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How we treat Richter syndrome by Sameer A. Parikh, Neil E. Kay, and Tait D. Shanafelt Blood Volume 123(11):1647-1657 March 13, 2014 ©2014 by American Society of Hematology Risk factors associated with development of Richter syndrome in patients with CLL. *Data on the role of CLL therapy are controversial, with some studies suggesting they are contributory to the development of RS in CLL patients, and other studies suggesting ... Sameer A. Parikh et al. Blood 2014;123:1647-1657 ©2014 by American Society of Hematology A schematic approach to a patient with suspected RS. *Signs and symptoms suspicious for transformation include: B-type symptoms (weight loss, night sweats, and fever), rapid enlargement of lymph nodes or spleen, hypercalcemia, and increased lactate dehydrog... Sameer A. Parikh et al. Blood 2014;123:1647-1657 ©2014 by American Society of Hematology Overall survival of RS patients seen at Mayo Clinic according to the RS prognosis score. Sameer A. Parikh et al. Blood 2014;123:1647-1657 ©2014 by American Society of Hematology Management of CLL patients with Richter transformation to diffuse large B-cell lymphoma in which no clinical trial is available. ¶The simplest way to determine clonality is to compare the κ and λ light chain restriction between the CLL and the DLBCL. For pa... Sameer A. Parikh et al. Blood 2014;123:1647-1657 ©2014 by American Society of Hematology
