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From: Nonalcoholic Fatty Liver DiseaseA Challenge for Pediatricians
JAMA Pediatr. 2015;169(2):170-176. doi:10.1001/jamapediatrics.2014.2702
Figure Legend:
Risk Factors Associated With the Pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD)IL-6 indicates interleukin 6; INSIG,
insulin-induced gene; KLF-6, Krüppel-like factor; PNPLA3, patatinlike phospholipase domain–coding protein; PUFA, polyunsaturated
fatty acid; SNPs, single-nucleotide polymorphisms; and TNF, tumor necrosis factor.
Date of download: 8/1/2017
Copyright © 2015 American Medical
Association. All rights reserved.
From: Nonalcoholic Fatty Liver DiseaseA Challenge for Pediatricians
JAMA Pediatr. 2015;169(2):170-176. doi:10.1001/jamapediatrics.2014.2702
Figure Legend:
Proposed Mechanism for the Beneficial Effects of Docosahexaenoic Acid (DHA)During the development of nonalcoholic fatty liver
disease (NAFLD), G protein–coupled receptor (GPR120) expressed in liver resident cells may activate the transcription of
proinflammatory cytokines, including tumor necrosis factor (TNF) and interleukins (IL-6 and IL-1β), via phosphorylated nuclear
factor–κB (pNF-κB). Administration of DHA may inhibit this process.
Date of download: 8/1/2017
Copyright © 2015 American Medical
Association. All rights reserved.
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