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Kaplan–Meier estimate for clinical worsening in idiopathic pulmonary fibrosis patients a) by matrix metalloproteinase-7 median cut-off level at baseline (B) and b) by the median MMP-7 cutoff level when both baseline and end-of-study (E) values are considered. Yasmina Bauer et al. ERJ Open Res 2017;3:00074-2016 ©2017 by European Respiratory Society