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PELVIC ORGAN PROLAPSE AUC APRIL ‘14 JR SATHIYA HOSPITAL PULAU PINANG DEFINITION • Pelvic organ prolapse is defined as the descent of one or more of the following: • anterior vaginal wall, • posterior vaginal wall, • and apex of the vagina (cervix/uterus) or vault (cuff) after hysterectomy. • Absence of prolapse is defined as stage 0 support; prolapse can be staged from stage I to stage IV IMPORTANCE OF PELVIC ORGAN PROLAPSE TO THE UROLOGIST? • Pelvic organ prolapse can occur in association with UI and other lower urinary tract dysfunction and may on occasion mask incontinence DEFINITION • Anterior vaginal wall prolapse- descent of the anterior vagina so that the urethrovesical junction or any anterior point proximal to this is less than 3 cm above the plane of the hymen. • Prolapse of the apical segment of the vagina is defined as any descent of the vaginal cuff scar (after hysterectomy) or cervix, below a point that is 2 cm less than the total vaginal length above the plane of the hymen. • Posterior vaginal wall prolapse is defined as any descent of the posterior vaginal wall so that a midline point on the posterior vaginal wall 3 cm above the level of the hymen or any posterior point proximal to this is less than 3 cm above the plane of the hymen. FIGURE 1B Stage 0 Hymenal remnants' Stage I Stage II Stage III Stage IV 1898 SECTION XIV ● Urine Transport, Storage, and Emptying 1963 Severity (Porges) 1980 Grading system (Beecham) 1972 Vaginal profile (Baden) Midplane of vagina Straining Grade 1 Slight or 1st degree Hymenal ring Grade 2 Introitus 1996 Quantitative POP (ICS, AUGS, SGS) Stage I 1st degree (–) 1 cm Stage II Straining Straining (+) 1 cm Moderate or 2nd degree Grade 3 2nd degree Complete eversion Marked or 3rd degree Grade 4 3rd degree Stage III Stage IV Figure 64–1. Visual comparison of systems used to quantify pelvic organ prolapse (From Theofrastous JP, Swift SE. The clinical evaluation of pelvic floor dysfunction. Obstet Gynecol Clin North Am 1998;25:783–804.) Key Points: General Considerations ● Pelvic floor disorders (PFDs) are a prevalent worldwide health concern. For the purposes of routine outpatient assessment, this quantification can be achieved on the basis of the number of pads used per day or the frequency of clothing changes due to urinary leakage. In the setting of research or an academic practice, more stringent obstruct the urethra and give a false-negative result. Once stress incontinence is confirmed, the prolapse repair can be combined with surgery for stress incontinence. There is a small risk of overcorrection and voiding dysfunction with this strategy. The other equally common strategy is to do the repair first and deal with any stress incontinence later if it persists. The downside with this is that the patient will need two procedures. If the second option is chosen, there is no need to do bladder studies before the operation because this will have to be repeated Pelvic muscle function • Pelvic floor muscle function can be qualitatively defined by the tone at rest and the strength of a voluntary or reflex contraction as strong, weak, or absent or by a validated grading system (e.g., Oxford 1 to 5). Oxford grading of pelvic floor muscle strength Grade 0 Absent contraction Grade 1 Grade 2 Flicker, trace or minimal Weak contraction – has greater potential for strengthening than grade 0 or 1 Ability to move against mild resistance Ability to move against some resistance Ability to move and hold against resistance Grade 3 Grade 4 Grade 5 Normal/ strong Table 2 • Rectal examination - easiest method of assessing pelvic floor muscle function in children and men. In addition, rectal examination is essential in children with UI to rule out fecal impaction OBSTETRICS, GYNAECOLOGY AND REPRODUCTIVE MEDICINE 18:9 T 242 Relationship between prolapse and incontinence • Patients with severe prolapse may develop voiding symptoms as a result of urethral kinking, leading to obstruction that is worsened during straining effort • For instance, a moderate or severe cystocele may promote urethral compression and kinking, pressure dissipation, and an increase in maximum urethral closure pressures • Detrusor overactivity seen with cystocele. • Occult or latent incontinence is urethral sphincteric incompetence masked by the presence of pelvic prolapse (Rosenzweig et al, 1992). • Incontinent women may note the decrease or disappearance of stress incontinence as the degree of prolapse worsens. Relationship between prolapse and incontinence • A large rectocele may cause incomplete bowel evacuation and tenesmus • The prevalence of fecal incontinence increases to 17% in populations with pelvic organ prolapse and UI • The most common mechanisms are an incompetent sphincteric mechanism (secondary to a structural defect or pudendal nerve damage) and overflow incontinence. Pelvic floor support mechanism • Deficiency causes pelvic organ prolapse or incontinence, or both • Continuum between Hypermobility and Intrinsic Sphincter Deficiency • Urethral Support Mechanisms ISD & hypermobility • In patients with stress incontinence there is a spectrum between the two components of ISD and urethral hypermobility • some patients have primary sphincteric problems, whereas others have an adequately functioning sphincter but significant hypermobility. • The majority lie somewhere between these two extremes. Urethral support mechanism • The urethral support mechanism comprises all the structures extrinsic to the urethra that offer a supportive backplate on which the proximal urethra and midurethra lie • Connective tissue • Pelvic musculature • Support and suspension of the pelvic organs is dependent on a healthy pelvic floor striated muscle, intact robust connective tissue, and their attachment to the bony frame of the pelvis Urethral support mechanism -Connective tissue • Pubourethral ligament attaches the midurethra to the inferior side of the pubic symphysis and prevents its downward rotational descent. • It works in conjunction with the pubourethralis muscle, that forms a sling around the proximal urethra. Forms the midurethral complex • Has been postulated that an elongation of the posterior pubourethral ligaments may be a significant contributory factor to the loss of urethral support seen in stress incontinence Urethral support mechanism -Connective tissue • Endo-pelvic fascia/pubocervical fascia, extending between the bladder and the vagina, suspends and attaches the vagina and cervix to the pelvic sidewall and to each arcus tendineus fascia pelvis, thereby offering posterior support to the bladder and bladder neck. • It has two surfaces: the perivesical fascia on the vaginal side and the endopelvic fascia on the abdominal side. • Its upper zone supports the bladder above the cervix, • the middle zone supports the trigone, and • the lower zone supports the bladder neck. • Laxity of the fascia in each of the zones will result in uterine prolapse, cystocele, and urethrocele, respectively (DeLancey, 2001). Urethral support mechanism -Connective tissue • The arcus tendineus fasciae pelvis are tensile structures located bilaterally on either side of the urethra and vagina that act like the ropes of a suspension bridge and provide the necessary support needed to hang the urethra on the anterior vaginal wall. They originate as fibrous bands from the pubic bone and broaden out as aponeurotic structures moving dorsally to insert into the ischial spine • The cardinal ligaments and the more medially placed uterosacral ligaments support the uterus and cervix; their relaxation results in uterine prolapse. Pubocervical fascia Tendinous arch Pelvis Bladder s ment of r. Cardinal ligament Cervix Uterosacral ligament Figure 63–7. Rectum Sacrum Relationship of ligaments to pelvic organs. Urethral support mechanism - Pelvic musculature • levator ani muscles, carries the weight of the pelvic contents and prevents the abdominal pressure from stretching the ligamentous support structures. • puborectalis • pubococcygeus • iliococcygeus Prevalence • POP based on a sensation of a mass bulging into the vagina ranges between 5% and 10% • prolapse occurs most frequently in the anterior compartment, next most frequently in the posterior compartment, and least in the apical compartment. • Two studies that examined prolapse by race found that black women had the lowest prevalence and Hispanic women the highest Table 3. Risk Factors for Prolapse From the WHI Risk Factors Moderate Increased Risk No Increased Risk Age Waist circumference Education Race Increasing parity Occupation Body mass index Constipation Quality of life Parity Chronic illness Time since menopause Breast-feeding Hysterectomy Past smoking Coffee consumption Physical activity WHI indicates Women’s Health Initiative. Adapted from Hendrix SL, Clark A, Nygaard I, Aragaki A, Barnabei V, McTiernan A. Pelvic organ prolapse in the Women’s Health Initiative: gravity and gravidity. Am J Obstet Gynecol. 2002;186(6):1160-1168. about twice the rate of cystocele compared with white women.The large cohort allowed for multivariate analysis of these data, thus eliminating confounding factors such as number of vaginal births and body mass index (BMI; in kg/m2) when comparing relative risk. lapse in this cohort of women after menopause.”8 They go on to say that an even higher rate of POP might have been found were the study subjects examined at a 45-degree angle using the POP-Q rather than in the supine position. EVALUATION OF PATIENT History • History of present illness • Incontinence; Stress, Urgency incontinence, without sensory awareness? • Quantification of leakage • Voiding pattern; Frequency, daytime/night time • Duration of symptoms and inciting event • QOL & bother History • Previous pelvic surgery • Obstetric history • Neurological condition • Trauma • Radiation therapy • Current medications Physical examination • Abdominal examination • Examination of external genitalia • Pervaginal examination • Urethral mobility test (Q-tip test) <30% : Normal • POP-Q • Neurological examination • DRE Table 64–4. Components of a Focused Pelvic Examination • Inspection and palpation of breasts (e.g., masses or lumps, tenderness, symmetry nipple discharge) • Digital rectal examination including sphincter tone, presence of hemorrhoids, rectal masses Pelvic examination (with or without specimen collection for smears and cultures) including: • External genitalia (e.g., general appearance, hair distribution, lesions) • Urethral meatus (e.g., size, location, lesions, prolapse) • Urethra (e.g., masses, tenderness, scarring) • Bladder (e.g., fullness, masses, tenderness) • Vagina (e.g., general appearance, estrogen effect, discharge, lesions, pelvic support, cystocele, rectocele) • Cervix (e.g., general appearance, lesions, discharge) • Uterus (e.g., size, contour, positions, mobility, tenderness, consistency, descent or support) • Adnexa/parametria (e.g., masses, tenderness, organomegaly, nodularity) • Anus and perineum • The POP-Q At press time, 7 of 11 bullet points listed above are required to be considered a complete female genitourinary examination. However, other organ systems/ body areas not limited to the genitourinary system may be included in a report to accomplish the requirements of various levels of examination. Data from Centers for Medicare/Medicaid (CMS): Single organ system examination—Genitourinary: 1997 Documentation Guidelines for Evaluation and Management (E/M) Services, jointly approved by the American Medical Association and HCFA with revisions November, 1997. • Done in lithotomy and standing • With Valsalva to the patient during insertion of the Q-tip can be minimized with the use of intraurethral lidocaine jelly. The Q-tip is inserted into the bladder through the urethra, and the angle that the Q-tip moves from horizontal to its final position with straining is measured. Hypermobility is defined as a Q-tip angle of greater than 30 degrees from horizontal. Assessment of prolapse should ideally be performed in both the lithotomy and standing positions, the latter facilitated by having the patient stand with one foot elevated on a short stool. Each compartment—the anterior, posterior, and apical (uterus/cervix or vaginal cuff)—should be evaluated methodically and the perineal body assessed for laxity. A complete systematic examination is performed using two posterior blades of a split Grave speculum with and without straining. First, one blade is used to retract the posterior wall to facilitate anterior compart- • Tedious A Point Description Range of values Aa Anterior vaginal wall 3 cm proximal to the hymen –3 cm to +3 cm Ba Most distal position of remaining upper anterior vaginal wall –3 cm to +tvl C Most distal edge of cervix or vaginal cuff scar – D Posterior fornix (N/A if post-hysterectomy) – Ap Posterior vaginal wall 3 cm proximal –3 cm to +3 cm to the hymen Bp Most distal position of remaining upper posterior vaginal wall gh (genital hiatus) Measured from middle of external urethral meatus to posterior midline hymen – pb (perineal body) Measured from posterior margin of gh to middle of anal opening – tvl (total vaginal length) Depth of vagina when point D or C is reduced to normal position – –3 cm to +tvl Aa Ba XX X C Bp X X Ap –3 4.5 +2 Aa gh Ap –3 1 +5 Ba pb Bp –6 8 C septum. Demonstra rior pressure applied ter tone, which is a important in neuro voluntarily tighten flow of urine midst suggest a possible patient lack of unde the specific muscle In men, genitou function should al stenosis and, particu urinary leakage wi leakage is ideally position. tvl –– Figure 64–3. Line drawing example of posterior support defect. The anterior compartment is well supported. The leading point of the prolapse is point Bp (+5), which is 5 cm beyond the hymen. Total vaginal length is 8 cm, and point C (−6), the cuff position, has descended 2 cm. (From Bump RC, Mattiasson A, Bo K, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol 1996;175:10–7.) Key Points: Evalu A properly per the evaluation ● The Centers fo of both male a to meet codin ● Assessment of performed in b ● Several classifi able for assess ● SUPPLEMENTAL EVALUATION Supplemental evaluation • Urinalysis • Post Void residual • Bladder diaries ( ICS requires 3 days) • Pad Test (1 day, 1.3g is significant) Supplemental investigation • Urodynamics • Voiding cystourethrogram • Dynamic MRI TREATMENT Non Operative Treatment Figure 5. Pessaries • Watchful waiting • Pelvic Floor Exercise • Pessaries Photo courtesy of Cooper Surgical. us tio tra na ca Pa du flo T is an of Pe Pe an ap sh M th th be Operative Treatment • The goal of POP repair is to restore the normal anatomy and function of the vagina and the lower urinary and GI tracts. • The decision regarding whether to proceed with a transvaginal or a transabdominal approach is dependent on • which of the three compartments is affected, • the degree of prolapse, and • patient and surgeon preference Decade among United States Urologists http://dx.doi.org/10.1016/j.juro.2013.10.076 Vol. 191, 1022-1027, April 2014 Printed in U.S.A. with this condition undergo surgical treatment.1 The lifetime risk of prolapse surgery in a woman in the United States is 11% to 19% by age 80 Changes in Pelvic Organ Prolapse Surgery in the Last Decade among United States Urologists Dean S. Elterman,* Bilal I. Chughtai,* Emily Vertosick, Alexandra Maschino, James A. Eastham and Jaspreet Sandhu†,‡ Dean S. S. Elterman,* Bilal I. Chughtai,* Emily Vertosick, Alexandra Maschino, James A. Eastham and Jaspreet S. Sandhu†,‡ From the Division of Urology, Department of Surgery, University Health Network, University of Toronto (DSE), Toronto, Ontario, From the Division of Urology, Department of Surgery, University Health Network, University of Toronto (DSE), Toronto, Ontario, Canada and Brady Department of Urology, Weill Cornell Medical College (BIC), and Department of Epidemiology Biostatistics Canada and Brady Department of Urology, Weill Cornell Medical College (BIC), and Department of and Epidemiology and Biostatistics AM), and (JAE, Urology Service, Surgery (JAE, JSS), Memorial Sloan-Kettering Cancer York, Center, New New York, New York (EV, AM), and Urology Service, Department of(EV,Surgery JSS), Department Memorialof Sloan-Kettering Cancer Center, New York Abbreviations and Acronyms ABU ¼ American Board of Urology FDA ¼ Food and Drug Administration 0022-5347/14/1914-1022/0 THE JOURNAL OF UROLOGY® © 2014 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC. POP ¼ pelvic organ prolapse PELVIC organ prolapse is a common condition that affects about half of women and correlates with increasing age.1 Approximately 10% of women Accepted for publication October 11, 2013. Supported by the Sidney Kimmel Center for Prostate and Urological Cancers, Memorial Sloan-Kettering Cancer Center. * Equal study contribution. † Correspondence: Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, Sidney Kimmel Center for Prostate and Urologic Cancers, 353 East 68th St., New York, New York 10065 (e-mail: sandhuj@mskcc. org). ‡ Financial interest and/or other relationship with American Medical Systems. Purpose: Surgical correction of pelvic organ prolapse underwent transformation Abbreviations Purpose: Surgical correction of pelvic organ prolapse underwent in the last decade. Training in pelvic organ prolapse surgery, the transformation ease of mesh kit and Acronyms use, and Food and Drug Administration warnings about mesh have influenced in lastBoard decade. Training in pelvic organ prolapse surgery, the ease of mesh kit ABUthe ¼ American of practice patterns. We investigated trends in pelvic organ prolapse procedures. Urology and Food and Drug Administration warnings about mesh have influenced use, Materials and Methods: Case logs of pelvic organ prolapse procedures, mesh use FDA ¼ Food and Drug and pessary placement were obtained from the American Board of Urology for practice Administration patterns. We investigated trends in pelvic organ prolapse procedures. 2003 to 2012. We evaluated associations between surgeon characteristics and the POP ¼ pelvic organ prolapse Materials and Methods: logs prolapse of pelvic organ prolapse procedures, mesh use use ofCase pelvic organ procedures. Results: Of 6,355 nonpediatric applying for Board certification recertifi- for and placement were obtained fromurologists the American of orUrology Acceptedpessary for publication October 11, 2013. cation 2,192, representing a 10% annual sample of all urologists, reported perSupported by the Sidney Kimmel Center for 2003 to 2012. We evaluated associations between surgeon and the Prostate and Urological Cancers, Memorial forming pelvic organ prolapse procedures during thecharacteristics study period. The number Sloan-Kettering Cancer Center. of procedures increased steadily from 930 in 2003 to 6,978 in 2012. The number use of pelvic organ prolapse procedures. * Equal study contribution. of colporrhaphies increased from 806 to 2,670 and the number of colpopexies † Correspondence: Urology Service, DepartResults: OfSloan-Kettering 6,355Can- nonpediatric urologists applying for 2012. certification recertifiment of Surgery, Memorial increased from 32 to 1,414 between 2003 and The number or of vaginal cer Center, Sidney Kimmel Center for Prostate colpopexies increased from 24 sample to 1,016 during theurologists, study period. The number ofpercation 2,192, representing a 10% annual of all reported and Urologic Cancers, 353 East 68th St., New sacrocolpopexies increased from 8 to 398 with exponential increases in laparoYork, New York 10065 (e-mail: sandhuj@mskcc. forming pelvic organ scopic prolapse procedures during the Mesh studyinsertion period. The number org). sacrocolpopexy (282 cases by 2012). increased from ‡ Financial interest and/or other relationship 10 cases reportedfrom by applicants 2005 toto 1,552 reported in 2012 (p <0.0005). ofAmerican procedures increased steadily 930 inin2003 6,978 in 2012. The number with Medical Systems. Mesh revision, first reported in 2007 with 52 performed, consistently increased to of colporrhaphies increased 806 to 2,670 the number of ofcolpopexies 214 in 2012.from Urologists trained in femaleand urology performed a median 16 pelvic prolapse procedures, double the number by surgeonsoftrained increased from 32 toorgan 1,414 between 2003 and 2012. reported The number vaginal other urological fellowships. Urologists of the female gender also reported colpopexies increasedin from 24 to 1,016 during the study period. The number of performing approximately 8 more procedures annually than male urologists. sacrocolpopexies increased from to 398 with exponential increases in laparoConclusions: The8number of pelvic organ prolapse operations done by urologists increased last decade with insertion a similar increase in mesh use. scopic sacrocolpopexy (282 dramatically cases byin the 2012). Mesh increased from More colpopexies are now performed with laparoscopic sacrocolpopexy showing 10 cases reported by an applicants in 2005 1,552 reported in 2012 (p <0.0005). exponential increase. Theto recent trend of mesh revision is notable with a much faster rate of increase than mesh insertion. Mesh revision, first reported in 2007 with 52 performed, consistently increased to 214 in 2012. Urologists trained in female urology performed a median of 16 pelvic Key Words: pelvic organ prolapse; reoperation; surgical mesh; physicians, physician’s practiceby patterns organ prolapse procedures, double thewomen; number reported surgeons trained in other urological fellowships. Urologists of the female gender also reported performing approximately 8 more procedures annually than male urologists. with this condition undergo surgical PELVIC organ prolapse is a common 1 The done lifetimeby riskurologists of procondition affects about prolapse half of treatment. Conclusions: The number ofthat pelvic organ operations lapse surgery in a woman in the women and correlates with increasing increased dramatically in the last decade with a similar increase in mesh use. United States is 11% to 19% by age 80 age.1 Approximately 10% of women More colpopexies are now performed with laparoscopic sacrocolpopexy showing http://dx.doi.org/10.1016/j.juro.2013.10.076 0022-5347/14/1914-1022/0 an exponential increase. The recent trend of mesh revision is notable with a Vol. 191, 1022-1027, April 2014 THE JOURNAL OF UROLOGY 1022 j www.jurology.com Printed in U.S.A. © 2014 by A U A E R ,I . much faster rate of increase than mesh insertion. ® MERICAN ROLOGICAL SSOCIATION DUCATION AND ESEARCH NC EAU 2013 Evidence summary Women with prolapse + UI s3URGERYFOR0/035)SHOWSAHIGHERRATEOFCUREINTHESHORTTERMTHAN0/0SURGERYALONE s4HEREISCONFLICTINGEVIDENCEONTHERELATIVEBENEFITOFCOMBINEDSURGERYLONGTERM s#OMBINEDSURGERYFOR0/035)CARRIESAHIGHERRISKOFADVERSEEVENTS Continent women with POP s!REATRISKOFDEVELOPING5)POSTOPERATIVELY s4HEADDITIONOFAPROPHYLACTICANTIINCONTINENCEPROCEDUREREDUCESTHERISKOFPOSTOPERATIVE5) s4HEADDITIONOFAPROPHYLACTICANTIINCONTINENCEPROCEDUREINCREASESTHERISKOFADVERSEEVENTSTO the same extent Women with prolapse and occult SUI s3URGERYFOR0/035)SHOWSAHIGHERRATEOFCUREINTHESHORTTERMTHAN0/0SURGERYALONE s#OMBINEDSURGERYFOR0/035)CARRIESAHIGHERRISKOFADVERSEEVENTS LE Recommendations for women requiring surgery for bothersome POP who have symptomatic or unmasked stress urinary incontinence Offer simultaneous surgery for POP and stress urinary incontinence. Warn women of the increased risk of adverse events with combined surgery compared to prolapse surgery alone. Recommendations for women requiring surgery for bothersome POP without symptomatic or GR 1a 1b 1b 1a 1b 1b 1a 1b A A GR s#OMBINEDSURGERYFOR0/035)CARRIESAHIGHERRISKOFADVERSEEVENTS Continent women with POP s!REATRISKOFDEVELOPING5)POSTOPERATIVELY s4HEADDITIONOFAPROPHYLACTICANTIINCONTINENCEPROCEDUREREDUCESTHERISKOFPOSTOPERATIVE5) s4HEADDITIONOFAPROPHYLACTICANTIINCONTINENCEPROCEDUREINCREASESTHERISKOFADVERSEEVENTSTO the same extent Women with prolapse and occult SUI s3URGERYFOR0/035)SHOWSAHIGHERRATEOFCUREINTHESHORTTERMTHAN0/0SURGERYALONE s#OMBINEDSURGERYFOR0/035)CARRIESAHIGHERRISKOFADVERSEEVENTS 1b Recommendations for women requiring surgery for bothersome POP who have symptomatic or unmasked stress urinary incontinence Offer simultaneous surgery for POP and stress urinary incontinence. Warn women of the increased risk of adverse events with combined surgery compared to prolapse surgery alone. Recommendations for women requiring surgery for bothersome POP without symptomatic or unmasked stress urinary incontinence Warn women that there is a risk of developing de novo stress urinary incontinence after prolapse surgery. Inform women that the benefit of prophylactic stress urinary incontinence surgery is uncertain. Warn women that the benefit of surgery for stress urinary incontinence may be outweighed by the increased risk of adverse events with combined surgery compared to prolapse surgery alone. POP = pelvic organ prolapse. GR EAU 2013 1a 1b 1b 1a 1b A A GR A C A 5.3.1.2 References 1. Maher CM, Feiner B, Baessler K, et al.Surgical management of pelvic organ prolapse in women: the UPDATEDSUMMARYVERSION#OCHRANEREVIEW)NT5ROGYNECOL*.OV http://www.ncbi.nlm.nih.gov/pubmed/21927941 teşekkürler (Thanks)