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Supplemental Table 3. Previously defined 344 gene atherosclerosis gene signature Gene Symbol FCGR2A Gene Name Fc fragment of IgG, low affinity IIa, receptor (CD32) KCNJ2 STX3 TLR8 ACSL1 CLEC4E TLR8 TLR4 TM6SF1 CASP4 NAMPT FPRL1 LOC399744 QPCT MCL1 P2RY13 TNFSF14 IL1R2 TGFA LOC730820 ABLIM1 GK GPR97 VNN2 STX11 CA4 TLR2 MME FLJ20273 RAB24 TNFRSF10B IL1RN IL1B FAM126B TLR6 CPD MGAM ENTPD1 potassium inwardly-rectifying channel, subfamily J, member 2 syntaxin 3 toll-like receptor 8 acyl-CoA synthetase long-chain family member 1 C-type lectin domain family 4, member E toll-like receptor 8 toll-like receptor 4 transmembrane 6 superfamily member 1 caspase 4, apoptosis-related cysteine peptidase nicotinamide phosphoribosyltransferase formyl peptide receptor 2 hypothetical LOC399744 glutaminyl-peptide cyclotransferase myeloid cell leukemia sequence 1 (BCL2-related) purinergic receptor P2Y, G-protein coupled, 13 tumor necrosis factor (ligand) superfamily, member 14 interleukin 1 receptor, type II transforming growth factor, alpha NA actin binding LIM protein 1 glycerol kinase G protein-coupled receptor 97 vanin 2 syntaxin 11 carbonic anhydrase IV toll-like receptor 2 membrane metallo-endopeptidase RNA binding motif protein 47 RAB24, member RAS oncogene family tumor necrosis factor receptor superfamily, member 10b interleukin 1 receptor antagonist interleukin 1, beta family with sequence similarity 126, member B toll-like receptor 6 carboxypeptidase D maltase-glucoamylase (alpha-glucosidase) ectonucleoside triphosphate diphosphohydrolase 1 LRG1 NFIL3 FFAR2 SMARCD3 ROPN1L LAMP2 FAIM3 B4GALT5 MYBPC3 EIF4E3 CREB5 LIMK2 CSF2RB LILRA5 MAPK14 KCNJ15 STEAP4 NCF4 GNG10 PILRA SIRPB1 CDC25B FRAT1 RAB24 CEACAM3 NCF4 TLR1 CCDC64 MEFV MOSC1 SNAP23 WDFY3 GAB2 ABHD5 EGLN1 BEST1 PHC2 LOC339745 IL6R ZNF438 KBTBD7 leucine-rich alpha-2-glycoprotein 1 nuclear factor, interleukin 3 regulated free fatty acid receptor 2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 ropporin 1-like lysosomal-associated membrane protein 2 Fas apoptotic inhibitory molecule 3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 myosin binding protein C, cardiac eukaryotic translation initiation factor 4E family member 3 cAMP responsive element binding protein 5 LIM domain kinase 2 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 mitogen-activated protein kinase 14 potassium inwardly-rectifying channel, subfamily J, member 15 STEAP family member 4 neutrophil cytosolic factor 4, 40kDa guanine nucleotide binding protein (G protein), gamma 10 paired immunoglobin-like type 2 receptor alpha signal-regulatory protein beta 1 cell division cycle 25 homolog B (S. pombe) frequently rearranged in advanced T-cell lymphomas RAB24, member RAS oncogene family carcinoembryonic antigen-related cell adhesion molecule 3 neutrophil cytosolic factor 4, 40kDa toll-like receptor 1 coiled-coil domain containing 64 Mediterranean fever MOCO sulphurase C-terminal domain containing 1 synaptosomal-associated protein, 23kDa WD repeat and FYVE domain containing 3 GRB2-associated binding protein 2 abhydrolase domain containing 5 egl nine homolog 1 (C. elegans) bestrophin 1 polyhomeotic homolog 2 (Drosophila) speckle-type POZ protein-like interleukin 6 receptor zinc finger protein 438 kelch repeat and BTB (POZ) domain containing 7 FRAT1 PLXNC1 UBE2L6 NTNG2 CD27 RCN3 LOC729021 NAMPT SIPA1L2 FAM53C PIK3IP1 REM2 HCG27 GPR97 CLEC7A MAG1 MANSC1 EMR3 PELI1 MAP4K1 IL8RB CSF3R KIAA0125 DYSF CREB5 HK2 KLHL2 SELM ST8SIA4 LDLRAP1 IL1R2 PLAUR RAB11FIP1 ELL TSEN34 IDS OSM BTBD14A TIMP2 DKFZp761E 198 NCF1 MAPK14 frequently rearranged in advanced T-cell lymphomas plexin C1 ubiquitin-conjugating enzyme E2L 6 netrin G2 CD27 molecule reticulocalbin 3, EF-hand calcium binding domain hypothetical protein LOC729021 nicotinamide phosphoribosyltransferase signal-induced proliferation-associated 1 like 2 family with sequence similarity 53, member C phosphoinositide-3-kinase interacting protein 1 RAS (RAD and GEM)-like GTP binding 2 HLA complex group 27 G protein-coupled receptor 97 C-type lectin domain family 7, member A 1-acylglycerol-3-phosphate O-acyltransferase 9 MANSC domain containing 1 egf-like module containing, mucin-like, hormone receptor-like 3 pellino homolog 1 (Drosophila) mitogen-activated protein kinase kinase kinase kinase 1 interleukin 8 receptor, beta colony stimulating factor 3 receptor (granulocyte) KIAA0125 dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) cAMP responsive element binding protein 5 hexokinase 2 kelch-like 2, Mayven (Drosophila) selenoprotein M ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 low density lipoprotein receptor adaptor protein 1 interleukin 1 receptor, type II plasminogen activator, urokinase receptor RAB11 family interacting protein 1 (class I) elongation factor RNA polymerase II tRNA splicing endonuclease 34 homolog (S. cerevisiae) iduronate 2-sulfatase oncostatin M NACC family member 2, BEN and BTB (POZ) domain containing TIMP metallopeptidase inhibitor 2 DKFZp761E198 protein neutrophil cytosolic factor 1 mitogen-activated protein kinase 14 PLAUR MOSPD2 NPL DOCK5 IKIP ACOX1 HIATL1 ZDHHC18 PILRA KIAA0319L RNF122 CSF2RA IRAK3 IL8RA ST3GAL4 PTGS2 MAGED1 FAM113B ST6GALNA C2 USP32 TSHZ3 SLC22A4 C3orf62 C16orf57 KIAA0746 ATP6V0E2 TLR5 ABHD3 ADM HPCAL4 LST1 ST8SIA4 STAT3 DIRC2 NADK DUSP1 LAT2 TNFSF14 C14orf138 ANXA3 plasminogen activator, urokinase receptor motile sperm domain containing 2 N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) dedicator of cytokinesis 5 IKK interacting protein acyl-Coenzyme A oxidase 1, palmitoyl hippocampus abundant transcript-like 1 zinc finger, DHHC-type containing 18 paired immunoglobin-like type 2 receptor alpha KIAA0319-like ring finger protein 122 colony stimulating factor 2 receptor, alpha, low-affinity (granulocytemacrophage) interleukin-1 receptor-associated kinase 3 interleukin 8 receptor, alpha ST3 beta-galactoside alpha-2,3-sialyltransferase 4 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) melanoma antigen family D, 1 family with sequence similarity 113, member B ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-Nacetylgalactosaminide alpha-2,6-sialyltransferase 2 ubiquitin specific peptidase 32 teashirt zinc finger homeobox 3 solute carrier family 22 (organic cation/ergothioneine transporter), member 4 chromosome 3 open reading frame 62 chromosome 16 open reading frame 57 KIAA0746 protein ATPase, H+ transporting V0 subunit e2 toll-like receptor 5 abhydrolase domain containing 3 adrenomedullin hippocalcin like 4 leukocyte specific transcript 1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 signal transducer and activator of transcription 3 (acute-phase response factor) disrupted in renal carcinoma 2 NAD kinase dual specificity phosphatase 1 linker for activation of T cells family, member 2 tumor necrosis factor (ligand) superfamily, member 14 chromosome 14 open reading frame 138 annexin A3 PTPRCAP PLCG1 C20orf3 GPR109B C9orf72 DGKA DENND3 REPS2 PYGL PTAFR SKAP2 TMEM157 FAM102A LOC728014 MAK GPR109A CENTD3 BIN1 PLXDC2 PANX2 PSG3 E2F3 SIPA1L1 SLC43A2 MMP25 INADL SLCO3A1 IRS2 BCL11B RP2 EDG4 HSPA6 IL6R TREM1 CASP8 SEC14L1 GNAQ Rgr C10orf38 TCF4 TTC27 IBRDC2 EVA1 protein tyrosine phosphatase, receptor type, C-associated protein phospholipase C, gamma 1 chromosome 20 open reading frame 3 niacin receptor 2 chromosome 9 open reading frame 72 diacylglycerol kinase, alpha 80kDa DENN/MADD domain containing 3 RALBP1 associated Eps domain containing 2 phosphorylase, glycogen, liver platelet-activating factor receptor src kinase associated phosphoprotein 2 family with sequence similarity 174, member A family with sequence similarity 102, member A NA male germ cell-associated kinase niacin receptor 1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 bridging integrator 1 plexin domain containing 2 pannexin 2 pregnancy specific beta-1-glycoprotein 3 E2F transcription factor 3 signal-induced proliferation-associated 1 like 1 solute carrier family 43, member 2 matrix metallopeptidase 25 InaD-like (Drosophila) solute carrier organic anion transporter family, member 3A1 insulin receptor substrate 2 B-cell CLL/lymphoma 11B (zinc finger protein) retinitis pigmentosa 2 (X-linked recessive) lysophosphatidic acid receptor 2 heat shock 70kDa protein 6 (HSP70B') interleukin 6 receptor triggering receptor expressed on myeloid cells 1 caspase 8, apoptosis-related cysteine peptidase SEC14-like 1 (S. cerevisiae) guanine nucleotide binding protein (G protein), q polypeptide ral guanine nucleotide dissociation stimulator-like 4 family with sequence similarity 171, member A1 transcription factor 4 tetratricopeptide repeat domain 27 ring finger protein 144B myelin protein zero-like 2 SPTAN1 CRISPLD2 CXCL16 TMCC3 RAB20 COBLL1 CDR2 ECHDC2 SUSD3 GIMAP5 WSB1 VNN3 C9orf164 RAB11FIP1 DPEP3 BCAS4 AMD1 ITM2C GPR177 SASP SKAP1 CXXC5 GNAI3 LY9 RRAGD SLC9A8 CCR7 KLHL3 ARRDC3 C5AR1 FCGR3B CLIC1 ITPR3 MGC4093 C3orf34 ATG16L2 DKFZp434K 1815 CUEDC1 RASGRP3 PSTPIP2 PROK2 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) cysteine-rich secretory protein LCCL domain containing 2 chemokine (C-X-C motif) ligand 16 transmembrane and coiled-coil domain family 3 RAB20, member RAS oncogene family COBL-like 1 cerebellar degeneration-related protein 2, 62kDa enoyl Coenzyme A hydratase domain containing 2 sushi domain containing 3 GTPase, IMAP family member 5 WD repeat and SOCS box-containing 1 vanin 3 NA RAB11 family interacting protein 1 (class I) dipeptidase 3 breast carcinoma amplified sequence 4 adenosylmethionine decarboxylase 1 integral membrane protein 2C G protein-coupled receptor 177 aspartic peptidase, retroviral-like 1 src kinase associated phosphoprotein 1 CXXC finger 5 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 lymphocyte antigen 9 Ras-related GTP binding D solute carrier family 9 (sodium/hydrogen exchanger), member 8 chemokine (C-C motif) receptor 7 kelch-like 3 (Drosophila) arrestin domain containing 3 complement component 5a receptor 1 Fc fragment of IgG, low affinity IIIb, receptor (CD16b) chloride intracellular channel 1 inositol 1,4,5-triphosphate receptor, type 3 B9 protein domain 2 chromosome 3 open reading frame 34 ATG16 autophagy related 16-like 2 (S. cerevisiae) leucine-rich repeats and WD repeat domain containing 1 CUE domain containing 1 RAS guanyl releasing protein 3 (calcium and DAG-regulated) proline-serine-threonine phosphatase interacting protein 2 prokineticin 2 PADI4 ZNF467 LOC340527 ARID3A SMPDL3A DUSP6 BLR1 C9orf45 STXBP5 C5orf32 FCER2 PKN2 F5 MAN2C1 HSDL2 DOCK10 ITK ZAP70 RNF141 ID3 NOTCH1 AFF3 TIMP2 DSC2 GBP2 WWC3 ALPL CD79A TMEM127 C11orf75 CYP4F3 NLRP12 ADARB1 ERGIC1 PARP9 CD6 PXN CEACAM1 PISD C13orf15 LOC728776 USP15 PGLYRP1 peptidyl arginine deiminase, type IV zinc finger protein 467 NHS-like 2 AT rich interactive domain 3A (BRIGHT-like) sphingomyelin phosphodiesterase, acid-like 3A dual specificity phosphatase 6 chemokine (C-X-C motif) receptor 5 NA syntaxin binding protein 5 (tomosyn) chromosome 5 open reading frame 32 Fc fragment of IgE, low affinity II, receptor for (CD23) protein kinase N2 coagulation factor V (proaccelerin, labile factor) mannosidase, alpha, class 2C, member 1 hydroxysteroid dehydrogenase like 2 dedicator of cytokinesis 10 IL2-inducible T-cell kinase zeta-chain (TCR) associated protein kinase 70kDa ring finger protein 141 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein Notch homolog 1, translocation-associated (Drosophila) AF4/FMR2 family, member 3 TIMP metallopeptidase inhibitor 2 desmocollin 2 guanylate binding protein 2, interferon-inducible WWC family member 3 alkaline phosphatase, liver/bone/kidney CD79a molecule, immunoglobulin-associated alpha transmembrane protein 127 chromosome 11 open reading frame 75 cytochrome P450, family 4, subfamily F, polypeptide 3 NLR family, pyrin domain containing 12 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 poly (ADP-ribose) polymerase family, member 9 CD6 molecule paxillin carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) phosphatidylserine decarboxylase chromosome 13 open reading frame 15 high-mobility group nucleosome binding domain 1 pseudogene ubiquitin specific peptidase 15 peptidoglycan recognition protein 1 BLK RPS8 CDCA7L VPREB3 CASP8 TNFAIP2 DHX34 USP10 LOC201175 S100A12 TLE3 ZNF101 LEF1 OAZ2 BCL2 CD302 CD79A HOOK1 PGAM1 PDE7A ST3GAL6 PGD SOD2 PACSIN1 FOS PTPRC ZNF121 OKL38 TREML2 PIK3AP1 CD3E C16orf7 EPHX2 BCL11A FBXL13 CDA UBN1 PPAPDC1B S100P HIST1H2AC BIRC3 HSD17B11 LPPR2 B lymphoid tyrosine kinase ribosomal protein S8 cell division cycle associated 7-like pre-B lymphocyte 3 caspase 8, apoptosis-related cysteine peptidase tumor necrosis factor, alpha-induced protein 2 DEAH (Asp-Glu-Ala-His) box polypeptide 34 ubiquitin specific peptidase 10 SH3 domain containing 20 S100 calcium binding protein A12 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) zinc finger protein 101 lymphoid enhancer-binding factor 1 ornithine decarboxylase antizyme 2 B-cell CLL/lymphoma 2 CD302 molecule CD79a molecule, immunoglobulin-associated alpha hook homolog 1 (Drosophila) phosphoglycerate mutase 1 (brain) phosphodiesterase 7A ST3 beta-galactoside alpha-2,3-sialyltransferase 6 phosphogluconate dehydrogenase superoxide dismutase 2, mitochondrial protein kinase C and casein kinase substrate in neurons 1 FBJ murine osteosarcoma viral oncogene homolog protein tyrosine phosphatase, receptor type, C zinc finger protein 121 oxidative stress induced growth inhibitor 1 triggering receptor expressed on myeloid cells-like 2 phosphoinositide-3-kinase adaptor protein 1 CD3e molecule, epsilon (CD3-TCR complex) chromosome 16 open reading frame 7 epoxide hydrolase 2, cytoplasmic B-cell CLL/lymphoma 11A (zinc finger protein) F-box and leucine-rich repeat protein 13 cytidine deaminase ubinuclein 1 phosphatidic acid phosphatase type 2 domain containing 1B S100 calcium binding protein P histone cluster 1, H2ac baculoviral IAP repeat-containing 3 hydroxysteroid (17-beta) dehydrogenase 11 lipid phosphate phosphatase-related protein type 2 KIAA0319L SRPK1 LHFPL2 BST1 RNF24 CFP RPS5 SLC19A1 GBP1 ALDH16A1 FKBP1A CD93 SESN1 KIAA0319-like SFRS protein kinase 1 lipoma HMGIC fusion partner-like 2 bone marrow stromal cell antigen 1 ring finger protein 24 complement factor properdin ribosomal protein S5 solute carrier family 19 (folate transporter), member 1 guanylate binding protein 1, interferon-inducible, 67kDa aldehyde dehydrogenase 16 family, member A1 FK506 binding protein 1A, 12kDa CD93 molecule sestrin 1