Download DNA Replication - Duplin County Schools

Wednesday
March 22, 2017
I can:
Agenda
Catalyst

(10) Catalyst
(30) Alien Encounters!
(10) GN: Mutations
(15) Kahoot
(15) IP: Mutations
(5) Exit Ticket
explain how mutations affect
protein synthesis
1. What is nondisjunction?
2. How does this differ from a
mutation?
3. What is the polypeptide made
from the DNA sequence
TACCAAGTA?
HW: IP: Mutations
Mutations
A mutation is a change in a DNA sequence.
• Mutation leads to genetic VARIATION!
How does a
Types of Mutations
substitution affect
the overall amino
acid sequence?
Substitution – one base is swapped out for
another.
How does an
Types of Mutations
insertion affect the
overall amino acid
sequence?
Insertion – an extra base pair(s) is added into a
new place in the DNA
How does a deletion
Types of Mutations
affect the overall
amino acid
sequence?
Deletion – Base pairs in the sequence are lost or
deleted
Types of Mutations
Insertions and deletions are called frame shift
mutations.
• DNA is “read” in 3-base codons
• in/dels change the reading frame
ATGACGTAA
ATCGACGTAA
mutation!