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Genetic variants in ADAMTS13 as well as smoking are
major determinants of plasma ADAMTS13 levels
by Qianyi Ma, Paula M. Jacobi, Brian T. Emmer, Colin A. Kretz, Ayse Bilge Ozel,
Beth McGee, Chava Kimchi-Sarfaty, David Ginsburg, Jun Z. Li, and Karl C. Desch
BloodAdv
Volume 1(15):1037-1046
June 27, 2017
©2017 by American Society of Hematology
Qianyi Ma et al. Blood Adv 2017;1:1037-1046
©2017 by American Society of Hematology
Meta-analysis of ADAMTS13 levels in GABC and TSS. (A) Genome-wide plot of –log10(P) for
∼5.82 million SNPs. The red line marks the 5.0E-8 threshold of genome-wide significance.
Qianyi Ma et al. Blood Adv 2017;1:1037-1046
©2017 by American Society of Hematology
Functional tests of ADAMTS13 variant expression secretion and activity.
Qianyi Ma et al. Blood Adv 2017;1:1037-1046
©2017 by American Society of Hematology
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