Download Comprehensive Molecular Analysis of Pediatric Thalamic Tumors

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project

page
1
page
2
page
3
page
4
page
5
page
6
page
7
page
8
page
9
Document related concepts
no text concepts found
Transcript 
016 - Comprehensive Molecular
Analysis of Pediatric Thalamic
Tumors
Javad Nazarian
Children’s National Medical Center
Histological Map of Tumor extension in DIPGs
Tumor extension in DIPGs
Nikbakht, Panditharatna, Mikael et al 2015
Genomic Map of Tumor extension
in Thalamic Glioma
Methylation
Genomic data of DIPGs with tumor
extension
Data generated
In progress
WGS
Midline Gliomas: Thalamic Tumors
Thalamic Glioma Specimen
Midline Glioma Project Overview
Histological
Staining
Proteomics
•
Post-mortem
•
Biopsy
Live
(biopsy)
•
Normal brains
Frozen tissue
or
FFPE tissue
DNA/RNA
CSF
Liquid
Biopsy
Plasma
WGS / WES
Methylation
RNA seq
Midline Gliomas
Tumor Migration in & out of Thalamus
Patient Cohort
36%
64%
Primary Thalamic Gliomas
Midline Gliomas with thalamic involvement
Related documents