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Electromechanical Dyssynchrony and Resynchronization
of the Failing Heart
by Jonathan A. Kirk, and David A. Kass
Circulation Research
Volume 113(6):765-776
August 30, 2013
Copyright © American Heart Association, Inc. All rights reserved.
X-ray of patient receiving cardiac resynchronization therapy.
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
Regional and global pathophysiology of cardiac dyssynchrony.
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
The relationship between immediate left ventricle (LV) resynchronization and reduction in LV
end-systolic volume at the 6-month follow-up from Bleeker et al.73 Although an acute response
to cardiac resynchronization therapy (CRT; >20% LV resynchronization) seems necessary for a
positive chronic response (>10% LV reverse remodeling), among these responders the
relationship between acute and chronic response is very poor (inset).
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
Dyssynchrony reduced baseline cellular function, which is restored by cardiac
resynchronization therapy (CRT).
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
β-Adrenergic pathways are reduced in dyssynchronous heart failure (HFdys) but restored via
regulators of G-protein signaling 2/3 (RGS2/3) signaling in cardiac resynchronization therapy
(CRT).
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
Effect of dyssynchrony and cardiac resynchronization on mitochondrial function and oxidation.
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
Summary of molecular alterations in dyssynchronous heart failure (HFdys) and cardiac
resynchronization therapy (CRT).
Jonathan A. Kirk, and David A. Kass Circ Res.
2013;113:765-776
Copyright © American Heart Association, Inc. All rights reserved.
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