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Regulation and function of AMPK. Proteins that are directly phosphorylated by AMPK are shown in bold font. The blue arrows indicate stimulation, and the
red lines indicate inhibition. Processes activated by AMPK are labeled in blue, while the processes inhibited by AMPK are shown in red. (ACC, acetyl-CoA
carboxylase; AKT, AKR mouse tumor 8 kinase; CamKK, calcium/calmodulin-dependent protein kinase kinase; eEF2, eukaryotic translation elongation
factor 2; FAS, fatty acid synthase; G6P, glucose-6-phosphatase; GPAT, glycerol-3-phosphate acyltransferase, mitochondrial; HK, hexokinase; HMGR,
HMG-CoA reductase; LKB1, liver kinase B1; MCD, malonyl-CoA decarboxylase; mTOR, mammalian target of rapamycin; PEPCK, phosphoenolpyruvate
carboxykinase; PFK2, 6-phosphofructo-2-kinase/fructose-2,6–bisphosphatase; PGC1α, peroxisome proliferator-activated receptor gamma coactivator-1;
Source: Chapter 17. Pancreatic Hormones and Diabetes Mellitus, Greenspan’s Basic & Clinical Endocrinology, 9e
PKA, protein kinase A; PP2C, protein phosphatase 2C; SREBP1c, sterol regulatory element–binding protein 1c; Tak1, TGF-beta-activated kinase 1;
Gardner
DG, Shoback
D. Greenspan’s
Basic
& Clinicaltuberous
Endocrinology,
9e;1).2011 Available at: http://mhmedical.com/ Accessed: August
transducer ofCitation:
regulated
cAMP response
element-binding
protein
2; TSC1/2,
sclerosis
03, 2017
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