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Title: Prognostic prediction models for colorectal cancer patients after curative resection Norikatsu Miyoshi, M.D., Ph.D. 1*, Masayuki Ohue, M.D., Ph.D. 1*, Shingo Noura, M.D., Ph.D. 1 , Masayoshi Yasui, M.D., Ph.D1*, Keijiro Sugimura, M.D., Ph.D. 1, Akira Tomokuni, M.D., Ph.D. 1, Hirofumi Akita, M.D., Ph.D. 1, Shogo Kobayashi, M.D., Ph.D. 1,Hidenori Takahashi, M.D., Ph.D. 1, Takeshi Omori, M.D., Ph.D. 1, Yoshiyuki Fujiwara, M.D., Ph.D. 1, Masahiko Yano, M.D., Ph.D. 1 1 Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, JAPAN * These authors contributed equally. Corresponding author: Norikatsu Miyoshi, M.D., Ph.D. Department of Surgery Osaka Medical Center for Cancer and Cardiovascular Diseases 1−3−3 Nakamichi, Higashinari-ku, Osaka 537-8511, Japan Tel: +81-6-6972-1181, fax: +81-6-6981-8055, e-mail: [email protected] Author Contributions: N.M. and M.O. collected data; N.M., M.O., S.N., M.Y., T.S., K.S., H.A., K.G., S.K., H.T., T.O., Y.F., and M.Y. provided materials; N.M. and M.O. designed the study and analyzed data; N.M. wrote the paper. All authors discussed the results and commented on the manuscript. Short title: Prognostic prediction models for CRC Keywords: Prediction tool, colorectal cancer, metastasis, survival Competing interests The authors declare that no competing financial interests exist. The manuscript contains 2136 words (excluding references), 4 figures and 5 tables. Acknowledgements We would like to thank Y. Katayama for special technical assistance. Financial relationships This word was supported in part by grants from the Uehara Foundation and Takeda Science. 1