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Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate by Andreas Weigert, Axel M. Johann, Andreas von Knethen, Helmut Schmidt, Gerd Geisslinger, and Bernhard Brüne Blood Volume 108(5):1635-1642 September 1, 2006 ©2006 by American Society of Hematology Apoptotic cells attenuate caspase-3 activation in murine and human macrophages. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Apoptotic cells attenuate macrophage apoptosis. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Macrophage protection caused by an apoptotic cell-derived soluble factor. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Protection of primary human macrophages by ACM is PI3K-, Ca2+-, and ERK1/2-dependent. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Sphingosine-1-phosphate conveys protection. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Measurement of S1P secretion by apoptotic cells. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology Sphk2 expression in apoptotic cells contributes to the release of S1P. Andreas Weigert et al. Blood 2006;108:1635-1642 ©2006 by American Society of Hematology