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A. Mean difference in the lumbar spine areal BMD Z-score in published, controlled trials of bisphosphonate therapy for the treatment of children with
osteoporosis, with comparison of results for the treatment versus placebo/untreated control groups. Studies were included with the following criteria: 1. At
least 10 patients per group; 2. prospective design with a placebo or untreated control arms; 3. available data on either the pre- and post-treatment change
in LS BMD Z-score with standard error OR the percent change in LS BMD Z-score. *Details about the magnitude of the mean change in LS BMD Z-score
were not reported; however, the effect size with 95% CI was provided. &Seikaly (2005)533 was a placebo-controlled crossover study design with the results
from the first year of the study presented. $Bishop (2013)448 reported least-squares mean difference. B. Relative risk of vertebral and non-vertebral
Source: Disorders of Calcium, Phosphate, and Bone Metabolism, Pediatric Endocrinology and Inborn Errors of Metabolism, 2e
fractures in published, controlled trials of intravenous or oral bisphosphonate therapy for the treatment of children with osteoporosis, with comparison of
Citation:
K, Hoffmann
GF, Roth
KS. Pediatric
Endocrinology
andStudies
Inborn were
Errorsincluded
of Metabolism,
2e; 2017
the number of
childrenSarafoglou
with fractures
in the treatment
versus
placebo/untreated
groups.
in the figure
if theyAvailable
met the at:
following criteria:
http://mhmedical.com/
Accessed:
August
02,
2017
1. At least 10 patients per group; 2. prospective design with a placebo or untreated control arm; and 3. available data on the number of patients with
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fractures in each
group.
C. The
incidence Education.
rate ratio in
controlled trials of intravenous or oral bisphosphonate therapy for the treatment of
children with osteoporosis with comparison of the number of fracture events in the treatment versus placebo/untreated control groups. Studies were