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Download 3116-3127 May 15, 2014
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Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia by Mark T. S. Williams, Yasar Yousafzai, Charlotte Cox, Allison Blair, Ruaidhrí Carmody, Shuji Sai, Karen E. Chapman, Rachel McAndrew, Angela Thomas, Alison Spence, Brenda Gibson, Gerard J. Graham, and Christina Halsey Blood Volume 123(20):3116-3127 May 15, 2014 ©2014 by American Society of Hematology IL-15 and IL-15 receptor expression by pre-B ALL cells and correlation with CNS infiltration. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology Pre-B ALL primary cells and SD-1 cells show increased growth in the presence of IL-15. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology IL-15 has no effect on apoptosis in SD-1 cells. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology IL-15 promotes growth of SD-1 cells under low-serum conditions, which is independent of apoptosis. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology IL-15 is not directly chemotactic but induces expression of molecules associated with leukocyte trafficking. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology STAT5 and ERK1/2 signaling pathways are activated by IL-15 in SD-1 cells. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology IL-15–induced proliferation of SD-1 cells is mediated via the MEK/ERK signaling pathway. Mark T. S. Williams et al. Blood 2014;123:3116-3127 ©2014 by American Society of Hematology
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