Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Powerpoint - Blood Journal
Document related concepts
no text concepts found
Transcript
Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans by Shigeharu Ueki, Rossana C. N. Melo, Ionita Ghiran, Lisa A. Spencer, Ann M. Dvorak, and Peter F. Weller Blood Volume 121(11):2074-2083 March 14, 2013 ©2013 by American Society of Hematology Transmission electron micrographs of human tissue eosinophils from (A) allergic and (B) hypereosinophilic patients. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology EETosis releases weblike chromatin structures from lytic cells. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology EETosis developing within 120 minutes in an NADPH oxidase-dependent manner. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology Intact granules and limited granule protein localization at extracellular DNA nets released through EETosis-mediated cell lysis. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology Characteristics of EETosis-induced intact eosinophil granule release. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology Released granules were secretion competent in response to CCL11. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology EETosis induces the release of intact cell-free granules through budding and cell lysis. Shigeharu Ueki et al. Blood 2013;121:2074-2083 ©2013 by American Society of Hematology
Related documents