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COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1 by Akihiro Yoshida, Jun-ya Kato, Ikuko Nakamae, and Noriko Yoneda-Kato Blood Volume 122(10):1750-1760 September 5, 2013 ©2013 by American Society of Hematology Ectopic expression of COP1 in 32D cells induces degradation of C/EBPα and blocks granulocytic differentiation in response to G-CSF. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology Ligase activity-deficient COP1 mutants fail to induce degradation of C/EBPα and block granulocytic differentiation. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology Different ability of splicing variants of COP1 to induce degradation of C/EBPα and block granulocytic differentiation. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology Trib1 cooperates with COP1 to induce ubiquitination of C/EBPα and block granulocytic differentiation. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology Distribution of myeloid progenitor populations of transplanted BM cells at the early stage. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology COP1 cooperates with Trib1 to induce ACL. Mice were transplanted with BM cells infected with retroviral vectors containing MigR1 (GFP+) control, COP1 (GFP+), CSmut (GFP+), and Trib1 and examined several months after BMT. (A) Myeloid leukemia-free survival c... Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology COP1 cooperates with Trib1 to increase committed myeloid progenitors. Akihiro Yoshida et al. Blood 2013;122:1750-1760 ©2013 by American Society of Hematology
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