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Andrea N. Burnett-Hartman Fred Hutchinson Cancer Research Center 1100 Fairview Ave. N., M4-B402 Seattle, WA 98109 206-667-2126 Email: [email protected] EDUCATION 2010 Doctor of Philosophy, University of Washington, School of Public Health, Department of Epidemiology, Seattle, WA 2002 Master of Public Health, University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI 2000 Bachelor of Philosophy (focus Microbiology and Ecology), Miami University, Interdisciplinary Studies Program, Oxford, OH RESEARCH & PROFESSIONAL EXPERIENCE Faculty-level Staff Scientist, Fred Hutchinson Cancer Research Center in Seattle, WA (2012-present) Generate original research questions related to pathways for colorectal cancer, prepare new research grants, carry out research investigations, disseminate findings through publications and meeting presentations, and mentor graduate students KL2 Scholar, University of Washington in Seattle, WA (2012-present) Develop new skills in translational research, including health economics and comparative-effectiveness research, and apply these methods to colorectal cancer screening research Post-doctoral Research Associate, Fred Hutchinson Cancer Research Center in Seattle, WA (2010-2012) Coordinated a team of investigators in meeting the specific aims of three separate NIH funded research awards related to colorectal neoplasia, carried out research investigations, and disseminated findings through publications and meeting presentations Pre-doctoral Research Associate, Fred Hutchinson Cancer Research Center in Seattle, WA (2007-2010) Designed and conducted studies evaluating the etiology of colorectal neoplasia, wrote grants (3 successfully funded), coordinated data collection, developed protocols, performed data analyses, prepared manuscripts for publication, and presented at national meetings Research Assistant, Department of Epidemiology, University of Washington in Seattle, WA (2005-2008) Assisted in the completion of a pilot study of BMI and inflammation in 22 sets of twins from the University of Washington Twin Registry and conducted data analysis and prepared a manuscript on dietary supplement use in middle-aged and older Americans Epidemiologist, West Virginia Dept. of Health in Charleston, WV (2002-2004) Conducted program evaluation of West Nile Virus surveillance and the multistate, US Department of Agriculture Oral Rabies Vaccination Program, presented at quarterly local health department trainings on various public health topics, assisted local health departments in outbreak investigation and did phone consults to the public and practitioners on various issues related to infectious disease control and prevention Emergency Preparedness Intern, Wyoming Dept. of Health in Cheyenne, WY (Summer 2002) Facilitated community bioterrorism response exercises in counties across the state of Wyoming using CDC guidelines to design and conduct exercises responding to Anthrax, Smallpox or Tularemia and provided presentations to medical, emergency management, law enforcement, and public health professionals about these bioterrorism agents working with the community to plan, carryout, and evaluate exercises Research Assistant, Prostate Cancer Genetics Project (PCGP), University of Michigan (2001-2002) Recruited and enrolled new subjects into the study, examined pedigrees, and collected family history information Public Health Intern, Thai Youth AIDS Prevention Project (TYAP) in Chiang Mai, Thailand (Summer 2001) Conducted a survey on HIV knowledge, attitudes and risk behavior in college students at Chiang Mai University and assisted in editing and writing grant proposals TEACHING EXPERIENCE Teaching Assistant, Department of Epidemiology, University of Washington in Seattle, WA (Spring 2010) Developed presentation materials, assisted in writing exams and exercises, held office hours, and lectured once per week for an undergraduate epidemiology course under the direction of Dr. Jack Goldberg Teaching Assistant, Department of Epidemiology, University of Washington in Seattle, WA (Autumn 2007) Assisted Dr. Ron DiGiacomo in developing a new course exploring chronic disease with infectious etiology and attended all classes, assisted with discussions, and drafted course assignments AWARDS/HONORS Cancer Epidemiology and Biostatistics Pre-doctoral Fellowship, National Institutes of Health (2006-2009) Scholar-in-Training Award, American Association for Cancer Research (2009) New Investigators Workshop Participant/Travel Award, American Society of Preventive Oncology (2009) Women in Cancer Research Scholar Award, American Association for Cancer Research (2012) KL2 Research Scholar, National Institutes of Health and the Institute of Translational Health Sciences, University of Washington (2012) MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS American Public Health Association Society for Epidemiologic Research American Association for Cancer Research EDITORIAL SERVICE / REVIEWER British Journal of Cancer American Journal of Epidemiology Cancer Causes and Control Cancer Epidemiology, Biomarkers, and Prevention Cancer Research Gut International Journal of Cancer International Journal of Infectious Disease Nutrition and Cancer PUBLICATIONS Lopez AS, Burnett-Hartman AN, Nambiar R, Ritz L, Owens P, Loparev VN, Guris D, Schmid DS. Transmission of a newly characterized strain of varicella-zoster virus from a patient with herpes zoster in a long-term-care facility, West Virginia, 2004. J Infect Dis 2008;197:646-53. Burnett-Hartman AN, Newcomb PA, Potter JD. Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus. Cancer Epidemiol Biomarkers Prev 2008;17:2970-9. Burnett-Hartman AN, Fitzpatrick AL, Gao K, Jackson SA, Schreiner PJ. Supplement use contributes to meeting recommended dietary intakes for calcium, magnesium, and vitamin C in four ethnicities of middle-aged and older Americans: the Multi-Ethnic Study of Atherosclerosis. J Am Diet Assoc 2009;109:422-9. Wernli KJ, Newcomb PA, Wang Y, Makar KW, Shadman M, Chia VM, Burnett-Hartman AN, Wurscher MA, Zheng Y, Mandelson MT. Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps. Growth Horm IGF Res 2010;20:305-9. Meulepas JM, Newcomb PA, Burnett-Hartman AN, Hampton JM, Trentham-Dietz A. Multivitamin supplement use and risk of invasive breast cancer. Public Health Nutr 2010;13:1540-5. Adams SV, Newcomb PA, Burnett-Hartman AN, White E, Mandelson MT, Potter JD. Circulating 25hydroxyvitamin-D and risk of colorectal adenomas and hyperplastic polyps. Nutr Cancer 2011;63:319-26. Burnett-Hartman AN, Newcomb PA, Mandelson MT, Adams SV, Wernli KJ, Shadman M, Wurscher MA, Makar KW. Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms. Nutr Cancer 2011;63:583-92. Coghill AE, Newcomb PA, Campbell PT, Burnett-Hartman AN, Adams SV, Poole EM, Potter JD, Ulrich CM. Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer. Gut 2011;60:491-8. Burnett-Hartman AN, Newcomb PA, Mandelson MT, Galloway DA, Madeleine MM, Wurscher MA, Carter JJ, Makar KW, Potter JD, Schwartz SM. No evidence for human papillomavirus in the etiology of colorectal polyps. Cancer Epidemiol Biomarkers Prev 2011;20:2288-97. Burnett-Hartman AN, Fitzpatrick AL, Kronmal RA, Psaty BM, Jenny NS, Bis JC, Tracy RP, Kimura M, Aviv A. Telomere-associated polymorphisms correlate with cardiovascular disease mortality in Caucasian women: the Cardiovascular Health Study. Mech Ageing Dev 2012;133:275-81. Burnett-Hartman AN, Newcomb PA, Phipps AI, Passarelli MN, Grady WM, Upton MP, Zhu LC, Potter JD. Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer. Am J Gastroenterol 2012;107:1213-9. Burnett-Hartman AN, Newcomb PA, Schwartz SM, Bostick RM, Pawlita M, Waterboer T, Potter JD. No association between antibodies to sexually transmitted infections and colorectal hyperplastic polyps in men: Minnesota Cancer Prevention Research Unit Polyp Study. Cancer Epidemiol Biomarkers Prev 2012;21:1599-601. Phipps AI, Buchanan DD, Makar KW, Burnett-Hartman AN, Coghill AE, Passarelli MN, Baron JA, Ahnen DJ, Win AK, Potter JD, Newcomb PA. BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. Cancer Epidemiol Biomarkers Prev 2012;21:1792-8. Burnett-Hartman AN, Feng Q, Popov V, Kalidindi A, Newcomb PA. Human papillomavirus DNA is rarely detected in colorectal carcinomas and not associated with microsatellite instability: The Seattle Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev 2013;22:317-9. Burnett-Hartman AN, Passarelli MN, Adams SV, Upton MP, Zhu L, Potter JD, Newcomb PA. Differences in epidemiologic risk factors for adenomas and serrated polyps by anatomic site and lesion severity. Am J Epidemiol 2013;177:625-37. Burnett-Hartman AN, Newcomb PA, Potter JD, Passarelli MN, Phipps AI, Wurscher MA, Grady WM, Zhu L, Upton, MP, Makar KW. Genomic Aberrations Occurring in Subsets of Serrated Colorectal Lesions but not Conventional Adenomas. Can Res 2013;73:2863-72. Huller MAJ, Burnett-Hartman AN, Lampe JW. Gut microbes, diet, and cancer. In: Advances in Nutrition and Cancer (F Della Ragione and V Zappio, eds) NY: Springer, 2013. Passarelli MN, Newcomb PA, Makar KW, Burnett-Hartman AN, Phipps AI, David SP, Hsu L, Harrison TA, Hutter CM, Duggan DJ, White E, Chan AT, Peters U. No association between germline variation in catechol-Omethyltransferase and colorectal cancer survival in postmenopausal women. Menopause. 2013 Jul 22. [Epub ahead of print] PRESENTATIONS Burnett-Hartman AN, Fitzpatrick AL, Gao K, Jackson SA, Schreiner PJ. Supplement use contributes to meeting recommended dietary intakes for calcium, magnesium and vitamin C in four ethnicities of middle-aged and older Americans: The Multi-Ethnic Study of Atherosclerosis. Poster presented at the American Public Health Association Meeting 2006. Burnett-Hartman AN, Newcomb PA, Schwartz SM, Potter JD, Mandelson MT, Galloway DA. The association between human papillomavirus and colorectal polyps. Poster presented at the American Society of Preventive Oncology Meeting 2009. Burnett-Hartman AN., Newcomb PA, Adams SV, Mandelson MT, Wernli KJ, Wang Y, Shadman M, Makar KW. Colorectal polyp type and the association with smoking, charred meat intake, and mEH. Poster presented and press conference at the American Association for Cancer Research Meeting 2009. Burnett-Hartman AN, Newcomb PA, Schwartz SM, Potter JD, Mandelson MT, Madeleine MM, Carter JJ, Galloway DA. HPV seropositivity is not broadly associated with colorectal polyps except for hyperplastic polyps in previously polyp-naïve men. Poster presented at the American Society of Preventive Oncology Meeting 2010. Burnett-Hartman AN, Newcomb PA, Mandelson MT, Phipps AI, Passarelli MN, Upton MP, Zhu L. Sigmoidoscopy and colonoscopy are inversely associated with both left- and right-sided advanced adenomas. Oral presentation at the American Society of Preventive Oncology Meeting, 2011. Burnett-Hartman AN, Newcomb PA, Potter JD, Mandelson MT, Upton MP, Zhu L, Wurscher MA, Markar KW. CIMP is common for right-sided colon sessile serrated polyps but not for colorectal adenomas. Poster presented at the American Association for Cancer Research Meeting 2011. Burnett-Hartman AN, Newcomb PA, Mandelson MT, Wurscher MA, Markar KW. Differences in risk factors for serrated colorectal polyps according to CpG Island Methylator Phenotype (CIMP) status. Oral presentation at the Congress of Epidemiology Meeting, 2011. Burnett-Hartman AN, Newcomb PA, Adams SV. Temporal trends in endoscopy from 1999-2008 in young adults with and without a family history of colorectal cancer. Poster presented at the American Society of Preventive Oncology Meeting, 2012. Burnett-Hartman AN, Newcomb PA. Pathways to colorectal cancer: sessile serrated polyps. Invited speaker at the Cancer Intervention and Surveillance Modeling Network (CISNET) Meeting, 2012. Burnett-Hartman AN, Newcomb PA, Zhu L, Wurscher MA, Upton MP, Potter JD, Markar KW. BRAF mutation is associated with large, proximal sessile serrated polyps, but not with adenomas. Poster presented at the American Association for Cancer Research Meeting, 2012. Burnett-Hartman AN, Phipps AI, Passarelli MN, Grady WM, Upton MP, Zhu L, Newcomb PA. The association between endoscopy and colorectal sessile serrated polyps. Poster presented at Digestive Diseases Week, 2012. Burnett-Hartman AN, Newcomb PA, Veenstra DL. The impact of colonoscopy screening guidelines that incorporate precursors in the serrated pathway: a cost-effectiveness analysis. Oral presentation at the American Society of Preventive Oncology Meeting, 2013. Burnett-Hartman AN, Newcomb PA, Hutter CM, Peters U, Zhu L, Upton MP, Makar KW. The association between colorectal cancer susceptibility loci and colorectal conventional adenomas and serrated polyps. Poster presentation at the Society for Epidemiologic Research, 2013. CURRENT AND RECENTLY COMPLETED RESEARCH SUPPORT NIH U01 CA163304 (Feng/Barlow) 09/20/11 – 09/19/16 PROSPR Statistical Coordinating Center (PSCC) The goal of the PROSPR Statistical Coordinating Center (PPSCC) is to coordinate the research of PROSPR Research Centers (PRCs) to achieve PROSPR’s mission of evaluating and improving the cancer screening process (recruitment, screening, diagnosis, and referral for treatment). NIH KL2 TR000421-07 (Disis) 07/01/12 – 06/30/16 KL2 Research Scholar, National Center for Research Resources, National Institutes of Health Multidisciplinary Clinical Research Career Development Program, Institute of Translational Health Sciences, University of Washington This career development award will support Dr. Burnett-Hartman to build a research program centered on the colorectal cancer prevention. NIH R03 CA153323 (Newcomb) 08/01/10 – 6/30/12 GWAS Identified Colorectal Cancer SNPs and Colorectal Polyp Risk This project, an ancillary study to R01 CA097325, seeks determine the risk of adenomas and serrated polyps associated with 10 specific polymorphisms identified through GWAS, and the genes or regions of the genome that house these loci using a tagSNP approach. NIH R03 CA137752 (Newcomb) 08/01/09 – 06/30/12 Human Papillomavirus Association with Subsets of Colorectal Cancer The overall goal of this project is to conduct a case-control study of localized colorectal cancer to determine the association between high-risk HPV infection and tumor and personal characteristics. NIH R01 CA097325 (Newcomb) 05/17/04 – 04/30/12 Colon Cancer Pathways: Hyperplastic Polyps and Adenomas The primary purpose of this case-control study is to describe the epidemiology of serrated polyps and compare the biological and genetic features of these lesions with adenomas and “clean colon” controls at a large health maintenance organization.