Download 5112-5121 June 15, 2007

Gossypin, a pentahydroxy glucosyl flavone, inhibits the
transforming growth factor beta-activated kinase-1mediated NF-κB activation pathway, leading to potentiation
of apoptosis, suppression of invasion, and abrogation of
osteoclastogenesis
by Ajaikumar B. Kunnumakkara, Asha S. Nair, Kwang Seok Ahn, Manoj K. Pandey,
Zhengfang Yi, Mingyao Liu, and Bharat B. Aggarwal
Blood
Volume 109(12):5112-5121
June 15, 2007
©2007 by American Society of Hematology
Gossypin inhibits both constitutive and inducible NF-κB activation.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin inhibits TNF-induced NF-κB activation, IκBα degradation, IκBα phosphorylation, IKK
activation, p65 nuclear translocation, and p65 phosphorylation.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin inhibited the TNF-induced expression of the NF-κB-dependent genes TNFR1, TRADD,
TRAF2, NIK, IKK-β, TAK-1, and TAB-1.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin inhibits TNF-induced expression of NF-κB–regulated gene products.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin potentiates the apoptotic effects of TNF and chemotherapeutic agents.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin inhibits TNF-induced invasion and RANKL-induced osteoclastogenesis.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology
Gossypin inhibits the VEGF-induced migration of human umbilical vein vascular endothelial
cells.
Ajaikumar B. Kunnumakkara et al. Blood 2007;109:51125121
©2007 by American Society of Hematology