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Transcript 
Eosinophil extracellular DNA trap cell death mediates lytic
release of free secretion-competent eosinophil granules in
humans
by Shigeharu Ueki, Rossana C. N. Melo, Ionita Ghiran, Lisa A. Spencer, Ann M.
Dvorak, and Peter F. Weller
Blood
Volume 121(11):2074-2083
March 14, 2013
©2013 by American Society of Hematology
Transmission electron micrographs of human tissue eosinophils from (A) allergic and (B)
hypereosinophilic patients.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
EETosis releases weblike chromatin structures from lytic cells.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
EETosis developing within 120 minutes in an NADPH oxidase-dependent manner.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
Intact granules and limited granule protein localization at extracellular DNA nets released
through EETosis-mediated cell lysis.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
Characteristics of EETosis-induced intact eosinophil granule release.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
Released granules were secretion competent in response to CCL11.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
EETosis induces the release of intact cell-free granules through budding and cell lysis.
Shigeharu Ueki et al. Blood 2013;121:2074-2083
©2013 by American Society of Hematology
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