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Effect of antioxidant vitamins A, C, E and their analogues on azo-dye
binding protein in liver of rats treated with p-dimethylaminoazobenzene
By:Velanganni, AAJ (Velanganni, A. Antony Joseph)[ 1 ] ; Balasundaram, C (Balasundaram, C.)[ 2 ]
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
Volume: 48
Issue: 4
Pages: 373-377
Published: APR 2010
View Journal Information
Abstract
p-Dimethylaminoazobenzene (DAB) is an azo-dye and known to cause liver tumour in rats. Azo-dye binding protein is a
specific cytosolic protein involved in the translocation of azo-dye carcinogen metabolites from liver cytoplasm into the
nucleus. Administration of vitamin A (40,000) and 50,000 IU), L-ascorbic acid (500 and 1,000 mg) and vitamin E
succinate (200-500 mg) reduced the amount of azo-dye binding protein in liver of rats treated with DAB.
Supplementation of high doses of vitamin A acetate, vitamin A palmitate, sodium ascorbate, ascorbyl palmitate and
vitamin E acetate had no effect on the quantity of azo-dye binding protein in liver. When the vitamin mixture was given,
the level of azo-dye binding protein decreased in the liver at all the studied doses, which may be due to their synergistic
effect.
Keywords
Author Keywords:Antioxidant vitamins A, C and E; Azo-dye binding protein; p-Dimethylaminoazobenzene
KeyWords Plus:CARCINOGEN; METABOLITES; CULTURE; CELLS
Author Information
Reprint Address: Velanganni, AAJ (reprint author)
JJ Coll Arts & Sci, Dept Biochem, Pudukkottai 622422, India.
Addresses:
[ 1 ] JJ Coll Arts & Sci, Dept Biochem, Pudukkottai 622422, India
[ 2 ] Bharathidasan Univ, Dept Anim Sci, Tiruchchirappalli 620024, India
E-mail Addresses:[email protected]
Publisher
NATL INST SCIENCE COMMUNICATION-NISCAIR, DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110
012, INDIA
Categories / Classification
Research Areas:Life Sciences & Biomedicine - Other Topics
Web of Science Categories:Biology
Document Information
Document Type:Article
Language:English
Accession Number: WOS:000276485200005
PubMed ID: 20726335
ISSN: 0019-5189
Other Information
IDS Number: 580XW
Cited References in Web of Science Core Collection: 24
Times Cited in Web of Science Core Collection: 1
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