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Human CD1c+ dendritic cells secrete high levels of IL-12
and potently prime cytotoxic T-cell responses
by Giulia Nizzoli, Jana Krietsch, Anja Weick, Svenja Steinfelder, Federica Facciotti,
Paola Gruarin, Annalisa Bianco, Bodo Steckel, Monica Moro, Mariacristina Crosti,
Chiara Romagnani, Katharina Stölzel, Sara Torretta, Lorenzo Pignataro, Carmen
Scheibenbogen, Petra Neddermann, Raffaele De Francesco, Sergio Abrignani, and
Jens Geginat
Blood
Volume 122(6):932-942
August 8, 2013
©2013 by American Society of Hematology
Frequency and proliferation of human DC subsets in bone marrow, peripheral blood, and tonsils.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
Surface receptor expression on DC subsets in different tissues.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
Regulation of IL-12 production by mDC1.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
mDC2 secrete high amounts of IFN-λ.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
Efficient antigen cross-presentation by TLR-stimulated mDC.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
TLR stimulation and CD4 help license DC to prime CD8+ T cells.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
Efficient and IL-12–dependent CTL generation by mDC1.
Giulia Nizzoli et al. Blood 2013;122:932-942
©2013 by American Society of Hematology
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