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Table S2. Enrichment of functional categories (DAVID analysis) within clusters of genes with membership in one of the following categories: plastic, not evolved (Fig. 1a); evolved, not plastic (Fig. 1b); plastic and evolved, same direiction (Fig. 1c); plastic and evolved, opposite direction (Fig. 1d). Categories are either from GO, INTERPRO, or Uniprot keyword searches, ‘count’ indicates the number of transcripts represented on the array, and ‘FDR’ is the Benjamini and Hochberg false discovery rate. Pattern Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1a Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1b Fig. 1c Enriched Term GO:0012505 endomembrane system (up) GO:0046907 intracellular transport (up) GO:0034613 cellular protein localization (up) GO:0005798 golgi-associated vesicle (up) Uniprot_Keyword: glycosyltransferase (up) Uniprot_Keyword: proteasome (up) Uniprot_Keyword: isomerase (up) GO:0007010 cytoskeleton organization (down) GO:0016028 rhabdomere (down) Uniprot_Keyword: nucleotide binding (down) GO:0007268 synaptic transmission (down) GO:0060284 regulation of cell development (down) Uniprot_Keyword: monooxygenase (up) GO:0000166 nucleotide binding (down) GO:0043233 organelle lumen (down) GO:0034660 ncRNA metabolic process (down) GO:0005739 mitochondrion (down) GO:0042254 ribosome biogenesis (down) GO:0006732 coenzyme metabolic processes GO:0065003 macromolecular complex assembly (down) GO:0006259 DNA metabolic processes (down) GO:0006457 protein folding (down) GO:0000278 mitotic cell cycle (down) GO:0008610 lipid biosynthetic processes GO:0006733 oxidoreduction coenzyme metabolic process (down) Uniprot_Keyword: methyltransferase (down) Uniprot_Keyword: monooxygenase (up,up) Count FDR 36 31 20 8 17 9 11 43 10 51 20 17 21 149 86 33 86 19 20 1.7E-8 1.3E-3 5.9E-3 1.4E-3 8.3E-3 7.6E-3 2.9E-2 1.3E-3 2.7E-4 1.7E-2 2.9E-2 1.5E-2 1.3E-3 1.2E-10 1.2E-7 6.6E-8 2.4E-7 3.4E-5 5.5E-4 34 34 18 41 19 4.4E-3 8.0E-4 4.6E-2 2.5E-2 2.9E-2 8 14 6 1.7E-2 3.0E-2 2.5E-2