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Dr. Milena Romanello, PhD
Education
Jul 1984: General Certificate of Education "Liceo Scientifico G. Marinelli" – Udine (UD), Italy.
Jul 1991: M.Sc. in Chemistry and Biopharmaceutical Technologies, University of Trieste, Italy.
Evaluation: 110/110 cum laude.
Nov 1996: PhD in Biochemistry, University of Trieste, Italy.
Professional Experience
Jun 1989 – Jun 1991: Undergraduate trainee in Biochemistry, Department of Biochemistry,
Biophysics and Macromolecular Chemistry (BBCM),University of Trieste,
Italy.
Oct 1991 – Oct 1995: Pre-doctoral Fellow in Biochemistry, University of Trieste, Italy.
Nov 1995 –Nov 1996: Research fellow in Clinical Biochemistry, University of Trieste, Italy.
Dec 1996 - Dec 1998: Post-doctoral fellow in Biochemistry,University of Trieste, Italy.
Jan 1999 – Jan 2004: Research Assistant in Research Groups of Prof. L. Moro, MD, and P.
D’Andrea, Ph.D., Department of Biochemistry, Biophysics and
Macromolecular Chemistry,University of Trieste, Italy.
Feb 2004 – Feb 2011: Research Assistant in Molecular Biology Research Group of Prof. Gianluca
Tell, PhD, Department of Biomedical Sciences and Technologies, University
of Udine, Italy.
March 2011–actually: Research Assistant at the Laboratory of Regional Centre for Rare Diseases
University
Hospital
"Santa
Maria
della
Misericordia"
33100 Udine, Italy.
Actually she is attending to biochemical assays useful to the laboratory diagnosis of
lysosomal rare diseases. Notably, she is improving a method in tandem-mass
spectrometry for the determination of biochemical markers of Niemann-Pick C disease.
Publications
She authored 46 publications in international peer reviewed journals.
Last Publications:
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Malini E, Zampieri S, Deganuto M, Sechi A, Romanello M, Bembi B, Dardis A. Role of
LIMP-2 in the intracellular trafficking of beta glucosidase in different human cellular
models. Submitted to Traffic
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Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli
G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP. The
redox function of APE1 is involved in the differentiation process of stem cells toward a
neuronal cell fate. Plos One (2014), 9(2) e89232.
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Dardis A, Zanin I, Zampieri S, Stuani C, Pianta A, Romanello M, Baralle FE, Bembi B,
Buratti E. Functional characterization of the common c.-32-13T>G mutation of GAA gene:
identification . of potential therapeutic agents. Nucleic Acids Research (2014), 42(2): 12911302.
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Romanello M, Piatkowska E, Antoniali G, Cesaratto L, Vascotto C, Iozzo RV, Delneri D,
Brancia FL. Osteoblastic cell secretome: A novel role for progranulin during risedronate
treatment. Bone (2013), 58: 81-91.
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Lirussi L, Antoniali G, Vascotto C, D’Ambrosio C, Poletto M, Romanello M, Marasco D,
Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, and Gianluca Tell. Nucleolar
accumulation of APE1 depends on charged lysine residues that undergo acetylation upon
genotoxic stress and modulate its BER activity in cells. Molecular Biology of the cell (2012),
23: 4079-4096.
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Bivi N, Lezcano V, Romanello M, Bellido T, and Plotkin LI. Connexin43 interacts with βarrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. J Cell
Biochem (2011), 112(10):2920-30.
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Bivi N, Picotti P, Mueller LN, Romanello M, Moro L, Quadrifoglio F, and Tell G. Shotgun
Proteomics Analysis Reveals New Unsuspected Molecular Effectors of Nitrogen-Containing
Bisphosphonates in Osteocytes. J Proteomics (2011), 74(7): 1113-22.
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Pianta A, Puppin C, Passon B, Franzoni A, Romanello M, Tell G, Di Loreto C, Bulotta S,
Russo D, Damante G. Nucleophosmin delocalization in thyroid tumour cells. Endocr Pathol
(2011), 22(1):18-23.
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Fantini D, Vascotto C, Marasco D, D’Ambrosio C, Romanello M, Vitagliano L, Pedone C,
Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, and Tell G. Critical lysine
residues within the overlooked N-terminal domain of human Ape1 regulates its biological
functions. Nucleic Acids Research (2010), 38(22): 8239-56.
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Pianta A, Fabbro D, Damiani D, Tiribelli M, Fanin R, Franzoni A, Romanello M, Tell G, Di
Loreto C, and Damante G. Two novel NPM1 mutations in a therapy-responder AML patient.
Hematol Oncol (2010), 28(3):151-5.
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Pianta A, Fabbro D, Damiani D, Tiribelli M, Fanin R, Franzoni A, Romanello M, Tell G,
and Damante G. Unexpected phenotype from a typical NPM1 mutant. Br J Haematol
(2009) 147:760-3.
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Bivi N, Romanello M, Harrison R, Clarke I, Hoyle DC, Moro L, Ortolani F, Bonetti A,
Quadrifoglio F, Tell G and Delneri D. Identification and characterization of new secondary
targets of nitrogen-containing bisphosphonates in mammalian cells via parallel competition
analysis of the barcoded yeast deletion collection. Genome Biol (2009) 10:R93.
Scientific Meeting Attendance
She has attended with Posters and Oral presentations to about sixty national and international
Scientific Meetings.
Teaching experiences
Oct 1996 - Feb 2000: Teaching assistant to Prof. L. Moro, M.D., Biochemistry Course, Master in
Pharmaceutical Sciences, University of Trieste, Italy.
Oct 2000 - 2004:
Lecturer in Chemistry, Master in Nursing Practice, University of Trieste,
Italy.
June 16, 2014:
National scientific qualification to function as associate professor in
Biochemistry (05/E1) in Italian Universities.
From Oct 2014:
Lecturer in Chemistry and Propaedeutic Biochemistry, Master in Sports
Sciences, University of Udine, Italy.