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Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function by Bree Foley, Sarah Cooley, Michael R. Verneris, Michelle Pitt, Julie Curtsinger, Xianghua Luo, Sandra Lopez-Vergès, Lewis L. Lanier, Daniel Weisdorf, and Jeffrey S. Miller Blood Volume 119(11):2665-2674 March 15, 2012 ©2012 by American Society of Hematology NKG2C+ NK cells increase after CMV reactivation after HCT and produce high levels of IFNγ. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology NKG2C+ NK cells are predominantly KIR+ and education through self-KIR are required for robust IFNγ production. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology CMV reactivation induces an increase of NKG2C+ NK cells and a more mature NK-cell phenotype in the first year after transplantation. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology Expanding NKG2C+ NK cells are more mature (KIR+ and NKG2A−) in the first year after CMV reactivation. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology CD158b+ is preferentially expressed on expanding NKG2C+ NK cells after CMV reactivation. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology CD57 is preferentially acquired on NKG2C+ cells in the first year after CMV reactivation. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology IFNγ production, but not CD107a expression, is increased after CMV reactivation. Bree Foley et al. Blood 2012;119:2665-2674 ©2012 by American Society of Hematology
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