Download Document

William M. Southerland Ph.D.
Affiliation:
Howard University
Biochemistry & Molecular Biology
"Informatics"
Title: Professor, Dept. Biochemistry & Molecular Biology
Rank: Professor,
Address:
520 W Street NW .Department of Biochemistry & Molecular Biology
Washington, DC 20059
Contact:
Email: [email protected]
Telephone: (202) 806-9711
Publications
1.
Ogindo CO, Khraiwesh MH, George M, Brandy Y, Brandy N, Gugssa A, Ashraf M, PubMed
Abbas M, Southerland WM, Lee CM, Bakare O, Fang Y. Novel drug design for Chagas
disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding
pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by
naphthoquinone derivatives. Bioorg Med Chem. 2016 Aug 15; 24(16):3849-55.
2.
Morris KF, Billiot EJ, Billiot FH, Hoffman CB, Gladis AA, Lipkowitz KB, Southerland PubMed
WM, Fang Y. Molecular Dynamics Simulation and NMR Investigation of the
Association of the ß-Blockers Atenolol and Propranolol with a Chiral Molecular
Micelle. Chem Phys. 2015 Aug 18; 457:133-146.
3.
Morris KF, Billiot EJ, Billiot FH, Gladis AA, Lipkowitz KB, Southerland WM, Fang Y. A PubMed
Molecular Dynamics Simulation Study of the Association of 1,1'-Binaphthyl-2,2'-diyl
hydrogenphosphate Enantiomers with a Chiral Molecular Micelle. Chem Phys. 2014
Aug 17; 439:36-43.
4.
Morris KF, Billiot EJ, Billiot FH, Lipkowitz KB, Southerland WM, Fang Y. A Molecular PubMed
Dynamics Simulation Study of Two Dipeptide Based Molecular Micelles: Effect of
Amino Acid Order. Open J Phys Chem. 2013 Feb 01; 3(1):20-29.
5.
Morris KF, Billiot EJ, Billiot FH, Lipkowitz KB, Southerland WM, Fang Y. Investigation PubMed
of Chiral Molecular Micelles by NMR Spectroscopy and Molecular Dynamics
Simulation. Open J Phys Chem. 2012 Nov 01; 2(4):240-251.
6.
Li H, Liu C, Burge L, Southerland W. Identification of two post-translational PubMed
modifications via tandem mass spectrometry. Int J Comput Biol Drug Des. 2012; 5(3-
4):314-24.
7.
Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, Zhou Y, Pang X, Southerland WM, Califano PubMed
JA, Gu X. Combination effects of salvianolic acid B with low-dose celecoxib on
inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo.
Cancer Prev Res (Phila). 2010 Jun; 3(6):787-96.
8.
Hu JZ, Bai L, Chen DG, Xu QT, Southerland WM. Computational investigation of the PubMed
anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Interdiscip Sci.
2010 Jun; 2(2):151-6.
9.
Chen P, Liu C, Burge L, Li J, Mohammad M, Southerland W, Gloster C, Wang B. PubMed
DomSVR: domain boundary prediction with support vector regression from sequence
information alone. Amino Acids. 2010 Aug; 39(3):713-26.
10. Fang YY, Morris VR, Lingani GM, Long EC, Southerland WM. Genome-Targeted Drug PubMed
Design: Understanding the Netropsin-DNA Interaction. Open Conf Proc J. 2010;
1:157-163.
11. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Prediction of inter- PubMed
residue contact clusters from hydrophobic cores. Int J Data Min Bioinform. 2010;
4(6):722-34.
12. Hu ZJ, Bai L, Tizabi Y, Southerland W. Computational modeling study of human PubMed
nicotinic acetylcholine receptor for developing new drugs in the treatment of
alcoholism. Interdiscip Sci. 2009 Dec; 1(4):254-62.
13. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Protein fold PubMed
classification with genetic algorithms and feature selection. J Bioinform Comput Biol.
2009 Oct; 7(5):773-88.
14. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Prediction of inter- PubMed
residue contact clusters from hydrophobic cores. Int J Data Min Bioinform. 2008 Dec
11; 2008:703-708.
15. Jackson PL, Scott KR, Southerland WM, Fang YY. Enaminones 8: CoMFA and CoMSIA PubMed
studies on some anticonvulsant enaminones. Bioorg Med Chem. 2009 Jan 01;
17(1):133-40.
16. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, PubMed
Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. The role
of translational research in addressing health disparities: a conceptual framework.
Ethn Dis. 2008; 18(2 Suppl 2):S2-155-60.
17. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, PubMed
Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC.
Addressing health disparities through multi-institutional, multidisciplinary
collaboratories. Ethn Dis. 2008; 18(2 Suppl 2):S2-161-7.
18. Hu Z, Southerland W. WinDock: structure-based drug discovery on Windows-based PubMed
PCs. J Comput Chem. 2007 Nov 15; 28(14):2347-51.
19. Das JR, Fryar-Tita EB, Zhou Y, Green S, Southerland WM, Bowen D. Sequence- PubMed
dependent administration of 5-fluorouracil maintains methotrexate antineoplastic
activity in human estrogen-negative breast cancer and protects against
methotrexate cytotoxicity in human bone marrow. Anticancer Res. 2007 Nov-Dec;
27(6B):3791-9.
20. Hu Z, Bowen D, Southerland WM, del Sol A, Pan Y, Nussinov R, Ma B. Ligand binding PubMed
and circular permutation modify residue interaction network in DHFR. PLoS Comput
Biol. 2007 Jun; 3(6):e117.
21. Fryar-Tita EB, Das JR, Davis JH, Desoto JA, Green S, Southerland WM, Bowen D. PubMed
Raloxifene and selective cell cycle specific agents: a case for the inclusion of
raloxifene in current breast cancer treatment therapies. Anticancer Res. 2007 MayJun; 27(3B):1393-9.
22. Das JR, Fryar-Tita EB, Green S, Southerland WM, Bowen D. Sequence-dependent PubMed
administration of raloxifene and 5-fluorouracil/pemetrexed protects against
pemetrexed cytotoxicity in human bone marrow. Anticancer Res. 2007 Mar-Apr;
27(2):825-33.
23. Nekhai S, Jerebtsova M, Jackson A, Southerland W. Regulation of HIV-1 transcription PubMed
by protein phosphatase 1. Curr HIV Res. 2007 Jan; 5(1):3-9.
24. Ammosova T, Berro R, Jerebtsova M, Jackson A, Charles S, Klase Z, Southerland W, PubMed
Gordeuk VR, Kashanchi F, Nekhai S. Phosphorylation of HIV-1 Tat by CDK2 in HIV-1
transcription. Retrovirology. 2006 Nov 03; 3:78.
25. Das JR, Fryar EB, Green S, Southerland WM, Bowen D. The protection against PubMed
trimetrexate cytotoxicity in human bone marrow by sequence-dependent
administration of raloxifene, 5-fluorouracil/trimetrexate. Anticancer Res. 2006 NovDec; 26(6B):4279-86.
26. Fryar EB, Das JR, Davis JH, Desoto JA, Laniyan I, Southerland WM, Bowen D. PubMed
Raloxifene attenuation of 5-FU/methotrexate cytotoxicity in human breast cancer
cells: the importance of sequence in combination chemotherapy. Anticancer Res.
2006 May-Jun; 26(3A):1861-7.
27. Das JR, Fryar EB, Epie NN, Southerland WM, Bowen D. Raloxifene attenuation of PubMed
methotrexate cytotoxicity in human bone marrow by sequence-dependent
administration of raloxifene, 5-FU/methotrexate. Anticancer Res. 2006 May-Jun;
26(3A):1877-83.
28. Yin J, Bowen D, Southerland WM. Barnase thermal titration via molecular dynamics PubMed
simulations: detection of early denaturation sites. J Mol Graph Model. 2006 Jan;
24(4):233-43.
29. Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, PubMed
Southerland W, Gordeuk VR, Bollen M, Nekhai S. Nuclear targeting of protein
phosphatase-1 by HIV-1 Tat protein. J Biol Chem. 2005 Oct 28; 280(43):36364-71.
30. De Soto JA, Bowen D, Davis JH, Southerland WM, Hawkins M. Sequence- and time- PubMed
dependent antagonism between raloxifene and methotrexate in human breast
cancer cells. Anticancer Res. 2002 Mar-Apr; 22(2A):1007-9.
THANK YOU FOR USING THE RTRN RESEARCH COLLABORATION AND PROFESSIONAL
NETWORKING SERVICE.
RTRN Data Coordinating Center
Mississippi e-Center @ Jackson State University
1230 Raymond Road, Box 1800, Jackson, Mississippi 39204
Phone: 601-979-0332, Fax: 601-979-0338, e-mail: [email protected]