Survey
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the work of artificial intelligence, which forms the content of this project
Supplementary Table 2: Gene expression in Ha-ras-mutated mouse liver tumors versus normal liver Accession no Gene Metabolic enzymes Carbohydrate metabolism BG793658 aldolase 1A AW547988 brain glycogen phosphorylase BC027438 galactose-4-epimerase, UDP BB777344 glucosamine-6-phosphate deaminase BC012247 dicarbonyl L-xylulose reductase Lipid metabolism NM_009286 sulfotransferase, hydroxysteroid preferring 2 NM_009128 stearoyl-Coenzyme A desaturase 2 NM_134066 aldo-keto reductase family 1C18 BC002008 fatty acid binding protein 5, epidermal NM_011994 ATP-binding cassette D2 NM_021486 beta-carotene 15, 15'-dioxygenase 1 NM_007809 cytochrome P450 17A1 NM_024406 fatty acid binding protein 4, adipocyte NM_013490 choline kinase BC018263 cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like AK014742 lanosterol synthase BG066773 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 NM_007702 cell death-inducing DNA fragmentation factor, alpha subunit-like effector A BC014865 leukotriene B4 12-hydroxydehydrogenase BC010332 phosphatidic acid phosphatase type 2c BB430611 fatty acid desaturase 2 NM_023523 peroxisomal trans-2-enoyl-CoA reductase NM_054094 butyryl Coenzyme A synthetase 1 NM_024264 cytochrome P450, family 27, subfamily a, polypeptide 1 BC026757 hydroxysteroid dehydrogenase-2, delta<5>-3-beta BC016251 choline phosphotransferase 1 NM_008280 lipase, hepatic NM_007825 cytochrome P450 7B1 NM_007824 cytochrome P450 7A1 BC010973 cytochrome P450 8B1 Amino acid metabolism, urea cycle BC004827 phosphoserine aminotransferase 1 NM_133900 phosphoserine phosphatase AA561726 3-phosphoglycerate dehydrogenase NM_133768 argininosuccinate lyase BC008119 ornithine aminotransferase BC012637 kynurenine aminotransferase II U09114 glutamate-ammonia ligase (glutamine synthase) NM_011172 proline dehydrogenase Nucleotide metabolism AK013765 endothelial cell growth factor 1 (platelet-derived) AW490997 dihydropyrimidinase Xenobiotic metabolism BB819674 ATP-binding cassette B1A BC010593 cytochrome P450 2D9 NM_008184 glutathione S-transferase, mu 6 NM_019878 sulfotransferase family 1B1 BF783609 cytochrome P450, 2J5 NM_009993 cytochrome P450 1A2 NM_010001 cytochrome P450 2C37 AI256046 Mus musculus, similar to cytochrome P450 IIC AK006371 nicotinamide N-methyltransferase Protein processing NM_009258 serine protease inhibitor, Kazal type 3 NM_011414 secretory leukocyte protease inhibitor BC010197 carboxypeptidase E NM_007585 annexin A2 NM_024169 FK506 binding protein 11 NM_022433 sirtuin 3 NM_023341 chaperone, ABC1 activity of bc1 complex like (S. pombe) Nucleic acid processing, nuclear proteins AV303002 nucleoporin like 1 AF316014 deoxynucleotidyltransferase, terminal U43884 inhibitor of DNA binding 1 Gene Symbol log2 ratios Aldo1 Pygb Gale Gnpi Dcxr 2.69; 2.30 2.47 2.14 -2.36 -2.92 Sth2 Scd2 Akr1c18 Fabp5 d2 Bcdo1 Cyp17a1 Fabp4 Chk CRAD-L Lss B4galt6 Cidea 9.04 8.48; 4.97 8.16 7.01; 3.64 5.24 4.63 4.35 4.14; 3.29 3.18 2.82 2.66; 2.64 2.62; 2.35 2.40 Ltb4dh Ppap2c Fads2 Pecr Bucs1 Cyp27a1 Hsd3b2 Chpt1 Lipc Cyp7b1 Cyp7a1 Cyp8b1 2.32 2.07 2.04 -2.11 -2.15 -2.60 -2.91 -2.95; -2.49 -3.33 -4.39 -4.75; -3.23 -5.20 Psat1 Psph Phgdh Asl Oat Kat2 Glul Prodh 6.17; 5.50 4.39 3.58; 2.03 -2.06 -2.85 -3.97 -4.41 -4.73 Ecgf1 Dpys -2.18 -2.63; -2.74 Abcb1a Cyp2d9 Gstm6 Sult1b1 Cyp2j5 Cyp1a2 Cyp2c37 --Nnmt 2.08 -2.03 -2.13 -2.15 -2.30 -3.56 -3.57 -3.98 -4.73 Spink3 Slpi Cpe Anxa2 Fkbp11 Sirt3 Cabc1 8.45 6.10 5.89 3.57 2.28 -2.13 -3.19 Nupl1 Dntt Idb1 3.09 2.94 2.46 AF090696 CUG triplet repeat,RNA binding protein 2 BM899344 synaptonemal complex protein 3 BC005569 ribonuclease, RNase A family 4 NM_007447 angiogenin Other metabolic enzymes BC004831 spermine oxidase BC020001 aldehyde dehydrogenase 1B1 AK017155 agmatine ureohydrolase (agmatinase) BC026584 alcohol dehydrogenase 8 AB041034 NADPH oxidase 4 AF117613 heme binding protein 1 M63244 aminolevulinic acid synthase 2, erythroid NM_011996 alcohol dehydrogenase 4 (class II), pi polypeptide Regulatory proteins Receptors NM_010742 lymphocyte antigen 6 complex, locus D AF342896 killer cell lectin-like receptor B1D NM_007974 coagulation factor II (thrombin) receptor-like 1 NM_008526 killer cell lectin-like receptor B1B NM_020043 neighbor of Punc E11 NM_013749 tumor necrosis factor receptor superfamily 12a AF316985 toll-like receptor 1 BC020004 G protein-coupled receptor, family C5B BB234940 discoidin domain receptor family 1 NM_007657 CD9 antigen BG793483 transforming growth factor beta receptor II NM_007471 amyloid beta (A4) precursor protein NM_011906 transmembrane domain protein regulated in adipocytes M33324 growth hormone receptor BM224327 Fc receptor, IgG, low affinity IIb AK018789 neurotrophic tyrosine kinase, receptor, type 2 NM_016847 arginine vasopressin receptor 1A AF009328 nuclear receptor subfamily 1I3 (CAR) Cell signalling BC025461 transmembrane 4 superfamily 3 NM_010915 nerve growth factor, alpha BC020038 endothelial cell-specific molecule 1 NM_023517 tumor necrosis factor (ligand) superfamily,13 M57525 interleukin 1 receptor antagonist NM_008341 insulin-like growth factor binding protein 1 AF068182 B-cell linker NM_026268 dual specificity phosphatase 6 AV239587 bone morphogenetic protein 2 NM_025658 membrane-spanning 4-domains A4D NM_008340 insulin-like growth factor binding protein, acid labile subunit Small GTPase-mediated signal transduction AI503490 ras homolog gene family, member C BE688720 Mus musculus, similar to RAS guanyl releasing protein 2 BG071632 HIV-1 Rev binding protein BM230485 RAB3D AF327929 RAB34 BG067878 ADP-ribosylation factor GTPase activating protein 3 Calcium metabolism, calcium signalling AY061807 calmodulin-like 4 BC021916 S100 calcium binding protein A11 (calizzarin) Transcriptional regulators AV025472 core promoter element binding protein BF453911 cyclin D binding myb-like transcription factor 1 AW049660 nuclear factor I/X AW412521 v-maf musculoaponeurotic fibrosarcoma oncogene family B (avian) Cell division, differentiation, apoptosis NM_009052 reduced expression 3 AF059567 cyclin-dependent kinase inhibitor 2B (p15) NM_007570 B-cell translocation gene 2 BC022135 pregnancy-induced growth inhibitor NM_009770 B-cell translocation gene 3 BI078799 myeloid-associated differentiation marker BC010403 presenilin 2 NM_009690 CD5 antigen-like Structural proteins Cytosceleton BC003475 tubulin, beta 2 NM_019682 dynein, cytoplasmic, light chain 1 Cugbp2 Sycp3 Rnase4 Ang -2.64 -2.77 -3.31 -5.34 Smox-pending Aldh1b1 Agmat Adh8-pending Nox4 Hebp1 Alas2 Adh4 2.45 2.20 -2.13 -2.18 -2.39; -3.87 -2.66 -3.14 -3.24 Ly6d Klrb1d F2rl1 Klrb1b Nope Tnfrsf12a Tlr1 Gprc5b Ddr1 Cd9 Tgfbr2 App Tpra40-pending Ghr Fcgr2b Ntrk2 Avpr1a Nr1i3 9.78 5.47; 4.11; 3.95 5.25 4.78 4.66; 3.95 4.42; 3.99 3.63 3.54 2.92 2.52 2.32 2.22 2.06 -2.12; -2.06 -2.25 -2.51 -2.97 -3.18 Tm4sf3 Ngfa Esm1 Tnfsf13 Il1rn Igfbp1 Blnk Dusp6 Bmp2 Ms4a4d Igfals 10.66 6.69; 6.29 5.96 5.56 4.31 4.15 2.63 2.16 -2.08 -2.55 -2.77 Rhoc --Hrb Rab3d Rab34 Arfgap3 3.64; 3.14 3.01; 3.37 3.18; 2.72 2.79 2.37 2.06 Calml4 S100a11 5.90 3.66 Copeb Dmtf1 Nfix Mafb 2.32 -2.00 -2.15 -2.37 Rex3 Cdkn2b Btg2 Okl38-pending Btg3 Myadm Psen2 Cd5l 8.86 4.45 3.09 2.65 2.35 2.24 -2.02 -3.12 Tubb2 Dnclc1 3.30 2.98; 2.85; 2.72 AV224521 gelsolin Extracellular matrix, cell adhesion BC004638 secreted acidic cysteine rich glycoprotein NM_010917 nidogen 1 BF583242 activated leukocyte cell adhesion molecule AK006809 SPARC related modular calcium binding 2 AF126834 periplakin BE381767 camello-like 2 NM_023455 camello-like 4 NM_023160 camello-like 1 NM_007899 extracellular matrix protein NM_007833 decorin Others Transport NM_007423 alpha fetoprotein BC010769 apolipoprotein A-IV NM_016900 caveolin 2 BC006732 cytochrome B561 NM_018816 apolipoprotein M M30697 ATP-binding cassette B1A BC026948 SEC14-like 4 (S. cerevisiae) BC022130 solute carrier family 26A1 NM_021022 ATP-binding cassette B11 AI593492 ATPpase VI11C NM_021370 amiloride-sensitive cation channel 5, intestinal Complement activation, Immune system NM_010740 complement component 1, q subcomponent, receptor 1 NM_007796 cytotoxic T lymphocyte-associated protein 2a NM_016704 complement component 6 BC022129 complement 8b Miscellaneous NM_023123 H19 fetal liver mRNA NM_008935 prominin 1 NM_032002 neuregulin 4 BC011152 golgi phosphoprotein 2 BM935811 Mus musculus integrin alpha 6 mRNA partial cds NM_011979 vanin 3 NM_133662 immediate early response 3 AB034693 endomucin AK004598 ALEX3 protein NM_013562 interferon-related developmental regulator 1 BC007478 WW domain binding protein 5 C76322 transgelin 2 NM_009636 AE binding protein 1 BB221402 fat specific gene 27 BC027197 sulfite oxidase NM_007792 cysteine and glycine-rich protein 2 BC020489 hypothetical protein LOC22367 BC025145 hypothetical protein MGC36851 BF580567 host cell factor C1 regulator 1 (XPO1-dependent) NM_019999 brain protein 17 BB464434 selenoprotein W, muscle 1 BC025105 hypothetical protein A530061A11 NM_010702 leukocyte cell-derived chemotaxin 2 NM_007995 ficolin A NM_016751 C-type lectin, superfamily 13 Unknown AK017241 RIKEN cDNA 5330417C22 gene BC021795 RIKEN cDNA 1810023F06 gene AK010477 RIKEN cDNA 2410012M21 gene BC026654 cDNA sequence BC018222 NM_138685 RIKEN cDNA 9230106L14 gene AK018605 RIKEN cDNA 4631408O11 gene BG297038 --NM_025703 RIKEN cDNA 3930402F23 gene AK007421 RIKEN cDNA 1300003D03 gene AW111083 Mus musculus transcribed sequence NM_138587 DNA segment, Chr 6, Wayne State University 176, expressed NM_026473 RIKEN cDNA 2310057H16 gene NM_026167 RIKEN cDNA 1200009K10 gene NM_133770 RIKEN cDNA 0610012P18 gene NM_026179 RIKEN cDNA 1300003D03 gene BG963358 RIKEN cDNA 5730445F03 gene Gsn -2.15 Sparc Nid1 Alcam Smoc2 Ppl Cml2 Cml4 Cml1 Ecm1 Dcn 5.54; 3.62 4.32; 2.68 2.77; 2.26 2.09 2.08 -2.08; -2.51; -2.10 -2.34 -3.38 -3.66 -3.92 Afp Apoa4 Cav2 Cyb561 Apom Abcb1a Sec14l4 Slc26a1 Abcb11 Atp11c Accn5 10.85; 9.62; 8.46 4.26; 2.85 3.08 2.52 2.27; 2.02 2.09 -2.03 -2.03 -2.60 -2.61 -3.08 C1qr1 Ctla2a C6 C8b 3.67 2.10 -2.57 -3.05 H19 Prom1 Nrg4 Golph2 --Vnn3 Ier3 Emcn-pending Alex3-pending Ifrd1 Wbp5 Tagln2 Aebp1 Fsp27 Suox Csrp2 LOC223672 MGC36851 Hcfc1r1 Brp17 Sepw1 A530061A11 Lect2 Fcna Clecsf13 6.69 3.84 3.17 3.06 3.00 2.96 2.65 2.37 2.35 2.35 2.32 2.16 2.10 2.02 -2.24 -2.30 -2.32 -2.40 -2.51 -2.61 -2.71 -2.92 -3.04 -3.45 -4.47 5330417C22Rik 1810023F06Rik 2410012M21Rik BC018222 9230106L14Rik 4631408O11Rik --3930402F23Rik 1300003D03Rik --D6Wsu176e 2310057H16Rik 1200009K10Rik 0610012P18Rik 1300003D03Rik 5730445F03Rik 6.31 4.88 4.41 4.35 4.33 3.99 3.79 3.66 3.35 3.34 3.15 3.04 2.65 2.62 2.60 2.50 NM_133929 BC026655 NM_133825 BC021951 AB056443 BI649826 NM_133775 BC019471 NM_028785 BC020021 AA215276 AK009207 NM_133960 BC021842 BC010592 NM_134147 RIKEN cDNA E330009J07 gene RIKEN cDNA 2310045A20 gene DNA segment, Chr 1, ERATO Doi 622, expressed RIKEN cDNA 2010003K11 gene hypothetical protein D630002G06 RIKEN cDNA 2310008N12 gene RIKEN cDNA 9230117N10 gene RIKEN cDNA 1810055G02 gene RIKEN cDNA 1200017A24 gene RIKEN cDNA 2810439F02 gene Mus musculus transcribed sequences RIKEN cDNA 2310007H09 gene RIKEN cDNA 9130231C15 gene RIKEN cDNA E430021N18 gene RIKEN cDNA 0610025L15 gene RIKEN cDNA D930010J01 gene E330009J07Rik 2310045A20Rik D1Ertd622e 2010003K11Rik D630002G06 2310008N12Rik 9230117N10Rik 1810055G02Rik 1200017A24Rik 2810439F02Rik --2310007H09Rik 9130231C15Rik E430021N18Rik 0610025L15Rik D930010J01Rik 2.48 2.44 2.43; 2.38 2.25 2.24 2.22 2.21 2.08 -2.10 -2.24 -2.30 -2.36 -2.71 -2.77 -3.19 -3.41 If genes are represented by more than one probe set on the chip, their individual log2 ratios are shown.