Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Download Table Ia. Genes whose basal expression is down-regulated in IRF
Document related concepts
no text concepts found
Transcript
Table Ia. Genes whose basal expression is down-regulated in IRF-2-/- mice when compared to IRF-2+/+ mice Function1 Multidrug resistance protein Accession NM_011075 Ratio2 6.49 Cytoskeletal network NM_009609 NM_007393 NM_013798 NM_183194 NM_177912 NM_011921 NM_013467 NM_011921 NM_013467 NM_009656 9.86 1 Symbol ABCB1B 2 ACTB Title ATP-binding cassette, subfamily B (MDR/TAP), member 1B Actin, beta, cytoplasmic 3 AI987692 Expressed sequence AI987692 Unknown 4 ALDH1A1 Ethanol metabolism 5 ALDH1A7 6 ALDH2 7 8 9 APCS APOC4 ARF4 Aldehyde dehydrogenase family 1, subfamily A1 Aldehyde dehydrogenase family 1, subfamily A7 Aldehyde dehydrogenase 2, mitochondrial Serum amyloid P component Apolipoprotein C-IV ADP-ribosylation factor 4 10 11 12 ASGR1 BTF3 CALM1 Asialoglycoprotein receptor 1 Basic transcription factor 3 Calmodulin 1 Endocytosis Transcription factor Enzyme control 13 CALR Calreticulin 14 CFH 15 CIDEB 16 CML2 Complement component factor H Cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Camello-like 2 Chaperone regulation of calcium homeostasis Complement cascade activation Apoptosis 17 CRISP2 18 19 20 CSNK2B CTSL CYP2D10 21 D6UCLA1E (adipor2) 22 DNAJC12 23 24 F2 GA17 Cysteine-rich secretory protein 2 Casein kinase II, beta subunit Cathepsin L Cytochrome P450, family 2, subfamily D, polypeptide 10 DNA segment, chr 6, University of California at Los Angeles-1, expressed DnaJ, (Hsp40) homolog, subfamily C, member 12 Coagulation factor II Dendritic cell protein GA17 Ethanol metabolism Ethanol metabolism Unknown Lipoprotein metabolism Signal transduction 7.11 8.56 12.66 11.6 NM_011318 NM_007385 NM_007480 NM_007479 NM_009714 NM_145455 NM_007589 NM_007590 NM_009790 NM_007591 37.05 12.81 9.36 NM_009888 8.38 NM_009894 19.5 N-acetyltransferase Cell adhesion Cell adhesion NM_053096 25.83 NM_009420 6.74 Signal transduction Protease Oxidase NM_009975 NM_009984 NM_010005 9.83 11.83 20.94 Protein binding Lipid metabolism NM_197985 9.35 Protein folding NM_013888 9.75 Coagulation cascade Unknown NM_145380 19.8 6.82 18.29 10.74 12.08 27.47 25 GBP2 Guanylate nucleotide binding protein 2 Glutamate-ammonia ligase (glutamine synthase) Glucose phosphate isomerase 1 Glucose regulated protein Histocompatibility 2, D region locus 1 Histocompatibility 2, T region locus 22 H3 histone, family 3B GTPase Growth Glutamine metabolism NM_010260 10.8 26 GLUL NM_008131 6.43 27 28 29 GPI1 GRP58 H2-D1 Glycolisis Chaperone Presentation of antigens NM_008155 NM_007952 NM_010391 5.88 14.4 40.54 30 H2-T22 Presentation of antigens 13.08 3-hydroxy-3-methylglutarylCoenzyme A lyase Heat shock 70kD protein 5 (glucose-regulated protein) Inhibitor of DNA binding 2 Interleukin 1 receptor, type 1 Insulin induced gene 2 Lipid metabolism NM_010399 NM_010397 NM_008210 NM_008211 NM_000191 31 H3F3B 32 HMGCL 33 HSPA5 Chaperone NM_022310 14.17 34 35 36 IDB2 IL1R1 INSIG2 Differentiation inhibitor Signal transduction Differentiation Growth Unknown NM_010496 NM_008362 NM_178082 NM_133748 NM_018746 38.22 5.32 11.97 37 ITIH4 38 39 40 ITLN KHK LBP Pathogen recognition Carbohydrate metabolism Acute phase protein NM_010584 NM_008439 NM_008489 19.00 16.93 14.88 41 LCN2 Apoptosis Transport Neutrophil chemotactic Chondrocyte proliferation NM_008491 97.4 42 LECT2 43 44 LITAF LSM1 45 LY6E 46 MBD1 47 MUG1 Leukocyte cell-derived chemotaxin 2 LPS-induced TN factor LSM1 homolog, U6 small nuclear RNA associated Smlike protein Lymphocyte antigen 6 complex, locus E Methyl-CpG binding domain protein 1 Murinoglobulin 1 NM_010702 9.02 mRNA processing NM_019980 XM_357867 8.72 29.86 Differentiation NM_008529 39.45 Transcriptional repression NM_013594 13.58 Transport NM_008646 NM_008645 NM_008768 38.93 48 ORM1 Orosomucoid 1 49 ORM2 Orosomucoid 2 NM_011016 38.74 50 P4HB 51 52 PCBP1 PEMT 53 54 PON1 PPAP2B Prolyl 4-hydroxylase, beta polypeptide Poly(rC) binding protein 1 Phosphatidylethanolamine Nmethyltransferase Paraoxonase 1 Phosphatidic acid phosphatase type 2B NM_011032 50.16 Transcription activator Lipid metabolism NM_011865 NM_008819 10.14 10.01 Oxidative regulation Lipid metabolism NM_011134 NM_080555 10.62 6.49 Inter alpha trypsin inhibitor, heavy chain 4 Intelectin Ketohexokinase Lipopolysaccharide-binding protein Lipocalin 2 Nucleosome structure Acute phase plasma protein Transport Acute phase plasma protein Transport Protein metabolism 6.63 7.66 44.65 30.38 55 PSMB8 56 PSMD4 57 58 PSME1 PTP4A1 59 RNASE4 60 61 RPL18 S100A10 62 63 64 SEC61B SEC61G SEMA3D 65 SERPINA3N 66 SERPINF2 67 68 SH3GL1 SRPR 69 70 SSR4 SUI1-RS1 71 72 TXN1 UGT1A6 73 USP18 1 Proteasome subunit, beta type 8 (large multifunctional protease) Proteasome 26S subunit, nonATPase, 4 Proteasome 28S subunit, alpha Protein tyrosine phosphatase 4a1 Ribonuclease, RNase A family 4 Ribosomal protein L18 S100 calcium binding protein A10 (calpactin) Sec61, beta subunit Sec61, gamma subunit Sema domain, immunoglobulin domain (Ig), short basic domain, secreted Serine (or cysteine) proteinase inhibitor, clade A, member 3N Serine (or cysteine) proteinase inhibitor, clade F, member 2 SH3-domain GRB2-like 1 Signal recognition particle receptor Signal sequence receptor, delta Suppresor of initiator codon mutations, related sequence 1 (S. cerevisiae) Thioredoxin 1 UDP glycosyltransferase 1 family, polypeptide A6 Ubiquitin specific protease 18 NM_010724 8.45 Antigen processing NM_008951 10.04 Antigen processing Growth control NM_011189 NM_011200 11.88 7.44 Ribonuclease 17.01 Ribosomal protein Endocytosis NM_021472 NM_201239 NM_009077 NM_009112 Transport Transport Axon guidance NM_006808 NM_011343 NM_028882 7.17 10.91 19.04 Unknown NM_009252 25.00 Acute phase protein NM_008878 28.50 Synaptic vesicle recycling Transport NM_013664 NM_026130 10.24 8.52 Transport Protein biosynthesis NM_009279 NM_011508 9.23 11.45 Electron transport Bilirubin metabolism NM_011660 NM_145079 8.71 14.94 Protein catabolism NM_011909 9.52 Gene function is summarized from literature or data in LocusLink in NCBI (www.ncbi.nlm.nih.gov/LocusLink). 2 Antigen processing Normalized intensity ratio. 14.03 10.17 Table Ib. Genes whose expression is down-regulated in response to LPS in IRF-2-/- mice when compared to IRF-2+/+ mice 1 Symbol AASS Title Aminoadipate-semialdehyde synthase ATP-binding cassette, subfamily A, member 7 2 ABCA7 3 ADCK4 4 ALDH2 5 6 AL033314 AP3D 7 8 9 APCS APOC4 ARHGEF1 10 11 BC013667 CAPNS1 AarF domain containing kinase 4 Aldehyde dehydrogenase 2, mitochondrial p100 co-activator Adaptor-related protein complex 3, delta subunit Serum amyloid P component Apolipoprotein C-IV Rho guanine nucleotide exchange factor (GEF) 1 Protein FAM34A Calpain, small subunit 1 12 CCT7 Chaperonin subunit 7 13 14 CD1D1 CIDEB 15 CSAD 16 CYP2A4 17 18 D11ERTD70 7E D19Wsu162e 19 DHCR24 20 21 22 23 DUSP8 FKBP8 FURIN G2AN 24 25 26 27 GLRX1 GPX1 HDAC2 HNRPA1 28 ICAM1 CD1D1 antigen Cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Cysteine sulfinic acid decarboxylase Cytochrome P450, family 2, subfamily a, polypeptide 4 Hypothetical protein D11ERTD707E Hypothetical protein D19WSU162E 24-dehydrocholesterol reductase Dual specificity phosphatase 8 FK506 binding protein 8 Furin Alpha glucosidase 2, alpha neutral subunit Glutaredoxin 1 Glutathione peroxidase 1 Histone deacetylase 2 Heterogeneous nuclear ribonucleoprotein A1 Intercellular cell adhesion Function1 Lysine degradation Accession NM_013930 Ratio2 6.08 Unknown; possible implication in lipid homeostasis Unknown NM_013850 3.62 NM_133770 4.29 Ethanol metabolism NM_009656 4.42 Transcriptional coactivator Intracellular protein transport Unknown Lipoprotein metabolism Regulation of cell cycle NM_019776 NM_007460 4.00 5.81 NM_011318 NM_007385 NM_008488 4.07 6.33 3.63 Unknown Apoptosis Regulation of cell cycle Regulation of cell cycle Folding of proteins MHC class I-like molecule Apoptosis NM_172266 NM_009795 3.76 3.65 NM_007638 3.59 NM_007639 NM_009894 4.94 4.95 Taurine biosynthesis NM_144942 4.05 Metabolism of estradiol and testosterone Unknown NM_009997 8.97 NM_025918 3.73 Unknown NM_146099 4.06 Cholesterol biosynthesis NM_053272 5.79 Signal transduction Apoptosis Protease Biosynthesis of proteoglycans Apoptosis Apoptosis inhibition Chromatin structure Protein translation and processing Adhesion molecule NM_008748 NM_010223 NM_011046 NM_008060 4.10 3.85 4.56 3.90 NM_053108 NM_008160 NM_008229 NM_010447 5.59 6.26 4.97 3.86 NM_010493 3.59 29 IGFBP4 30 ITIH2 31 KRT2-8 32 LBP 33 LECT2 34 LRP1 35 NDRG2 36 37 38 NRP OGFR P4HB 39 PAPSS2 40 41 42 PIPOX PLEC1 PSAP 43 PSMD4 44 SERPINF2 45 SPARC 46 STAT3 47 TYKI 48 UGT1A6 49 WBSCR14 1 molecule Insulin-like growth factor binding protein 4 Inter alpha trypsin inhibitor, heavy chain 2 Keratin complex 2, basic, gene 8 Lipopolysaccharide-binding protein Leukocyte cell-derived chemotaxin 2 Low-density lipoprotein receptor-related protein 1 N-myc downstream regulated gene 2 Neuropilin Opioid growth factor receptor Prolyl 4-hydroxylase, beta polypeptide 3’-phosphoadenosine 5’phosphosulfate synthase 2 Pipecolic acid oxidase Plectin1 Prosaposin Proteasome 26S subunit, nonATPase, 4 Serine proteinase inhibitor, clase F, member 2 Secreted acidic cysteine rich glycoprotein Signal transducer and activator of transcription 3 Thymidilate kinase family LPSinducible member UDP glycosyltransferase 1 family, polypeptide A6 Williams-Beuren syndrome chromosome region 14 homolog NM_010517 5.87 NM_010582 7.50 Epidermal differentiation NM_031170 9.21 Acute phase protein NM_008489 4.68 Neutrophil chemotactic Chondrocyte proliferation Cell migration Tissue repair Unknown NM_010702 4.35 NM_008512 5.44 NM_013864 5.30 Angiogenesis Cell proliferation Protein metabolism NM_008737 NM_031373 NM_011032 5.66 3.91 4.66 Sulfate activation pathway NM_011864 5.37 Proline metabolism Cytoskeletal network Neurotrophic factor Apoptosis inhibition Proteasome NM_008952 NM_201389 NM_011179 5.08 5.26 4.40 NM_008951 4.14 Inhibitor of plasmin and trypsin Cell growth regulation NM_008878 5.12 NM_009242 3.67 Transcription factor NM_011486 5.06 Nucleotide biosynthesis NM_020557 4.7 Bilirubin metabolism NM_145079 5.77 Transcriptional repressor NM_021455 3.43 Gene function is summarized from literature or data in LocusLink in NCBI (www.ncbi.nlm.nih.gov/LocusLink). 2 Apoptosis Migration Proliferation Unknown Normalized intensity ratio.
Related documents