Download Developmental Biology

Developmental Biology
BIO-233
Instructor:
Dr. Shahzad A. Mufti
Advisor Department of Biosciences
Course Contents
Introduction: Asexual and Sexual
reproduction. History of embryology.
Gametogenesis: Oogenesis and
Spermatogenesis. Molecular events during
Oogenesis, Nuclear and Cytoplasmic
events, Spermatogenesis and
Spermiogenesis.
Fertilization: External and Internal, Egg and
Sperm recognition , Activation of Gamete
metabolism, Fusion of Genetic material.
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Course Contents
Early development: Cleavage: patterns and
control. Gastrulation: Morphogenetic
movement of cells and cellular
rearrangements in amphibian, Fate maps.
Early development in birds. Early
developments in mammals (Humans).
Formation of Embryonic axis, Functions of
the Organizer and Mechanism of Induction.
Regional Specificity of Induction.
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Course Contents
A breif description of organogenesis in
vertebrates.
Metamorphosis in Amphibia. Regeneration:
Epimorphosis in Urodeles.
Aging: the Biology of Senescence.
 Medical implications of Developmental
biology, Teratogenesis: Genetic and
Environmental causes.
Cloning, Gene therapy and Stem cell
research.
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Text / Reference Books
Developmental Biology, by Scott F. Gillbert.
8th Ed. (2006). Sinauer Associates, Inc.
Massachusetts.
Analysis of Biological Development, by
Klaus Kalthoff. 2nd Ed. (2001) McGraw Hill,
New York.
Principles of Developmental Biology, by
Fred H. Wilt and Sarah Hake (2004) W. W.
Norton &Co., New York, London.
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Marks Distribution
First Sessional = 10%
Quiz-1 = 7%
Second Sessional = 15%
Quiz-2 = 8%
Lab = 10%
Final = 50%
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Introduction
Reproduction: One of three “Basic” instincts
Asexual and Sexual Reproduction.
Scope of study.
Phases of development: ontogenetic cycle.
History of Developmental Biology:
Aristotle’s (350 BC) times to Harvey’s time
(1651); studies on chick embryo.
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Introduction
Theories of Preformation (Bonnet, 1764)
and Epigenesis (Wolff, 1767).
Von Baer’s work (1828). First book’ Baer’s
Law: Ontogeny recapitulates phylogeny’.
“Biogenetic Law” of Muller-Haeckle (1868)
Discovery of Cell; demise of preformation.
The new interpretation of “Preformation
and Epigenesis”.
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“Developmental Biology is one of the
fastest growing and most exciting field in
biology, creating a framework that
integrates molecular biology, physiology,
cell biology, genetics, anatomy, cancer
research, neurobiology, immunology,
ecology and evolutionary biology. The
study of development has become
essential for understanding any other area
of biology”.*
* S. F. Gilbert, Developmental Biology, Page 4.
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