Download Surgical Oncology

Systemic Organ Regulation
Surgical Oncology
1. Staffs and Students
Professor:
Kenichi SUGIHARA
Junior Associate Professor: Satoru IIDA, Mikito INOKUCHI
Assistant Professor: Takanobu SATO, Toshiaki ISHIKAWA,
Tsuyoshi NAKAGAWA, Keiji KATO,
Takatoshi MATSUYAMA, Kazuo MOTOYAMA,
Makoto NAGAHARA, Satoshi OKAZAKI
Professor: Kazuyuki KOJIMA (Minimally invasive surgery center)
Associate Professor: Hiroyuki UETAKE (Translational oncology)
Associate Professor: Hirotoshi KOBAYASHI (Minimally invasive surgery center)
Assistant Professor: Megumi ISHIGURO (Translational oncology)
Graduate Student: Yasushi TAKATSUNO, Ken HINOUE,
Hirofumi SUGITA, Goshi ODA,
Akifumi KIKUCHI, Yoshitake FUJIMORI,
Shinichi YAMAUCHI, Kohji MIYAZAKI,
Hideaki MURASE, Hitoshi SUGIMOTO,
Nobuko TAMURA, Toshiyuki ISHIBA,
Norihito OGAWA, Taiki MASUDA,
Mai KASAHARA, Toshimitsu YANAKA,
Ayako KAMIYA, Yuya SATO,
Masatoshi NAKAGAWA, Hironobu BABA
2. Purpose of Education
Main objective of surgical oncology in the graduate course is to provide students with opportunity to study oncology in
order to become the well-rounded surgeon who has international and scientific feelings.
3. Research Subjects
1)Role of Cox-2 and VEGF in growth of solid tumor and angiogenesis
2)Identification of predictive factors for chemo-responsiveness and prognosis in cancer by molecular biological
technique.
4. Clinical Services
Surgical oncology clinic performs less invasive operation for cancer of stomach, colon and rectum, and breast with new
devices including laparoscope, thereby allowing physiological and neurological functions to be preserved. Moreover,
treatment with chemotherapeutic agents for cancer is also conducted.
5. Publications
Original Articles
1. Kotake K, Honjyo S, Sugihara K, Hashiguchi Y, Kato T, Kodaira S, Muto T, Koyama Y.　Number of lymph nodes
retrieved is an important determinant of survival of patients with stage II and stage III colorectal cancer. Jpn J Clin
Oncol 2012;42(1):29-35
2. Masaki T, Sugihara K, Nakajima A, Muto T. Nationwide survey on adult type chronic intestinal pseudo-obstruction
in surgical institutions in Japan. Surg Today 2012;42(3):264-271
3. Khamas A, Ishikawa T, Shimokawa K, Mogushi K, Iida S, Ishiguro M, Mizushima H, Tanaka H, Uetake H, Sugihara
K. Screening for epigenetically masked genes in colorectal cancer using 5-Axa-2’-deoxycytidine, microarray and
gene expression profile. Cancer Genomics & Proteomics 2012;9(2):67-75
4. Mochizuki I, Takiuchi H, Nakamoto Y, Kinugasa Y, Takagane A, Endo T, Shinomaki H, Takai Y, Takahashi Y,
Mochizuki H, Kotake K, Kameoka S, Takahashi K, Watanabe T, Watanabe M, Boku N, Tomita N, Matsubara Y,
Sugihara K. Safety of UFT/LV and S-1 as adjuvant therapy for stage III colon cancer in phase III trial: ACTS-CC
trial. Br J Cancer 2012;106(7):1268-1273
5. Ishiguro M, Watanabe T, Yamaguchi K, Satoh T, Ito H, Seriu T, Sakata Y, Sugihara K. A Japanese post-marketing
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Systemic Organ Regulation
surveillance of cetuximab(Erbitux) in patients with metastatic colorectal cancer. Jpn J Clin Oncol 2012;42(4):287-294
6. Ueno H, Mochizuki H, Shirouzu K, Kusumi T, Yamada K, Ikegami M, Kawachi H, Kameoka S, Ohkura Y, Masaki T,
Kushima R, Takahashi K, Ajioka Y, Hase K, Ochiai A, Wada R, Iwaya K, Nakamura T, Sugihara K. Multicenter
study for optimal categorization of extramural tumor deposits for colorectal cancer staging. Ann Surg
2012;255(4):739-746
7. West N, Kobayashi H, Takahashi K, Perrakis A, Weber K, Hochenberger W, Sugihara K, Quirke P. Understanding
optimalcolonic cancer surgery: comparison of Japanese D3 resection and European complete mesocolic excision with
central vascular ligation. J Clin Oncol 2012;30(15):1763-1769
8. Akagi Y, Shirouzu K, Fujita S, Ueno H, Takii Y, Komori K, Ito M, Sugihara K. Predicting oncologic outcomes by
stratifying mesorectal excision in patients with pT3 rectal cancer: a Japanese multi-institutional study. Int J Cancer
2012;131(5):1220-1227
9. Ito N, Ishiguro M, Uno M, Kato S, Shimizu S, Obata R, Tanaka M, Tokunaga K, Nagano M, Sugihara K, Kazuma K.
Prospective longitudinal evaluation of quality of life in patients with permanent colostomy after curative resection
for rectal cancer: a preliminary study. J World Ostomy Continence Nurs 2012;39(2):172-177
10. Khamas A,Ishikawa T,Mogushi K,Iida S,Ishiguro M,Tanaka H, Uetake H, Sugihara K. Genome-wide screening for
methylation-silenced genes in colorectal cancer. Int J Oncol 2012;41(2):490-496
11. Sugihara K, Ohtsu A, Shimada Y, Mizunuma N, Lee PH, de Gramont A, Goldberg RM, Rothenberg ML, Andre T,
Brienza S, Gomi K. Safty analysis of FOLFOX4 treatment in colorectal cancer patients: A comparison between two
Asian studies and four Western Studies.
Clin Colorectal Cancer 2012;11(2):127-136
12. Watanabe T, Itabashi M, Shimada Y, Tanaka S, Ito Y, Ajioka Y, Hamaguchi T, Hyodo I, Igarashi M, Ishida H,
Ishiguro M, Kanemitsu Y, Kokudo N, Muro K, Ochiai A, Ohkura Y, Saito Y, Sakai Y, Ueno H, Yoshino T, Fujimori
T, Koinuma N, Morita T, Nishimura G, Sakata Y, Takahashi K, Takiuchi H, Tsuruta O, Yamaguchi T, Yoshida M,
Yamaguchi N, Kotake K, Sugihara K, JSCCR. Japanese society for cancer of the colon and recum (JSCCR) guidelines
2010 for the treatment of colorectal cancer. Int J Clin Oncol 2012;17(1):1-29
13. Saida Y, Fujimori T, Tanaka H, Fujimori Y, Kimura R, Ueda H, Ichikawa K, Tomita S, Nagata H, Kubota K, Tsubaki
M, Kato H, Yao T, Sugai T, Sugihara K, Ohkura Y, Imura J. Clinicopathological features of serrated adenocarcinoma
defined by Mäkinen in dukes' B colorectal carcinoma. Pathobiology 2012;79(4):169-218
14. Ueno H, Mochizuki, Akagi Y, Kusumi T, Yamada K, Ikegami M, Kawachi H, Kameoka S, Ohkura Y, Masaki T,
Kushima R, Takahashi K, Ajioka Y, Hase K, Ochiai A, Wada R, Iwaya K, Shimazaki H, Nakamura T, Sugihara K.
Optimal Colorectal Cancer Staging Criteria in TNM Classification. J Clin Oncol 2012;30(13):1519-1526
15. Fujimori Y, Inokuchi M, Takagi Y, Kato K, Kojima K, Sugihara K. Prognostic value of RKIP and p-ERK in Gastric
Cancer. J Experimental Clin Can Res 2012;31:30
16. Kanemitu Y, Komori K, Ishiguro S, Watanabe T, Sugihara K. The relationship of lymph node evaluation and
colorectal cancer survival after curative resection: a multi-institutional study. Ann Surg Oncol 2012;19:2169-2177
17. Hashiguchi Y, Hase K, Ueno H, Shinto E, Mochizuki H, Yamamoto J, Sugihara K. Evaluation of seventh edition of
the tumor, node, metastasis (TNM) classification for colon cancer in two nationwide registries of the United States
and Japan. Colorectal Disease 2012;14:1065-1075
18. Kobayashi H, Higuchi T, Uetake H, Iida S, Ishikawa T, Sugihara K. Laparoscopic-assisted colectomy in a patient
with colon cancer after percutaneous endoscopic gastrostomy. World J Surg Oncol 2012;10(1):116
19. Uetake H,Tanaka S, Ishikawa T, Sugihara K, Arii S. Fate of metastatic foci after chemotherapy and usefulness of
contrast-enhanced intraoperative ultrasonography to detect minute hepatic lesions. J Hepatobiliary, Pancreat Sci
2012;19:509-514
20. Ishiguro M, Mochizuki H, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Kanemitu Y, Ueno H,
Ishikawa T, Uetake H, Matsui S, Teramukai S, Sugihara K. Study protocol of the SACURA trial: a randomized
phase III trial of efficacy and safty of UFT as adjuvant chemotherapy for stage II colon cancer. BMC Cancer 2012;
12:281
21. Kihara K, Fujii Y, Masuda H, Saito K, Koga F, Matsuoka Y, Numao N, Kojima K. New three-dimensional headmounted display system, TMDU-S-3D system, for minimally invasive surgery application: Procedures for gasless
sigle-port radical nephrectomy. Int J Urol 2012;19(9):886-889
22. Kudo A, Akashi T, Kumagai J, Ban D, Inokuchi M, Kojima K, Kawano T, Tanaka S, Arii S. The Importance of
Clinical Information in Patients with Gastroenteropancreatic Neuroendocrine Tumor. Hepatogastroenterology.
2012;59(120)2450-24523
23. Kudo A, Ban D, Akashi T, Kumagai J, Aihara A, Inokuchi M, Kojima K, Kawano T, Tanaka S, Arii S. Prognoses of
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GEP-Nets with Undetermined Malignant Potentials of their Primary Sites. Hepatogastroenterology. 2012;59(118)16821686
24. Okamoto N, Kawachi H, Yoshida T, Kitagaki K, Sekine M, Kojima K, Kawano T, Eishi Y. "Crawling-type"
adenocarcinoma of the stomach: a disstinct entity preceding poorly differentiated adenocarcinoma. Gastric Cancer.
2012; 16(2):220-232
25. Sato T, Iwasaki A, Iwama T, Kawai S, Nakagawa T, Sugihara K. A rare case of exten sive ductal carcinoma in situ
of the breast with seretory features. Rare Tumor2012; 4:e52:169-171
26. Inokuchi M, Kojima K, Yamada H, Kato K, Hayashi M, Motoyama K, Sugihara K. Long-term outcomes of Roux-en-Y
and Billroth-I reconstruction after laparoscopic distal gastrectomy. Gastric Cancer 2012;16(1):67-73
27. Sugihara K, Ohtsu A, Shimada Y, Mizunuma N, Gomi k, Lee PH, de Gramont, Rothenberg ML, Andre T, Brienza S,
Goldberg RM. Analysis of neurosensory adverse events induced by FOLFOX4 teatment in colorectal cancer
patients: a comparison between two Asian and four Western studies. Cancer Med 2012;1:198-206
28. Kobayashi H, Higuchi T, Uetake H, Iida S, Ishikawa T, Ishiguro M, Sugihara K. Resection with en block removal of
regional lymph node after endoscopic resection of T1 colorectal cancer. Ann Surg Oncol 2012;19(13):2471-2477
29. Kinugasa Y, Arakawa T, Abe H, Abe S, Cho BH, Murakami G, Sugihara K. Anococcygeal Raphe Revisited: A
Histological Study Using Mid-Term Human Fetuses and Elderly Cadavers. Yonsei Med J 2012;53(4):849-855
30. Fujii S, Yamamoto S, Ito M, Yamaguchi S, Sakamoto K, Kinugasa Y, Kokuba Y, Okuda J, Yoshimura K, Watanabe
M. Shot-term outcomes of laparoscopic inters phincteric resection from a phaseⅡtrial to evaluate laparoscopic
surgery for stage 0/ rectal cancer: Japan Society of Laparoscopic Colorectal Surgery Lap RC. Surg Endos
2012;26:3067-3076
31. Fujita S, Akasu T, Mizusawa J, Saito N, Kinugasa Y, Ohue M, Fujii S, Shiozawa M, Yamaguchi T, Moriya Y.
Postoperative morbidity and mortality after mesorectal excision with and without lateral lymph node dissection for
clinical stageⅡor stage Ⅲlower rectal cancer(JCOG0212): results from a multicentre, randomized controlled, noninferiority trial. Lancet Oncol 2012;13:616-621
32. Oda G, Sato T, Ishikawa T, Kawachi H, Nakagawa T, Kuwayama T, Ishiguro M, Iida S, Uetake H, Sugihara K.
Significance of stromal decorin expression during the progression of breast cancer. Oncol Rep 2012;28(6):2003-2008
33. Iida S, Kato K, Ishiguro M, Matsuyama T, Ishikawa T, Kobayashi H, Higuchi T, Uetake H, Enomoto M, Sugihara
K.PIK3CA mutation and methylation influences the outcome of colorectal cancer. Oncol Lett 2012;3(3):565-570
34. Grimminger P, Maus M, Schneider P, Metzger R, Holscher A, Sugita H, Danenberg P, Alakus H, Brabender J.
Glutathione S-transferase PI(GST-PI) mRNA expression and DNA methylation is involved in the pathogenesis and
prognpsis of NSCLC. Lung Cancer 2012;78(1):87-91
35. Azzoli C, Drilon A, Sugita H, Sima C, Huang E, Danenberg P, Kris M, Rusch V. Prospective study of tumor
suppressor gene(TSG) methylation as a prognostic biomarker in surgically resected non-small cell lung
cancer(NSCLC). J Clin Oncol 2012;30 in print
Review Articles
1. Sugihara K,Uetake H. The rapeutic strategies for hepatic metastasis of colorectal cancer:overview. J Hepatobiliary
Pancreat Sci 2012;19(5)523-527
Books
1. Kinugasa Y, Moriya Y. Surgical anatomy in intersphincteric resection. Intersphincteric Resection for Low Rectal
Tumors. Rudolf Schiessel. Peter Metzgered. Austria: Springer Wien New York 2012:57-63
2. Kobayashi K, Sugihara K. Surveillance and Characteristics of Recurrence After Curative Resection for Colorectal
Cancer. Contemporary Issues in Colorectal Syrgical Practice. Yik-Hong Ho ed.　INTECH 2012:89-112　3. Kojima K, Sugihara K, Sohn TS, Lee JH.Dissection of lymph nodes around the common hepatic artery (Nos.7,8a,9
lymph nodes). Laparoscopic Gastrectomy for Cancer Kitano S Yang HK ed. INTECH 2012：79 – 80
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