Download Powerpoint - Blood Journal

Extracellular RNA mediates endothelial-cell permeability
via vascular endothelial growth factor
by Silvia Fischer, Tibo Gerriets, Carina Wessels, Maureen Walberer, Sawa Kostin,
Erwin Stolz, Kirila Zheleva, Andreas Hocke, Stefan Hippenstiel, and Klaus T.
Preissner
Blood
Volume 110(7):2457-2465
October 1, 2007
©2007 by American Society of Hematology
Induction of endothelial-cell permeability by extracellular nucleic acids.
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Disintegration of endothelial monolayers mediated by extracellular nucleic acids.
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Induction of endothelial-cell permeability by RNA is mediated via VEGF. Confluent BMEC
cultures were preincubated for 2 days with (A) antisense oligonucleotide to VEGF-R2 (as-VEGFR2; 2 μM) or the scrambled nonsense oligonucleotide (scr-VEGF-R2; 2 μM).
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Direct binding of RNA to VEGF. (A) Binding of biotinylated RNA to immobilized VEGF165,
VEGF121, platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), or
placenta-derived growth factor (PlGF-1) was performed in a solid binding assay, ...
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Influence of RNase pretreatment on venous thrombosis in rats.
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Influence of RNase on brain edema in a stroke model in rats.
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology
Influence of RNase on vessel integrity in infarcted brain tissue.
Silvia Fischer et al. Blood 2007;110:2457-2465
©2007 by American Society of Hematology