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Supplementary Table 2: Gene expression in Ha-ras-mutated mouse liver tumors
versus normal liver
Accession no
Gene
Metabolic enzymes
Carbohydrate metabolism
BG793658
aldolase 1A
AW547988
brain glycogen phosphorylase
BC027438
galactose-4-epimerase, UDP
BB777344
glucosamine-6-phosphate deaminase
BC012247
dicarbonyl L-xylulose reductase
Lipid metabolism
NM_009286
sulfotransferase, hydroxysteroid preferring 2
NM_009128
stearoyl-Coenzyme A desaturase 2
NM_134066
aldo-keto reductase family 1C18
BC002008
fatty acid binding protein 5, epidermal
NM_011994
ATP-binding cassette D2
NM_021486
beta-carotene 15, 15'-dioxygenase 1
NM_007809
cytochrome P450 17A1
NM_024406
fatty acid binding protein 4, adipocyte
NM_013490
choline kinase
BC018263
cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like
AK014742
lanosterol synthase
BG066773
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6
NM_007702
cell death-inducing DNA fragmentation factor, alpha subunit-like
effector A
BC014865
leukotriene B4 12-hydroxydehydrogenase
BC010332
phosphatidic acid phosphatase type 2c
BB430611
fatty acid desaturase 2
NM_023523
peroxisomal trans-2-enoyl-CoA reductase
NM_054094
butyryl Coenzyme A synthetase 1
NM_024264
cytochrome P450, family 27, subfamily a, polypeptide 1
BC026757
hydroxysteroid dehydrogenase-2, delta<5>-3-beta
BC016251
choline phosphotransferase 1
NM_008280
lipase, hepatic
NM_007825
cytochrome P450 7B1
NM_007824
cytochrome P450 7A1
BC010973
cytochrome P450 8B1
Amino acid metabolism, urea cycle
BC004827
phosphoserine aminotransferase 1
NM_133900
phosphoserine phosphatase
AA561726
3-phosphoglycerate dehydrogenase
NM_133768
argininosuccinate lyase
BC008119
ornithine aminotransferase
BC012637
kynurenine aminotransferase II
U09114
glutamate-ammonia ligase (glutamine synthase)
NM_011172
proline dehydrogenase
Nucleotide metabolism
AK013765
endothelial cell growth factor 1 (platelet-derived)
AW490997
dihydropyrimidinase
Xenobiotic metabolism
BB819674
ATP-binding cassette B1A
BC010593
cytochrome P450 2D9
NM_008184
glutathione S-transferase, mu 6
NM_019878
sulfotransferase family 1B1
BF783609
cytochrome P450, 2J5
NM_009993
cytochrome P450 1A2
NM_010001
cytochrome P450 2C37
AI256046
Mus musculus, similar to cytochrome P450 IIC
AK006371
nicotinamide N-methyltransferase
Protein processing
NM_009258
serine protease inhibitor, Kazal type 3
NM_011414
secretory leukocyte protease inhibitor
BC010197
carboxypeptidase E
NM_007585
annexin A2
NM_024169
FK506 binding protein 11
NM_022433
sirtuin 3
NM_023341
chaperone, ABC1 activity of bc1 complex like (S. pombe)
Nucleic acid processing, nuclear proteins
AV303002
nucleoporin like 1
AF316014
deoxynucleotidyltransferase, terminal
U43884
inhibitor of DNA binding 1
Gene Symbol
log2 ratios
Aldo1
Pygb
Gale
Gnpi
Dcxr
2.69; 2.30
2.47
2.14
-2.36
-2.92
Sth2
Scd2
Akr1c18
Fabp5
d2
Bcdo1
Cyp17a1
Fabp4
Chk
CRAD-L
Lss
B4galt6
Cidea
9.04
8.48; 4.97
8.16
7.01; 3.64
5.24
4.63
4.35
4.14; 3.29
3.18
2.82
2.66; 2.64
2.62; 2.35
2.40
Ltb4dh
Ppap2c
Fads2
Pecr
Bucs1
Cyp27a1
Hsd3b2
Chpt1
Lipc
Cyp7b1
Cyp7a1
Cyp8b1
2.32
2.07
2.04
-2.11
-2.15
-2.60
-2.91
-2.95; -2.49
-3.33
-4.39
-4.75; -3.23
-5.20
Psat1
Psph
Phgdh
Asl
Oat
Kat2
Glul
Prodh
6.17; 5.50
4.39
3.58; 2.03
-2.06
-2.85
-3.97
-4.41
-4.73
Ecgf1
Dpys
-2.18
-2.63; -2.74
Abcb1a
Cyp2d9
Gstm6
Sult1b1
Cyp2j5
Cyp1a2
Cyp2c37
--Nnmt
2.08
-2.03
-2.13
-2.15
-2.30
-3.56
-3.57
-3.98
-4.73
Spink3
Slpi
Cpe
Anxa2
Fkbp11
Sirt3
Cabc1
8.45
6.10
5.89
3.57
2.28
-2.13
-3.19
Nupl1
Dntt
Idb1
3.09
2.94
2.46
AF090696
CUG triplet repeat,RNA binding protein 2
BM899344
synaptonemal complex protein 3
BC005569
ribonuclease, RNase A family 4
NM_007447
angiogenin
Other metabolic enzymes
BC004831
spermine oxidase
BC020001
aldehyde dehydrogenase 1B1
AK017155
agmatine ureohydrolase (agmatinase)
BC026584
alcohol dehydrogenase 8
AB041034
NADPH oxidase 4
AF117613
heme binding protein 1
M63244
aminolevulinic acid synthase 2, erythroid
NM_011996
alcohol dehydrogenase 4 (class II), pi polypeptide
Regulatory proteins
Receptors
NM_010742
lymphocyte antigen 6 complex, locus D
AF342896
killer cell lectin-like receptor B1D
NM_007974
coagulation factor II (thrombin) receptor-like 1
NM_008526
killer cell lectin-like receptor B1B
NM_020043
neighbor of Punc E11
NM_013749
tumor necrosis factor receptor superfamily 12a
AF316985
toll-like receptor 1
BC020004
G protein-coupled receptor, family C5B
BB234940
discoidin domain receptor family 1
NM_007657
CD9 antigen
BG793483
transforming growth factor beta receptor II
NM_007471
amyloid beta (A4) precursor protein
NM_011906
transmembrane domain protein regulated in adipocytes
M33324
growth hormone receptor
BM224327
Fc receptor, IgG, low affinity IIb
AK018789
neurotrophic tyrosine kinase, receptor, type 2
NM_016847
arginine vasopressin receptor 1A
AF009328
nuclear receptor subfamily 1I3 (CAR)
Cell signalling
BC025461
transmembrane 4 superfamily 3
NM_010915
nerve growth factor, alpha
BC020038
endothelial cell-specific molecule 1
NM_023517
tumor necrosis factor (ligand) superfamily,13
M57525
interleukin 1 receptor antagonist
NM_008341
insulin-like growth factor binding protein 1
AF068182
B-cell linker
NM_026268
dual specificity phosphatase 6
AV239587
bone morphogenetic protein 2
NM_025658
membrane-spanning 4-domains A4D
NM_008340
insulin-like growth factor binding protein, acid labile subunit
Small GTPase-mediated signal transduction
AI503490
ras homolog gene family, member C
BE688720
Mus musculus, similar to RAS guanyl releasing protein 2
BG071632
HIV-1 Rev binding protein
BM230485
RAB3D
AF327929
RAB34
BG067878
ADP-ribosylation factor GTPase activating protein 3
Calcium metabolism, calcium signalling
AY061807
calmodulin-like 4
BC021916
S100 calcium binding protein A11 (calizzarin)
Transcriptional regulators
AV025472
core promoter element binding protein
BF453911
cyclin D binding myb-like transcription factor 1
AW049660
nuclear factor I/X
AW412521
v-maf musculoaponeurotic fibrosarcoma oncogene family B (avian)
Cell division, differentiation, apoptosis
NM_009052
reduced expression 3
AF059567
cyclin-dependent kinase inhibitor 2B (p15)
NM_007570
B-cell translocation gene 2
BC022135
pregnancy-induced growth inhibitor
NM_009770
B-cell translocation gene 3
BI078799
myeloid-associated differentiation marker
BC010403
presenilin 2
NM_009690
CD5 antigen-like
Structural proteins
Cytosceleton
BC003475
tubulin, beta 2
NM_019682
dynein, cytoplasmic, light chain 1
Cugbp2
Sycp3
Rnase4
Ang
-2.64
-2.77
-3.31
-5.34
Smox-pending
Aldh1b1
Agmat
Adh8-pending
Nox4
Hebp1
Alas2
Adh4
2.45
2.20
-2.13
-2.18
-2.39; -3.87
-2.66
-3.14
-3.24
Ly6d
Klrb1d
F2rl1
Klrb1b
Nope
Tnfrsf12a
Tlr1
Gprc5b
Ddr1
Cd9
Tgfbr2
App
Tpra40-pending
Ghr
Fcgr2b
Ntrk2
Avpr1a
Nr1i3
9.78
5.47; 4.11; 3.95
5.25
4.78
4.66; 3.95
4.42; 3.99
3.63
3.54
2.92
2.52
2.32
2.22
2.06
-2.12; -2.06
-2.25
-2.51
-2.97
-3.18
Tm4sf3
Ngfa
Esm1
Tnfsf13
Il1rn
Igfbp1
Blnk
Dusp6
Bmp2
Ms4a4d
Igfals
10.66
6.69; 6.29
5.96
5.56
4.31
4.15
2.63
2.16
-2.08
-2.55
-2.77
Rhoc
--Hrb
Rab3d
Rab34
Arfgap3
3.64; 3.14
3.01; 3.37
3.18; 2.72
2.79
2.37
2.06
Calml4
S100a11
5.90
3.66
Copeb
Dmtf1
Nfix
Mafb
2.32
-2.00
-2.15
-2.37
Rex3
Cdkn2b
Btg2
Okl38-pending
Btg3
Myadm
Psen2
Cd5l
8.86
4.45
3.09
2.65
2.35
2.24
-2.02
-3.12
Tubb2
Dnclc1
3.30
2.98; 2.85; 2.72
AV224521
gelsolin
Extracellular matrix, cell adhesion
BC004638
secreted acidic cysteine rich glycoprotein
NM_010917
nidogen 1
BF583242
activated leukocyte cell adhesion molecule
AK006809
SPARC related modular calcium binding 2
AF126834
periplakin
BE381767
camello-like 2
NM_023455
camello-like 4
NM_023160
camello-like 1
NM_007899
extracellular matrix protein
NM_007833
decorin
Others
Transport
NM_007423
alpha fetoprotein
BC010769
apolipoprotein A-IV
NM_016900
caveolin 2
BC006732
cytochrome B561
NM_018816
apolipoprotein M
M30697
ATP-binding cassette B1A
BC026948
SEC14-like 4 (S. cerevisiae)
BC022130
solute carrier family 26A1
NM_021022
ATP-binding cassette B11
AI593492
ATPpase VI11C
NM_021370
amiloride-sensitive cation channel 5, intestinal
Complement activation, Immune system
NM_010740
complement component 1, q subcomponent, receptor 1
NM_007796
cytotoxic T lymphocyte-associated protein 2a
NM_016704
complement component 6
BC022129
complement 8b
Miscellaneous
NM_023123
H19 fetal liver mRNA
NM_008935
prominin 1
NM_032002
neuregulin 4
BC011152
golgi phosphoprotein 2
BM935811
Mus musculus integrin alpha 6 mRNA partial cds
NM_011979
vanin 3
NM_133662
immediate early response 3
AB034693
endomucin
AK004598
ALEX3 protein
NM_013562
interferon-related developmental regulator 1
BC007478
WW domain binding protein 5
C76322
transgelin 2
NM_009636
AE binding protein 1
BB221402
fat specific gene 27
BC027197
sulfite oxidase
NM_007792
cysteine and glycine-rich protein 2
BC020489
hypothetical protein LOC22367
BC025145
hypothetical protein MGC36851
BF580567
host cell factor C1 regulator 1 (XPO1-dependent)
NM_019999
brain protein 17
BB464434
selenoprotein W, muscle 1
BC025105
hypothetical protein A530061A11
NM_010702
leukocyte cell-derived chemotaxin 2
NM_007995
ficolin A
NM_016751
C-type lectin, superfamily 13
Unknown
AK017241
RIKEN cDNA 5330417C22 gene
BC021795
RIKEN cDNA 1810023F06 gene
AK010477
RIKEN cDNA 2410012M21 gene
BC026654
cDNA sequence BC018222
NM_138685
RIKEN cDNA 9230106L14 gene
AK018605
RIKEN cDNA 4631408O11 gene
BG297038
--NM_025703
RIKEN cDNA 3930402F23 gene
AK007421
RIKEN cDNA 1300003D03 gene
AW111083
Mus musculus transcribed sequence
NM_138587
DNA segment, Chr 6, Wayne State University 176, expressed
NM_026473
RIKEN cDNA 2310057H16 gene
NM_026167
RIKEN cDNA 1200009K10 gene
NM_133770
RIKEN cDNA 0610012P18 gene
NM_026179
RIKEN cDNA 1300003D03 gene
BG963358
RIKEN cDNA 5730445F03 gene
Gsn
-2.15
Sparc
Nid1
Alcam
Smoc2
Ppl
Cml2
Cml4
Cml1
Ecm1
Dcn
5.54; 3.62
4.32; 2.68
2.77; 2.26
2.09
2.08
-2.08; -2.51; -2.10
-2.34
-3.38
-3.66
-3.92
Afp
Apoa4
Cav2
Cyb561
Apom
Abcb1a
Sec14l4
Slc26a1
Abcb11
Atp11c
Accn5
10.85; 9.62; 8.46
4.26; 2.85
3.08
2.52
2.27; 2.02
2.09
-2.03
-2.03
-2.60
-2.61
-3.08
C1qr1
Ctla2a
C6
C8b
3.67
2.10
-2.57
-3.05
H19
Prom1
Nrg4
Golph2
--Vnn3
Ier3
Emcn-pending
Alex3-pending
Ifrd1
Wbp5
Tagln2
Aebp1
Fsp27
Suox
Csrp2
LOC223672
MGC36851
Hcfc1r1
Brp17
Sepw1
A530061A11
Lect2
Fcna
Clecsf13
6.69
3.84
3.17
3.06
3.00
2.96
2.65
2.37
2.35
2.35
2.32
2.16
2.10
2.02
-2.24
-2.30
-2.32
-2.40
-2.51
-2.61
-2.71
-2.92
-3.04
-3.45
-4.47
5330417C22Rik
1810023F06Rik
2410012M21Rik
BC018222
9230106L14Rik
4631408O11Rik
--3930402F23Rik
1300003D03Rik
--D6Wsu176e
2310057H16Rik
1200009K10Rik
0610012P18Rik
1300003D03Rik
5730445F03Rik
6.31
4.88
4.41
4.35
4.33
3.99
3.79
3.66
3.35
3.34
3.15
3.04
2.65
2.62
2.60
2.50
NM_133929
BC026655
NM_133825
BC021951
AB056443
BI649826
NM_133775
BC019471
NM_028785
BC020021
AA215276
AK009207
NM_133960
BC021842
BC010592
NM_134147
RIKEN cDNA E330009J07 gene
RIKEN cDNA 2310045A20 gene
DNA segment, Chr 1, ERATO Doi 622, expressed
RIKEN cDNA 2010003K11 gene
hypothetical protein D630002G06
RIKEN cDNA 2310008N12 gene
RIKEN cDNA 9230117N10 gene
RIKEN cDNA 1810055G02 gene
RIKEN cDNA 1200017A24 gene
RIKEN cDNA 2810439F02 gene
Mus musculus transcribed sequences
RIKEN cDNA 2310007H09 gene
RIKEN cDNA 9130231C15 gene
RIKEN cDNA E430021N18 gene
RIKEN cDNA 0610025L15 gene
RIKEN cDNA D930010J01 gene
E330009J07Rik
2310045A20Rik
D1Ertd622e
2010003K11Rik
D630002G06
2310008N12Rik
9230117N10Rik
1810055G02Rik
1200017A24Rik
2810439F02Rik
--2310007H09Rik
9130231C15Rik
E430021N18Rik
0610025L15Rik
D930010J01Rik
2.48
2.44
2.43; 2.38
2.25
2.24
2.22
2.21
2.08
-2.10
-2.24
-2.30
-2.36
-2.71
-2.77
-3.19
-3.41
If genes are represented by more than one probe set on the chip, their individual log2 ratios
are shown.
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