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Laboratory Profile
Principal Investigator:
Liran Carmel
Computational biology, bioinformatics and molecular evolution
Location: Silberman building, 3rd. floor Room 2-342
Communication:
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E.Mail: [email protected]
Phone: 6585103
Web: http://carmelab.huji.ac.il
Brief description of research:
My lab is purely computational, and studies a wide
range of topics in comparative genomics and molecular evolution. We currently
focus on topics such as identifying noncoding functions of introns, identifying the
relations between introns in 3’UTRs and nonsense-mediated decay (NMD),
identifying disease-causing genetic variations, studying forces designing codon
usage bias in mammals, finding novel splicing regulatory elements, reconstructing
evolutionary histories, and understanding the Neanderthal genome.
Techniques: Computational biology and bioinformatics. We use many
computational techniques, depending on the specific question that we study. We
analyze a lot of deep sequencing data, including whole genome sequencing, whole
exome sequencing, and RNA-seq.
Proposed Research Projects:
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Topic 1: Studying whether intron jumping had been a major evolutionary force that can
explain peculiarities in intron-exon gene structure evolution.
Topic 2: Studying intron-related features of long noncoding RNAs (lncRNAs).