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Superparamagnetic Iron Oxide Nanoparticles dispersed in Pluronic F127 Hydrogel: Potential Uses in
Topical Applications
P. S. Haddad1, L. C. Gonçalves1 A. B. Seabra2 M. T. Pelegrino1, D. R. de Araujo2 J. S. Bernardes3
1
Exact and Earth Sciences Departament, Federal University of São Paulo, CEP 09913030, Diadema, SP,
Brazil.
2 Human and Natural Sciences Center, Universidade Federal do ABC, UFABC, Santo André, SP, Brazil
3
Brazilian Center for Research in Energy and Materials, CNPEM, Campinas, SP, Brazil
Email:[email protected]
The present work is focused on the synthesis and characterization of nitric oxide (NO)-releasing
superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel
with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by
thermal decomposition of acetylacetonate iron (Fe(acac)3), and coated with the thiol containing molecule
mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized by
different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, at solid
state, and a superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have average hydrodynamic
sizes of (78.0 ± 0.9) nm, average size distribution (PDI) of 0.302 ± 0.04, and zeta potential of (-22.10 ± 0.55)
mV. Free thiol groups on the Fe3O4-MSA NPs surface were nitrosated by the addition of sodium nitrite,
yielding S-nitrosated magnetic nanoparticles (Fe3O4-S-nitroso-MSA NPs), which act as spontaneous NO
donor upon S-N bond cleavage. The amount of (86.4 ± 4.7) μmol of NO was released per gram of Fe 3O4-Snitroso-MSA NPs. In order to enhance NPs dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127
hydrogel (3.4% w/w), and characterized by different techniques [1]. Rheological measurements suggest a
potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force
microscopy (AFM) shown that the NPs are embedded within the Pluronic film while X-ray photoelectron
spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon
and sulfur, confirming the MSA molecule on NPs surface.
1. L. C. Gonçalves, A. B. Seabra, M. T. Pelegrino, D. R. de Araujo, J. S. Bernardes and P. S. Haddad, RSC
Advances, 7, 14496 (2017).
Presentation Method (Poster/ Invited Oral 15/20/25/30minutes): Invited oral 20 minutes
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