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Meiosis During meiosis, but NOT mitosis, the homologous chromosomes "find" each other and pair up, lying side by side. During this time, an important process called Crossing over occurs: Crossing over: sections of chromosomes from homologues are swapped (or "synapse")- but only during prophase I of meiosis, when homologues are paired. In humans, 2-3 cross-over events occur per chromosome pair. The result: chromosomes after meiosis are genetically unique and have combinations of DNA derived from both parents. Prophase I: Homologues are paired up Metaphase I: Homologues align in pairs Anaphase I: Homologues separate; sister chromatids remain attached. Telophase I (not shown): 2 new cells form. Each has 1 copy of each homologue, but still has duplicated sister chromatids Meiosis II: Goal: Separate the sister chromatids. This is essentially a mitotic division Prophase II (not shown): Chromosomes [sister chromatids] condense Metaphase II (not shown): Chromosomes [sister chromatids] align at the metaphase plate Anaphase II (not shown): Chromosomes [sister chromatids] separate Telophase II (not shown): Chromosomes [sister chromatids] separate. There are now 4 haploid (n) cells Summary: At the end of meiosis, 4 daughter cells are formed = eggs or sperm. Each contains half as many chromosomes as the parent cell (n); each cell is genetically different from its parents and from its "siblings". Fertilization of an egg by a sperm restores the chromosome number to 2n. Alteration of Generations: All sexually reproducing organisms (animals, plants and fungi) alternate between haploid (n) and diploid (2n) states. Genetic variation "reshuffling the genes" comes from several sources: Ok...people may say that you may have your mom's nose and your dad's hair, but what does that mean? Why do you look different (but somewhat similar) from your brothers and sisters, and from your parents, if you all basically have the same chromosomes? Each meiosis and fertilization is literally like a 'roll of a dice' - so no two individuals are alike! 1. Crossing Over: The chromosomes you receive from your mom's egg and your dad's sperm and NOT the same chromosomes that your mom and dad have. They are new, 'shuffled' versions of their chromosomes - and you only get ONE of them from each parental unit.... 2. Independent assortment: Homologues line up or "shuffle" randomly on the metaphase plate in Meiosis I. With 23 chromosomes assorting independently, there are 223, or 8 million, possible assortments of chromosomes inherited for every cell!! 3. Random fertilization: The ovum has 8 million possible chromosome combinations, so does the sperm cell. 8 million x 8 million = 64 trillion possible diploid combinations in EACH AND EVERY zygote! WOW!! In other words, you're unique...(...just like everyone else.....). The birds 'n the bees: (we'll be brief here).... During sexual reproduction, fertilization of the ovum (n, 23 chromosomes) by the sperm (n, 23 chromosomes) restores the diploid number and creates a zygote (2n, 46) (awww..) that divides and grows by mitosis to form a multicellular human. The former zygote ~ 1 year after fertilization..... Cute, multicellular, and diploid... Instructions not included.