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Curriculum Vitae
Margaret Su-Chun Ho, Ph.D.
Rm 604, Department of Anatomy and Neurobiology
Tongji University School of Medicine,
1239 Siping Road Shanghai China 200092
Birth Place: Hong Kong
Nationality: USA
Tel: +86-21-6598-7838 (lab)
+86-13611852742 (mobile)
Email: [email protected]
EDUCATION
Ph.D., Department of Molecular and Cellular Biology
Harvard University, Cambridge, MA.
1999 - 2003
B.A., Department of Molecular and Cellular Biology, Biochemistry 1995 - 1998
The University of California at Berkeley, CA.
RESEARCH EXPERIENCES
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Professor, Department of Neurobiology and Anatomy, School of Medicine, Tongji
University, 2010 to date
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Institute of Molecular Biology, Academia Sinica, Taiwan, 2003 to 2010
Postdoctoral Fellow in Dr. Cheng-Ting Chien’s laboratory
Project title: Gcm protein degradation mediated by two F-box proteins suppresses
proliferation of glial progenitors (winner of the France-Taiwan Scientific Prize in Sept 2009 )
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Department of Molecular and Cellular Biology, Harvard University, 1999-2003
PhD student in Dr. Richard Losick’s laboratory
Dissertation title: Mechanistic studies on the activation of a cell-specific transcription
factor SigmaF in Bacillus subtilis
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Department of Chemistry and Chemical Biology, Harvard University, 1999
Research assistant in Dr. Greg Verdine’s laboratory
Project title: Finding interaction partners for the DNA damage protein SMUG1
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Department of Molecular and Cellular Biology, University of California at Berkeley,
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1997-1998 Undergraduate research assistant in Dr. Michael Chamberlin’s laboratory
Project title: Mechanisms of transcription elongation
PUBLICATIONS
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Ho, M. S. and Duan, S. (2012) Purinergic Mechanisms in Glial cells, invited book chapter,
Neuroglia, Oxford University Press
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Mao, H. A., Lv, Z. W., Ho, M. S. (2012) Gcm Protein Functions in Developing Nervous
System Dev Biol. 2012 Oct 1;370(1):63-70
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Wu, J. T., Lin, W. H., Ho, M. S., Tang, C.-Y., Chien C. T. (2011) Differential scaling of Ci155
proteolysis by CSN-mediated deneddylation is critical for low threshold response to
Hedgehog signaling Nat Commun. 2011 Feb;2:182.
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Ho M. S., Chen H, Chen M, Jacques C, Giangrande A, Chien C. T. (2009) Gcm protein
degradation mediated by two F-box proteins suppresses proliferation of glial progenitors.
Proc Natl Acad Sci U S A. 106 (16):6778-83 IF: 9.4 number of citations:1
*This article won the France-Taiwan Scientific Prize in Sept 2009 and was featured in the
Asia-Pacific International Molecular Biology Network (A-IMBN)
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Ho, M. S., Ou, C., Chan, Y. R., Chien, C. T., and Pi, H. (2008) the utility F-box for protein
destruction. Review. Cell Mol Life Sci. 65 (13):1977-2000. IF: 6.0 number of citations:19
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Ho, M. S., Tsai, P. I., and Chien, C. T. (2006) F-box proteins: the key to protein degradation.
Review. J. Biomedical Sci., 13: 181–191. IF:2.0 number of citations:30
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Ho, M. S., Carniol, K., and Losick, R. (2003) Evidence in support of a docking model for the
release of the transcription factor SigmaF from the anti-sigma factor SpoIIAB in Bacillus
Subtilis. J. Biol Chem. 278, 20898-20905 IF:5.8 number of citations:29
ORAL AND POSTER PRESENTATIONS
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Ho, M. S. F-box proteins Slimb and Ago regulate the protein stability of the glialpromoting factor Gcm in Drosophila. ION-NPAS-HKUST-NIMH Joint Meeting
“Symposium on Frontiers in Neuroscience”, Shanghai, China, Sept 2009 (also the student
representative from NPAS)
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Ho, M. S. To differentiate or to proliferate as a glial precursor: protein stability matters.
Cold Spring Harbor Meeting on Glial in Health and Disease (section on glial development),
Cold Spring Harbor, New York, USA, July 2008
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Ho, M. S. The regulation of gliogenic master gene glide/gcm by SCF complexes during glial
development in Drosophila. Joint Annual Conference of Biomedical Sciences (section on
protein degradation), Taipei, Taiwan, March 2007
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Ho, M. S. RNAi screening of F-box proteins in Drosophila S2 cells. Joint Annual
Conference of Biomedical Sciences (RNAi section), Taipei, Taiwan, March 2004
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Ho, M. S. A docking model for the release of the transcription factor Sigma F from the
antisigma factor SpoIIAB in Bacillus subtilis. New England Spores Conference, Cambridge,
MA, USA, 2003
GRANTS and AWARDS
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National Natural Science Foundation of China (NSFC) – Mechanisms of F-box protein
CG5003 mediates ubiquitination and protein degradation during Drosophila development,
2013-2016 (国家自然科学基金面上项目- F-box 蛋白 CG5003 介导的泛素化修饰调控果
蝇发育的机制研究 –2013-2016，主要负责人)
National Program on Key Basic Research Project (973 Program) –Fate decision of neural
stem cells and the molecular circuit control, participant (国家重点基础研究发展计划-神
经前体细胞的命运决定、分化及环路形成的分子调控网络–2012-2014，骨干)
National Natural Science Foundation of China (NSFC) – Gcm phosphorylation regulates
Drosophila embryonic glial cell development, 2012-2015 (国家自然科学基金面上项目GCM 磷酸化调控果蝇胚胎胶质细胞发育与功能的机制研究 – 2012-2015，主要负责人)
Central Government Research Fund for Tongji University – Glial cells in
neurodegenerative diseases – using Drosophila as a model (同济大学中央高校专项基金
预研类项目-构建果蝇疾病模型研究胶质细胞对神经退化的作用机制 –2012-2014，主
要负责人)
National Program on Key Basic Research Project (973 Program) – Nucleosome positioning
during Drosophila embryo development, participant (国家重点基础研究发展计划-果蝇
胚胎发育中的核小体重排和染色质高级结构的变化 –2012-2014，骨干)
National Science Council Research Grant and Distinct Postdoctoral Fellowship 96-2321-B001-027-MY2 (F-box 基因调控 gcm 于神经胶细胞之生成), 2007 to 2009
Academia Sinica Postdoctoral Fellowship, 2003 to 2007
IBRO Travel Grant 2007, International Brain Research Organization
IMB Developmental Retreat Poster Award 2007, poster title - “F-box genes slimb and ago
regulate gliogenesis in Drosophila”
EMBO short term fellowship, European Molecular Biology Organization, March to May,
2006 - visiting scientist in the laboratory of Dr. Angela Giangrande, IGBMC, Strasbourg,
France
NIH Teaching Fellowship, 1999 to 2000
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CONTINUING EDUCATION
English for Writing in Science and Industry – certificated by the University of Washington at
Seattle. Completed in June 2007
REFEREES
Dr. Cheng-Ting Chien, Research Fellow
Institute of Molecular Biology, Academia Sinica
128 Academia Road Sec#2 Nankang, Taipei 115, Taiwan
Email: [email protected]
Tel #: 886-2-27883562
Dr. Richard Losick, Professor
Department of Molecular and Cellular Biology, Harvard University
16 Divinity Ave., Cambridge, MA, 02138
Email: [email protected]
Tel #:1-617 495-4905
Dr. Gregory Verdine, Professor
Department of Chemistry and Chemical Biology, Harvard University
12 Oxford Street, Cambridge, MA, 02138
Email: [email protected]
Tel #:1-617 495-5323
Dr. Joseph Chan, Former GSK Employee
6614 Falconbridge Road, Chapel Hill, NC 27517
Email: [email protected]
Tel #:1-919-402-8841
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