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The quantitative assessment of body iron
by James D. Cook, Carol H. Flowers, and Barry S. Skikne
Blood
Volume 101(9):3359-3363
May 1, 2003
©2003 by American Society of Hematology
Calibration of the ratio of serum transferrin receptor to serum ferritin with body iron.Positive
values represent storage iron, and negative values indicate tissue iron deficiency.3 Vertical bars
represent ± 2 SEM. Reprinted from Skikne et al3 with permission.
James D. Cook et al. Blood 2003;101:3359-3363
©2003 by American Society of Hematology
Effect of age on body iron.All values for body iron are positive and indicate the amount of
storage iron.
James D. Cook et al. Blood 2003;101:3359-3363
©2003 by American Society of Hematology
Cumulative frequency distributions of body iron calculated from the ratio of the serum
transferrin receptor to serum ferritin.The clear area and positive values indicate storage iron,
and the shaded area and negative values indicate tissue iron deficiency.
James D. Cook et al. Blood 2003;101:3359-3363
©2003 by American Society of Hematology
Changes in body iron in a trial of iron supplementation in pregnant Jamaican women.A control
group received no additional iron, an FeSO4 group received 100 mg iron daily, and a GDS group
received 50 mg iron daily.
James D. Cook et al. Blood 2003;101:3359-3363
©2003 by American Society of Hematology
Effect of iron fortification on body iron in anemic Vietnamese women.Body iron was calculated
from the ratio of serum transferrin receptor to serum ferritin.
James D. Cook et al. Blood 2003;101:3359-3363
©2003 by American Society of Hematology