Download The Content of Certain Hormones in Blood Serum during

Georgian Biomedical Journal .
2017 May, Volume 1, Issue 5
The Content of Certain Hormones in Blood
Serum during Diabetes Mellitus Complicated
By Nephropathy
T. Makharadze, M. Gvalia, J. Topuria, M. Tugushi,
Kh.Tsitsiashvili
The Department of Therapy Specialization at Tbilisi State Medical University,
the Central Clinical Hospital, Tbilisi
Abstract
The results of our study has shown that: during insulin dependent or insulin dependent types of the diabetes
mellitus complicated by nephropathy, in the blood serum the level of rennin is higher in the case of type I
diabetes then in the case of type II. The elevation of the rennin contributes to the formation of stabile
hypertension. The concentration of aldosterone in the most cases is elevated and certain correlation to the
content of renin is observed. The changes of above mentioned hormone levels are as important as longer is
the duration of the disease. The role of the patients age has not appeared to be is strong correlation with the
levels of hormone. As for AKTH level changes, the correlation with aldosterone levels has not been observed.
Keywords: diabetes mellitus, nephropathy, hormones,
aldosterone
Introduction
A
s it is known, nephropathy is one of the most
frequent complications of the diabetes mellitus.
Frequency of this complication during type I
diabetes mellitus is 30-40%, while at type II diabetes
mellitus the percentage of the nephropathies is lower.
According to the data is revealed that 71% of
nephropathies are accompanied by hypertonia that in
most cases ends with functional failure of the kidney
[1.3.4].
Some authors consider that [2] hypertonia in the
patients with diabetes mellitus increases the risk of
nephropathy in the case of type II - diabetes (noninsulindependent). Certain authors have studied the
changes of renal functional abilities at insulin dependent
(type I) diabetes mellitus patients in relation with
nephropathy.
In the literature we couldn't find the dates about rennin
and angiotensin content in the blood serum during
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diabetes mellitus complicated by nephropathy. About
above-mentioned hormones the dates are not enough
as well in the connection with the diabetes mellitus
forms and the course of the disease.
From all above-mentioned the aim of our study was to
determine the content of rennin and aldosterone in the
blood serum during the diabetes mellitus complicated of
the above-mentioned hormones concentrations in the
serum during insulin dependent and non-insulin
dependent forms of the diabetes aggravated by
nephropathy taking under the consideration the severity
and the duration of the disease.
Materials and Methods
Serum rennin aldosterone and AKHT levels were
studied by radioimmunoassay using standard tests of
DSL firm. 166 patients suffered from diabetes mellitus
were under our observation. The cases of type I
diabetes were 90, type Ii - 76. From the cases of both
ISSN 2449-3031
Georgian Biomedical Journal .
2017 May, Volume 1, Issue 5
type of the diabetes we have created the separate
group comprising of 55 patients with diabetes
complicated by nephropathy. In this group (with
nephropathy) type I diabetes were in 34 cases, type II in
21 cases.
Research and Discussion
In relation with age has been observed the following
pattern: 10 patients from 20 to 30 years, 17-30-40
years, 28-40-50 years.
By study of rennin concentration in blood serum was
revealed that in the case of type I diabetes the level of
rennin is higher basically in the patients from 20 to 400
years old (should be mentioned, that the duration of
disease was one years). Decrease of rennin
concentration has not been established at all.
In the case of type II (among studied 21 patients) the
elevated levels of rennin were revealed only in 2 cases.
Besides, the age of the patients was also older.
Analysis of the patients data on the base of the disease
duration was revealed, that the elevated levels of the
rennin were observed in the patients with the 9-10 years
history of the disease.
The low content of rennin in blood serum was not
observed at II type diabetes as well.
As it was already mentioned at the type I and type II
diabetes the levels of aldosterone were also studied.
During type I diabetes among studied 34 patients the
elevated levels of aldosterone were revealed in 2
patients. The correlation between aldosterone levels
and age were not find. As for the duration of the disease
the high level of the aldosterone was revealed only in
one patient (28 years old) with a 1-year history of the
disease.
At type II diabetes the aldosterone levels were studied
in 21 patients. The elevation of the hormone level was
revealed only in 1 patient. In other cases aldosterone
levels were in the range of norms.
As it is known, rennin is the stimulator of the
aldosterone secretion, therefore it was considered of
high interest - either there was correlation between their
concentration or not. The results of the study revealed
some tendency to the elevation.
There are important data about AKTH role in the
secretion of aldosterone. The acrophaze of AKTH
precedes them acrophase of the aldosterone secretion.
Therefore the content of AKHT and aldosterone were
also studied at type I and type II diabetes mellitus, but
the important changes of findings were not observed.
Thus, the results of our study has shown that: at insulin
dependent and non-insulin dependent forms of the
diabetes mellitus complicated by nephropathy, in the
blood serum the levels of rennin is higher in the case of
type I, than in the case of type II. The elevation of the
rennin determines the formation of stabile hypertension.
The concentration of aldosterone in the most cases
achieves the high level. Has been mentioned the certain
correlation with the rennin containing.
According to our data, the character of the changes of
above mentioned hormone levels is much important as
longer is the duration of the diabetes and doesn't
depend on time passed from onset of nephropathy.
The role of the patient's age has not appeared to be in
strong correlation with the levels of hormones. As for
AKTH changes the correlation with aldosterone levels in
our results has not been observed as well
References
1.
Bedd A, Camerini-Davelos R. Diabetes nephropathy. An update Arch internal med. 1990; 150(1):31-43.
2.
Bell D. Hypertension in the person with diabetes. Amer J med Sci. 1989; 297:4: 228-232.
3.
Noth R, Krolesk A, Kaysen G, et al. Diabetic nephropathy Hemodinamic basis and implications for disease
management. Ann intern med. 1989; 110(10):795-813.
4.
Murabayashi D, Baba T, Tomypima T, et al. Urinary dopamine noradreneline and adrenaline in type 2 diabetic
patients with and without nephropathy. Hormone metabol Res. 1989; 21(1):27-32.
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