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Clonal selection in xenografted TAM recapitulates the
evolutionary process of myeloid leukemia in Down
syndrome
by Satoshi Saida, Ken-ichiro Watanabe, Aiko Sato-Otsubo, Kiminori Terui, Kenichi
Yoshida, Yusuke Okuno, Tsutomu Toki, RuNan Wang, Yuichi Shiraishi, Satoru
Miyano, Itaru Kato, Tatsuya Morishima, Hisanori Fujino, Katsutsugu Umeda,
Hidefumi Hiramatsu, Souichi Adachi, Etsuro Ito, Seishi Ogawa, Mamoru Ito,
Tatsutoshi Nakahata, and Toshio Heike
Blood
Volume 121(21):4377-4387
May 23, 2013
©2013 by American Society of Hematology
TAM cells engrafted in NOG mice.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
The NOG mouse model can support self-renewal of TAM-derived cells.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
Sequential CNA analysis of TAM-derived cells in the recipients of patient 1.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
TAM-derived cells show genetic and functional diversity.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
A minor subclone with additional CNAs was present in the primary TAM patient sample, whereas
a new clone emerged in a 1° recipient.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
Serial transplantation and CNA profiling of TAM-derived cells from patients that did not develop
ML-DS.
Satoshi Saida et al. Blood 2013;121:4377-4387
©2013 by American Society of Hematology
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