maged3 (Tro), Mt3, Ngfb, Ngfr, Ngfrap1, Nr1i2, Nrg1, Ntf3, Ntf4/5, Ntrk1, Ntrk2, Ntrk3, Penk, Pnoc, Pspn, Ptger2, Snt-1, Snt-2, Tac1, Tnfrsf5, Tnfrsf6, Ucn, Vgf, Zfp110, Zfp369 Signaling Molecules: Atf2, Elk1, Ets1, Fos, Jun, Mef2c, Myc, Ncoa1, Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, Stat6, Rps6ka6 References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Altar CA. (1999) Neurotrophins and depression. Trends Pharmacol Sci. 20(2): 59-61. Baloh RH, Enomoto H, Johnson EM Jr, Milbrandt J. (2000) The GDNF family ligands and receptors - implications for neural development. Curr Opin Neurobiol.10 (1): 103-10. Barrett GL. (2000) The p75 neurotrophin receptor and neuronal apoptosis. Prog Neurobiol. 61(2): 205-29. Binder DK, Croll SD, Gall CM, Scharfman HE. (2001) BDNF and epilepsy: too much of a good thing? Trends Neurosci. 24:47-53. Bradford HF, Zhou J, Pliego-Rivero B, Stern GM, Jauniaux E. (1999) Neurotrophins in the pathogenesis and potential treatment of Parkinson's disease. Adv Neurol.80: 19-25. Farinas I. (1999) Neurotrophin actions during the development of the peripheral nervous system. Microsc Res Tech. 45(4-5): 233-42. Jankowsky JL, Patterson PH. (1999) Cytokine and growth factor involvement in long-term potentiation. Mol Cell Neurosci. 14(6): 273-86. Pierce RC, Bari AA. (2001) The role of neurotrophic factors in psychostimulant-induced behavioral and neuronal plasticity. Rev Neurosci. 12:95110. Schuman EM. (1999) Neurotrophin regulation of synaptic transmission. Curr Opin Neurobiol. 9(1): 105-9. Takahashi M. (2001) The GDNF/RET signaling pathway and human diseases. (2001) Cytokine Growth Factor Rev. 12:361-73. Weisenhorn DM, Roback J, Young AN, Wainer BH. (1999) Cellular aspects of trophic actions in the nervous system. Int Rev Cytol. 189:177-265. *When ordering, please specify Rad or Non-rad, kit size and price. Tel: 1.888.503.3187, 301.682.9200. Fax: 1.888.465.9859, 301.682.7300. Web: www.superarray.com