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Heterogeneity in Fanconi anemia: evidence for 2 new genetic subtypes by Marieke Levitus, Martin A. Rooimans, Jûrgen Steltenpool, Nicolle F. C. Cool, Anneke B. Oostra, Christopher G. Mathew, Maureen E. Hoatlin, Quinten Waisfisz, Fré Arwert, Johan P. de Winter, and Hans Joenje Blood Volume 103(7):2498-2503 April 1, 2004 ©2004 by American Society of Hematology FANCD2 mono-ubiquitination in FA-I and FA-J cells. Marieke Levitus et al. Blood 2004;103:2498-2503 ©2004 by American Society of Hematology Cell fusion results assigning 8 FA cell lines to 2 new complementation groups, I and J. Each box indicates a fusion experiment between 2 cell lines, for instance, the one on top of the vertical column and the one at the end of the horizontal row. Marieke Levitus et al. Blood 2004;103:2498-2503 ©2004 by American Society of Hematology Formation of FA protein core complex in FA-I and FA-J cells. Marieke Levitus et al. Blood 2004;103:2498-2503 ©2004 by American Society of Hematology Relative prevalences of 11 complementation groups in FA. Results are based on the first 241 FA families classified by the European Fanconi Anemia Research Programme (1994-2003). Marieke Levitus et al. Blood 2004;103:2498-2503 ©2004 by American Society of Hematology