Download 157-166 June 8, 2016

Plasma Molecular Signatures in Hypertensive Patients With
Renin–Angiotensin System SuppressionNovelty and
Significance
by Montserrat Baldan-Martin, Laura Mourino-Alvarez, Laura Gonzalez-Calero, Rafael
Moreno-Luna, Tamara Sastre-Oliva, Gema Ruiz-Hurtado, Julian Segura, Juan
Antonio Lopez, Jesus Vazquez, Fernando Vivanco, Gloria Alvarez-Llamas, Luis M.
Ruilope, Fernando de la Cuesta, and Maria G. Barderas
Hypertension
Volume 68(1):157-166
June 8, 2016
Copyright © American Heart Association, Inc. All rights reserved.
A, Experimental design based on omics strategy to approach the unbiased, nontargeted study of
albuminuria in hypertensive patients searching for predictors and chronic organ damage
markers in blood plasma.
Montserrat Baldan-Martin et al. Hypertension. 2016;68:157166
Copyright © American Heart Association, Inc. All rights reserved.
A, Schematic picture of differentially expressed proteins identified by 2D-DIGE and iTRAQ and
those validated by selected reaction monitoring (SRM).
Montserrat Baldan-Martin et al. Hypertension. 2016;68:157166
Copyright © American Heart Association, Inc. All rights reserved.
Validation of 17 proteins by selected reaction monitoring (SRM).
Montserrat Baldan-Martin et al. Hypertension. 2016;68:157166
Copyright © American Heart Association, Inc. All rights reserved.
Receiver-operating characteristic (ROC) curves for classification of patients with de novo
albuminuria (dnA) and sustained albuminuria (SA) vs normoalbuminurics (N).
Montserrat Baldan-Martin et al. Hypertension. 2016;68:157166
Copyright © American Heart Association, Inc. All rights reserved.
The activation immune system in hypertensive patients with high albuminuria under chronic
renin–angiotensin system (RAS) suppression.
Montserrat Baldan-Martin et al. Hypertension. 2016;68:157166
Copyright © American Heart Association, Inc. All rights reserved.